2894-71-5

Basic information

• Product Name: 7-chloro 5-(2-chlorophenyl)-1,3-dihydro-2H-(1,4)-benzodiazepine-2-thione
• Synonyms: 7-chloro 5-(2-chlorophenyl)-1,3-dihydro-2H-(1,4)-benzodiazepine-2-thione;7-Chloro-1,3-dihydro-5-(o-chlorophenyl)-2H-1,4-benzodiazepin-2-thione;7-CHLORO-5-(2-CHLOROPHENYL)-2-THIONO-2,3-DIHYDRO-1H-1,4-BENZODIAZEPINE(WXG00673)
• CAS NO: 2894-71-5
• Molecular Formula: C₁₅H₁₀Cl₂N₂S
• Molecular Weight: 321.22
• Product Categories: Aromatics;Heterocycles;Sulfur & Selenium Compounds
• Mol File: 2894-71-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 251-253 °C
• Boiling Point: 437.8°C at 760 mmHg
• Flash Point: 218.6°C
• Appearance: /
• Density: 1.42g/cm³
• Vapor Pressure: 7.29E-08mmHg at 25°C
• Refractive Index: 1.695
• PKA: 9.58±0.40(Predicted)
• CAS DataBase Reference: 7-chloro 5-(2-chlorophenyl)-1,3-dihydro-2H-(1,4)-benzodiazepine-2-thione(CAS DataBase Reference)
• NIST Chemistry Reference: 7-chloro 5-(2-chlorophenyl)-1,3-dihydro-2H-(1,4)-benzodiazepine-2-thione(2894-71-5)
• EPA Substance Registry System: 7-chloro 5-(2-chlorophenyl)-1,3-dihydro-2H-(1,4)-benzodiazepine-2-thione(2894-71-5)

Safety Data

• Hazardous Substances Data: 2894-71-5(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

An intermediate in the synthesis of the metabolite of Triazolam. Controlled Substance.

InChI:InChI=1/C15H10Cl2N2S/c16-9-5-6-13-11(7-9)15(18-8-14(20)19-13)10-3-1-2-4-12(10)17/h1-7H,8H2,(H,19,20)

Upstream product

• 5504-92-7 2-(2-bromo-acetylamino)-5,2'-dichloro-benzophenone 
• 2958-36-3 (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone 
• 106-47-8 4-chloro-aniline 
• 609-65-4 o-chlorobenzoyl chloride 
• 2894-67-9 delorazepam 

Downstream Products

• 88701-66-0 2-2-(butoxycarbonyl)hydrazino>-7-chloro-5-(2-chlorophenyl)-3H-1,4-benzodiazepine 
• 57616-49-6 {3-[7-chloro-5-(2-chloro-phenyl)-3H-benzo[e][1,4]diazepin-2-ylsulfanyl]-propyl}-dimethyl-amine 
• 61807-88-3 N-<<2-<<7-chloro-5-(o-chlorophenyl)-3H-1,4-benzodiazepin-2-yl>amino>methyl>-1,3-dioxolan-2-yl>methylphthalimide 
• 67373-10-8 7-chloro-5-(2-chloro-phenyl)-2-methoxy-3H-benzo[e][1,4]diazepine 
• 57616-47-4 7-chloro-5-(2-chlorophenyl)-2-(2-dimethylaminoethylthio)-3H-1,4-benzodiazepine 
• 28546-59-0 2-(methyl-thio)-5-(o-chlorophenyl)-7-chloro-3H-1,4-benzodiazepine 
• 67974-55-4 7-Chloro-5-(2-chloro-phenyl)-2-ethylsulfanyl-3H-benzo[e][1,4]diazepine 
• 67974-56-5 7-Chloro-5-(2-chloro-phenyl)-2-propylsulfanyl-3H-benzo[e][1,4]diazepine 
• 67974-57-6 2-Butylsulfanyl-7-chloro-5-(2-chloro-phenyl)-3H-benzo[e][1,4]diazepine 
• 82874-24-6 7-Chloro-5-(2-chloro-phenyl)-2-(2-ethoxy-ethylsulfanyl)-3H-benzo[e][1,4]diazepine 
• 85683-65-4 8-Chloro-6-(2-chloro-phenyl)-1-ethylsulfanylmethyl-4H-2,3,5,10b-tetraaza-benzo[e]azulene 
• 85677-81-2 8-Chloro-6-(2-chloro-phenyl)-1-phenylsulfanylmethyl-4H-2,3,5,10b-tetraaza-benzo[e]azulene 
• 82874-25-7 Benzoic acid 2-[7-chloro-5-(2-chloro-phenyl)-3H-benzo[e][1,4]diazepin-2-ylsulfanyl]-ethyl ester 
• 49549-37-3 [7-chloro-5-(2-chloro-phenyl)-3H-benzo[e][1,4]diazepin-2-yl]-(2,2-dimethoxy-1-methyl-ethyl)-amine 

Relevant articles and documents

Pyrazolobenzodiazepines: Part I. Synthesis and SAR of a potent class of kinase inhibitors

A novel series of pyrazolobenzodiazepines 3 has been identified as potent inhibitors of cyclin-dependent kinase 2 (CDK2). Their synthesis and structure-activity relationships (SAR) are described. Representative compounds from this class reversibly inhibit CDK2 activity in vitro, and block cell cycle progression in human tumor cell lines. Further exploration has revealed that this class of compounds inhibits several kinases that play critical roles in cancer cell growth and division as well as tumor angiogenesis. Together, these properties suggest a compelling basis for their use as antitumor agents.

Synthesis and spectral properties of 2-[(o- and p-substituted)aminophenyl]-3H-5-[(o- and p-substituted)phenyl]-7-chloro-1,4-benzodiazepines

A series of twelve new 2-[(o- and p-substituted)aminophenyl]-3H-5-[(o- and p-substituted)phenyl]-7-chloro-1,4-benzodiazepines, which have possible pharmacological properties has been obtained. The synthesis was carried out following six steps. The structure of all products was corroborated by ir, 1H nmr, 13C nmr and ms. In addition for the compound 2-(o-chloroaminophenyl)-3H-5-(o-fluorophenyl)-7-chloro-1,4-benzodiazepine 7, its structure was confirmed by X-ray diffraction.

2-(2-Alkynylamino)-3H-1,4-benzodiazepines

Novel 6-substituted 4H-imidazo[1,2-a][1,4]benzodiazepines, the intermediate 5-substituted-2-(2-alkynylamino)-3H-1,4-benzodiazepines, pharmacologically acceptable acid addition salts thereof, and processes for their production. The compounds of this invention and the pharmacologically acceptable acid addition salts thereof are central nervous system depressants. They are useful as sedatives, hypnotics, tranquilizers, muscle relaxants and anticonvulsants, and also as feed additives for increasing growth rate and feed efficiency of livestock and poultry, milk production in the mammalian species and egg production in avian species.