75458-37-6Relevant academic research and scientific papers
Synthesis of 1,2,3-trisubstituted and 1,2,2,3-tetrasubstituted aziridines from α-chloroketimines
De Kimpe, Norbert,Moens, Luc
, p. 2965 - 2974 (2007/10/02)
Secondary α-chloroketimines react with lithium aluminium hydride in ether to afford mixtures of cis-and trans-1,2,3-trisubstituted aziridines. The reaction products are formed by nucleophilic addition of hydride across the imino bond and subsequent intram
Enantiospecific and Stereospecific Rhodium(I)-Catalyzed Carbonylation and Ring Expansion of Aziridines. Asymmetric Synthesis of β-Lactams and the Kinetic Resolution of Aziridines
Calet, Serge,Urso, Fabio,Alper, Howard
, p. 931 - 934 (2007/10/02)
Rhodium(I) complexes catalyze the regiospecific ring expansion-carbonylation reaction of aziridines to β-lactams.This process is both stereospecific and enantiospecific, occuring with retention of configuration e.g., (S)-1-tert-butyl-2-phenylaziridine is
Stereospecific Synthesis of N-Substituted cis-2-Aryl-3-alkylaziridines
Kimpe, Norbert De,Verhe, Roland,Buyck, Laurent De,Schamp, Niceas
, p. 5319 - 5325 (2007/10/02)
A convenient stereospecific synthesis of N-substituted cis-2-aryl-3-alkylaziridines is reported, by reaction of N-alkyl or N-aryl α,α-dichloroalkyl aryl ketimines with lithium aluminum hydride in ethereal medium.The mechanism involves the addition of hydr
