2890-60-0

Basic information

• Product Name: 1-phenylcyclohexanecarboxamide
• CAS NO: 2890-60-0
• Molecular Formula: C₁₃H₁₇NO
• Molecular Weight: 203.2802
• Mol File: 2890-60-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 387.3°C at 760 mmHg
• Flash Point: 188°C
• Density: 1.084g/cm³
• Vapor Pressure: 3.34E-06mmHg at 25°C
• Refractive Index: 1.554
• CAS DataBase Reference: 1-phenylcyclohexanecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenylcyclohexanecarboxamide(2890-60-0)
• EPA Substance Registry System: 1-phenylcyclohexanecarboxamide(2890-60-0)

Safety Data

• Hazardous Substances Data: 2890-60-0(Hazardous Substances Data)

Upstream product

• 2201-23-2 1-phenyl-1-cyclohexanecarbonitrile 
• 111-24-0 1,5-dibromo-pentane 
• 140-29-4 phenylacetonitrile 
• 1135-67-7 1-phenyl-cyclohexanecarboxylic acid 
• 2890-42-8 1-phenylcyclohexylcarbonyl chloride 

Downstream Products

• 17380-54-0 1-amino-2-phenyl-2,2-pentamethyleneethane 
• 1934-71-0 IEM 1921 
• 2201-24-3 1-phenylcyclohexylamine 
• 2201-23-2 1-phenyl-1-cyclohexanecarbonitrile 
• 17380-66-4 N-Methoxycarbonyl-1-phenyl-cyclohexylamin 

Relevant articles and documents

Synthesis and Pharmacological Properties of 1-(6-Aminohexylamino)-1-Phenylcyclohexyl Dihydrochloride (IEM-2062) as Compared with Memantine

1-(6-Aminohexylamino)-1-phenylcyclohexyl dihydrochloride (IEM-2062) had significantly greater antihypoxic, anticonvulsant, antidepressant, and analgesic activity than memantine and similar antiparkinsonism activity as memantine; it had low toxicity and was safer for use. IEM-2062 produced significant pharmacological effects in the dose range 0.3 – 3 mg/kg.

Synthesis and Anticonvulsant Activity of 1-Phenylcyclohexylamine Analogues

Thirty-eight analogues of 1-phenylcyclohexylamine (PCA), a phencyclidine (PCP) derivative, were examined for their activities in the mouse maximal electroshock (MES) seizure test and in a motor-toxicity assay.In addition, we determined the binding affinities of the compounds for PCP acceptor sites in rat brain membranes labeled with -1-piperidine.Many of the analogues were protective against MES seizures (ED50s of 4-41 mg/kg, ip) and all of these compounds caused motor toxicity.The potencies in the motor toxicity and MES seizure tests showed a moderate correlation with the affinities for PCP sites.Several analogues exhibited a greater separation of potencies in the motor toxicity and MES seizure tests than did the parent compound PCA.These were obtained by (i) 3-methylation of the cyclohexyl ring trans to the phenyl ring, (ii) methoxylation at the ortho position on the phenyl ring, and (iii) contraction of the cyclohexane ring to form the corresponding cyclopentane.