28916-25-8

Upstream product

• 97-93-8 triethylaluminum 
• 100-47-0 benzonitrile 
• 75-31-0 isopropylamine 
• 132555-77-2 N-(2-bromo-3,3-dimethyl-1-phenyl-1-butylidene)isopropylamine 
• 93-55-0 1-phenyl-propan-1-one 

Downstream Products

• 116670-42-9 (3S,4R)-1-Isopropyl-4-methyl-3-phenyl-azetidin-2-one 
• 75458-37-6 cis-1-Isopropyl-2-methyl-3-phenylaziridine 
• 21120-36-5 1-fluoroethyl phenyl ketone 
• 98394-19-5 N-(2-fluoro-1-phenylpropylidene)isopropylamine 
• 116670-48-5 [2,2-Dichloro-1-phenyl-prop-(Z)-ylidene]-isopropyl-amine 
• 148564-71-0 4-methyl-1-isopropyl-5-phenyl-2,3-pyrrolinedione 

Relevant academic research and scientific papers

Direct electrophilic α-fluorination of imines: Efficient synthesis of mono-and difluoroimines

(Chemical Equation Presented) A mild and efficient procedure to synthesize α-fluoro- and α,α-difluoroimines was developed. Various N-alkylimines derived from acetophenones were successfully monofluorinated using NFSI (N-fluorobenzenesulfonimide) in a mixture of CH3CN and DMF at 0°C. Alternatively, the same procedure without DMF gave rise to difluorinated imines when performed at room temperature. The obtained α- and α,α-difluorinated imines were subsequently reduced to give the corresponding β-fluoro- and β,β-difluoroamines in good yield.

Synthesis of 3-Phenylisoquinolones by Reaction of Simple Pyrroline-2,3-diones with Benzyne. New Mechanistic Considerations

3-Phenylisoquinolones were obtained by cycloaddition of benzyne to 5-phenylpyrroline-2,3-diones.New mechanistic hypotheses for these transformations are discussed.

Silver ion induced reactions of α-haloimines

The silver ion induced reactions of α-haloimines are markedly different from similar reactions with the corresponding α-haloketones. The various reactions of α-haloimines, including α-alkoxylation 1,2-dehydrohalogenation, rearrangement via α-alkoxyaziridines, Favorskii-rearrangement and Wagner Meerwein rearrangement, are compared and evaluated with silver-induced reactions of α-haloketones The silver ion assisted reactions of α-haloimines are best interpreted in terms of the intermediacy c α-imidoylcarbenium ions or pseudo-α-imidoylcarbenium ions.

Enantiospecific and Stereospecific Rhodium(I)-Catalyzed Carbonylation and Ring Expansion of Aziridines. Asymmetric Synthesis of β-Lactams and the Kinetic Resolution of Aziridines

Rhodium(I) complexes catalyze the regiospecific ring expansion-carbonylation reaction of aziridines to β-lactams.This process is both stereospecific and enantiospecific, occuring with retention of configuration e.g., (S)-1-tert-butyl-2-phenylaziridine is