28841-62-5Relevant articles and documents
INOSITOL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM
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Page 3, (2010/02/06)
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Pathway of dephosphorylation of myo-inositol hexakisphosphate by phytases of legume seeds
Greiner, Ralf,Larsson Alminger, Marie,Carlsson, Nils-gunnar,Muzquiz, Mercedes,Burbano, Carmen,Cuadrado, Carmen,Pedrosa, Mercedes M.,Goyoaga, Carmen
, p. 6865 - 6870 (2007/10/03)
Using a combination of high-performance ion chromatography analysis and kinetic studies, the pathway of dephosphorylation of myo-inositol hexakisphosphate by the phytases purified from faba bean and lupine seeds, respectively, was established. The data demonstrate that the legume seed phytases under investigation dephosphorylate myo-inositol hexakisphosphate in a stereospecific way. The phytase from faba bean seeds and the phytase LP2 from lupine seeds degrade phytate by sequential removal of phosphate groups via D-Ins(1,2,3,5,6)P5, D-Ins(1,2,5,6)P4, D-Ins(1,2,6)P3, and D-Ins(1,2)P2 to finally Ins(2)P, whereas the phytases LP11 and LP12 from lupine seeds generate the final degradation product Ins(2)P via D-Ins(1,2,4,5,6)P5, D-Ins(1,2,5,6)P4, D-Ins(1,2,6)P3, and D-Ins(1,2)P2.
Enzyme assisted synthesis of D-myo-inositol-1,2,6-trisphosphate
Andersch,Schneider
, p. 349 - 352 (2007/10/03)
The title compound is prepared in enantiomerically pure form via a facile enzyme assisted route. Essential for the success of the described method were a) the highly enantioselective esterification of 4,6-O-dibenzoyl-myo-inositol 2, b) the selective acylation of the axial hydroxyl function in 3 and c) the selective, base catalysed methanolysis of one benzoate group in 5. The obtained, selectively protected 1,2,6-triol 6 was converted into the title compound 7 by phosphorylation using N,N-dimethyl dibenzyl phosphoamidite followed by deprotection.