454199-95-2

Upstream product

• 116-11-0 2-Methoxypropene 
• 455268-36-7 L-1,2,6-tri-O-benzoyl-myo-inositol 
• 454200-06-7 L-1,6-di-O-benzoyl-3,4-O-isopropylidene-myo-inositol 
• 707-07-3 orthobenzoic acid trimethyl ester 
• 165883-87-4 L-1,6-di-O-benzoyl-myo-inositol 

Downstream Products

• 455268-44-7 D-3,4,5-tri-O-benzoyl-myo-inositol 1,2,6-tris(diethyl phosphate) 
• 455268-40-3 D-2,3,4-tri-O-benzoyl-myo-inositol 1,5,6-tris(diethyl phosphate) 
• 454198-68-6 D-2,3,5-tri-O-benzoyl-myo-inositol 1,4,6-tris(diethyl phosphate) 
• 454198-75-5 L-2,5,6-tri-O-benzoyl-myo-inositol 1,3,4-tris(diethyl phosphate) 
• 28841-62-5 D-myo-inositol 1,2,6-trisphosphate 
• 114488-20-9 myo-Inositol 1,5,6-trisphosphate 
• 93133-75-6 Inositol 1,3,4-triphosphate 
• 454198-44-8 L-1,2,5-tri-O-benzoyl-myo-inositol 
• 454198-46-0 D-2,4,5-tri-O-benzoyl-myo-inositol 
• 455268-36-7 L-1,2,6-tri-O-benzoyl-myo-inositol 
• 142630-99-7 1D-3,4,5-O-tribenzoyl-myo-inositol 

Relevant academic research and scientific papers

Divergent syntheses of all possible optically active regioisomers of myo-inositol tris- and tetrakisphosphates

Since the discovery of D-myo-inositol 1,4,5-trisphosphate, which plays a pivotal role as a second messenger in transmembrane signaling, the scope of the phosphoinositide-based signaling processes has been continually expanding. However, the clear understanding of the molecular signal transduction mechanisms including the functions of newly found IPn is still lacking. As a continuing effort to our previously reported syntheses of all possible 39 optically inactive regioisomers of myoinositol phosphates (IPn; n = 1-6), we synthesized all possible optically active regioisomers of myo-IP3 and myo-IP4 using chiral IBz3s and IBz2s, respectively. A series of procedures involving CRL-catalyzed enzymatic resolution of racemic 1,2:5,6-di-O-isopropylidene-myo-inositol and base-catalyzed benzoyl migration in tri- and dibenzoyl-isopropylidene-myo-inositol afforded eight enantiomeric pairs of IBz3 and six enantiomeric pairs of IBz2, respectively. Phosphorylation of these intermediates by the phosphitylation and oxidation procedure gave the target products.