28948-58-5

Basic information

• Product Name: 7-CHLORO-THIENO[2,3-C] PYRIDINE
• Synonyms: 7-CHLORO-THIENO[2,3-C] PYRIDINE;7-Chlorothieno[2,3-c]pyri...;Thieno[2,3-c]pyridine, 7-chloro-
• CAS NO: 28948-58-5
• Molecular Formula: C₇H₄ClNS
• Molecular Weight: 169.63
• Product Categories: API intermediates;Heterocycle-Pyridine series
• Mol File: 28948-58-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 296.5 °C at 760 mmHg
• Flash Point: 133.1 °C
• Appearance: /
• Density: 1.435
• Vapor Pressure: 0.00253mmHg at 25°C
• Refractive Index: 1.695
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.35±0.30(Predicted)
• CAS DataBase Reference: 7-CHLORO-THIENO[2,3-C] PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-CHLORO-THIENO[2,3-C] PYRIDINE(28948-58-5)
• EPA Substance Registry System: 7-CHLORO-THIENO[2,3-C] PYRIDINE(28948-58-5)

Safety Data

• Hazardous Substances Data: 28948-58-5(Hazardous Substances Data)

Usage

General Description

7-Chloro-thieno[2,3-c]pyridine is a chemical compound with the molecular formula C7H4ClNS. It is a heterocyclic compound that contains a thieno[2,3-c]pyridine ring system with a chlorine atom located at the 7th position. 7-CHLORO-THIENO[2,3-C] PYRIDINE is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals due to its diverse reactivity and biological properties. It is also known for its potential as an inhibitor of protein kinase C, making it a valuable tool in research and drug discovery efforts related to this enzyme. Additionally, 7-Chloro-thieno[2,3-c]pyridine has shown promising activity in the treatment of various diseases and disorders, making it a compound of interest in the field of medicinal chemistry.

InChI:InChI=1/C7H4ClNS/c8-7-6-5(1-3-9-7)2-4-10-6/h1-4H

Upstream product

• 28424-61-5 (2E)-3-(2-thiophenyl)-2-propenoyl chloride 
• 1124-65-8 3-(2-thienyl)-2-propenoic acid 
• 104587-43-1 thieno<2,3-c>pyridine 6-oxide hydrochloride 
• 28981-13-7 6H-Thieno[2,3-c]pyridin-7-one 
• 738544-01-9 thieno<2,3-c>pyridine 6-oxide 

Downstream Products

• 88255-40-7 7-(3,4-Dimethoxybenzyl)-thieno<2,3-c>pyridin 
• 104587-44-2 thieno<2,3-c>pyridine-7(6H)-thione 
• 1173825-66-5 C₁₅H₁₄N₂OS 
• 28981-13-7 6H-Thieno[2,3-c]pyridin-7-one 
• 1402598-77-9 N-((7-chlorothieno[2,3-c]pyridin-2-yl)(phenyl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide 
• 1078167-97-1 C₉H₇NO₂S 
• 104587-13-5 10-<(cis-2,6-dimethylmorpholin-4-yl)carbonyl>-8-phenyl-7H-thieno<2,3-a>quinolizin-7-one 
• 104604-87-7 N-(3-methoxypropyl)-7-oxo-8-phenyl-7H-thieno<2,3-a>quinolizine-10-carboxamide 
• 130888-44-7 10-<(morpholin-4-yl)carbonyl>-8-phenyl-7H-thieno<2,3-a>quinolizin-7-one 

Relevant articles and documents

BENZOTHIOPHENE SULFONAMIDES AND OTHER COMPOUNDS THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN

The present invention relates to benzothiophene sulfonamides and other compounds that interact with glucokinase regulatory protein. In addition, the present invention relates to methods of treating type 2 diabetes, and other diseases and/or conditions where glucokinase regulatory protein is involved using the compounds, or pharmaceutically acceptable salts thereof, and pharmaceutical compositions that contain the compounds, or pharmaceutically acceptable salts thereof.

Substituted sulfonic acid N-[(aminoiminomethyl)phenylalkyl]-azaheterocyclylamide compounds

The compounds of formula I exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from certain medical disorders. More specifically, they are inhibitors of the activity of Factor Xa. The present invention is directed to compounds of formula I, compositions containing compounds of formula I, and their use, which are for treating a patient suffering from, or subject to, physiological condition which can be ameliorated by the administration of an inhibitor of the activity of Factor Xa.

The Thienopyridine and Furopyridine Rings: New Pharmacophores with Potential Antipsychotic Activity

Two new arylpiperazine derivatives, the 4-(1-piperazinyl)thieno- and -furopyridine ring systems, have been synthesized and appended via tetramethylene chains to various imide rings.Target compounds from each series were found to have significant activity in the blockade of apomorphine stereotypy and apomorphine-induced climbing, the Sidman avoidance response, and the conditioned avoidance response.In addition, while potent affinity for serotonin 5-HT1 and 5-HT2 receptors was observed for both the thieno- and furopyridine derivatives,the interaction of these molecules with the dopamine D2 receptor was weak.Electrophysiological studies of the lead prototypes from each series, involving compounds 22 and 33, indicate these two molecules have distinctively different effects on dopamine neurons in areas A9 and A10.Despite the similarity these molecules share in their behavioral indices of antipsychotic acivity, it is likely that the thieno- and furopyridine rings employ different mechanisms to achieve this convergence of biological effects.