28862-12-6

Basic information

• Product Name: 1-BENZYL-1H-1,2,3-TRIAZOLE-4-CARBOXYLIC ACID
• Synonyms: 1H-1,2,3-Triazole-4-carboxylic acid, 1-(phenylMethyl)-;1-Benzyl-4-carboxy-1H-1,2,3-triazole, alpha-(4-Carboxy-1H-1,2,3-triazol-1-yl)toluene
• CAS NO: 28862-12-6
• Molecular Formula: C₁₀H₉N₃O₂
• Molecular Weight: 203.2
• Mol File: 28862-12-6.mol
• Article Data: 41

Chemical Properties

• Boiling Point: 453.798°C at 760 mmHg
• Flash Point: 228.249°C
• Appearance: /
• Density: 1.343g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.651
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-BENZYL-1H-1,2,3-TRIAZOLE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZYL-1H-1,2,3-TRIAZOLE-4-CARBOXYLIC ACID(28862-12-6)
• EPA Substance Registry System: 1-BENZYL-1H-1,2,3-TRIAZOLE-4-CARBOXYLIC ACID(28862-12-6)

Safety Data

• Hazardous Substances Data: 28862-12-6(Hazardous Substances Data)

Usage

General Description

1-BENZYL-1H-1,2,3-TRIAZOLE-4-CARBOXYLIC ACID is a chemical compound with a molecular formula C11H9N3O2. It is a benzyl-substituted triazole derivative with a carboxylic acid functional group. 1-BENZYL-1H-1,2,3-TRIAZOLE-4-CARBOXYLIC ACID has been studied for its potential therapeutic applications, particularly in the fields of pharmaceuticals and agrochemicals. Its unique structure and properties make it a valuable building block in organic synthesis and drug discovery. Research has shown that this compound exhibits promising biological activities, making it a key target for further investigation in medicinal chemistry and related fields.

InChI:InChI=1/C10H9N3O2/c14-10(15)9-7-13(12-11-9)6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H,14,15)

Upstream product

• 126800-24-6 ethyl 1-(benzyl)-1H-1,2,3-triazole-4-carboxylate 
• 100-51-6 benzyl alcohol 
• 31875-99-7 4-bromo-1-(phenylmethyl)-1H-1,2,3-triazole 
• 74-88-4 methyl iodide 
• 600-05-5 2,3-dibromopropionic acid 
• 622-79-7 benzyl azide 
• 100-39-0 benzyl bromide 
• 1016013-16-3 C₁₈H₁₆N₄O 
• 1237511-96-4 C₁₈H₁₈N₄O 
• 1416136-96-3 N,N,N’,N’-tetramethyl-1-benzyl-1,2,3-triazole-4-carboxamidinium tetraphenylborate 
• 471-25-0 Propiolic acid 
• 922-67-8 propynoic acid methyl ester 
• 76003-76-4 1-benzyl-1H-[1,2,3]triazole-4-carboxylic acid methyl ester 

Downstream Products

• 1258502-27-0 1-benzyl-N-(2-(5-chloro-1H-indol-3-yl)ethyl)-1H-1,2,3-triazole-4-carboxamide 

Relevant articles and documents

Synthesis of new triazolyl-oxazoline chiral ligands and study of their coordination to Pd(II) metal centers

We report an improved protocol for the synthesis of TryOx, a family of N,N chiral ligands in which a 1,2,3-triazol-4-yl moiety bears a chiral 2-oxazoline as the substituent in 4 position. TryOxs were successfully employed for the preparation of cationic P

Copper(I)-chitin biopolymer based: An efficient and recyclable catalyst for click azide–alkyne cycloaddition reactions in water

The naturally occurring α-chitin biopolymer was employed for the immobilisation of copper(I) ion, resulting into a new bioconjugate complex, namely, Cu(I)-α-chitin (CuI-CHT) with catalytic efficiency in copper-catalysed azide–alkyne cycloaddition reaction

Synthesis and Characterization of Copper(I)‐Cysteine Complex Supported on Magnetic Layered Double Hydroxide as an Efficient and Recyclable Catalyst System for Click Chemistry Using Choline Azide as Reagent and Reaction Medium

Abstract: In this study, Fe3O4@LDH@cysteine–Cu(I) nanoparticles as a novel and recyclable catalytic system was designed and successfully synthesized. These nanoparticles show high catalytic activity for preparation of the triazole fa

Synthesis and biological evaluation of 1-benzyl-N-(2-(phenylamino)pyridin-3-yl)-1H-1,2,3-triazole-4-carboxamides as antimitotic agents

A library of 1-benzyl-N-(2-(phenylamino)pyridin-3-yl)-1H-1,2,3-triazole-4-carboxamides (7a–al) have been designed, synthesized and screened for their anti-proliferative activity against some selected human cancer cell lines namely DU-145, A-549, MCF-7 and HeLa. Most of them have shown promising cytotoxicity against lung cancer cell line (A549), amongst them 7f was found to be the most potent anti-proliferative congener. Furthermore, 7f exhibited comparable tubulin polymerization inhibition (IC50 value 2.04 μM) to the standard E7010 (IC50 value 2.15 μM). Moreover, flow cytometric analysis revealed that this compound induced apoptosis via cell cycle arrest at G2/M phase in A549 cells. Induction of apoptosis was further observed by examining the mitochondrial membrane potential and was also confirmed by Hoechst staining as well as Annexin V-FITC assays. Furthermore, molecular docking studies indicated that compound 7f binds to the colchicine binding site of the β-tubulin. Thus, 7f exhibits anti-proliferative properties by inhibiting the tubulin polymerization through the binding at the colchicine active site and by induction of apoptosis.