289054-47-3Relevant academic research and scientific papers
PYRAZOLYL ACYLSULFONAMIDE DERIVATIVES AS ENDOTHELIN CONVERTING ENZYME INHIBITORS AND USEFUL IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
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Page/Page column 31-32, (2008/06/13)
The invention provides compounds of formula (I),wherein R?1?,R?2? ,R?3? and R?4? are as defined in the specification,processes for preparing such compounds,to pharmaceutical compositions comprising such compounds and to the use of the compounds as active
Chemoselective synthesis of 3- and 5-pyrazolylacetates
Vicentini, Chiara B.,Manfrini, Maurizio,Mazzanti, Manuela,Manferdini, Monica,Morelli, Carlo F.,Veronese, Augusto C.
, p. 1285 - 1292 (2007/10/03)
Methyl 3,5-dioxohexanoate (1) reacts with hydrazines (2) in methanol or acetic acid to give a mixture of the isomeric pyrazolylacetates (3) and (4), whose molar ratio depends on the solvent and hydrazine. 2,2-Dimethyl-5-(1- hydroxy-3-oxobutylidene)-1,3-dioxane-4,6-dione (5) reacts chemoselectively with hydrazines to give the 5-pyrazolylacetates (3) as the only reaction products.
