28981-13-7

Basic information

• Product Name: thieno[2,3-c]pyridin-7(6H)-one
• Synonyms: thieno[2,3-c]pyridin-7(6H)-one;6H-thieno[2,3-c]pyridin-7-one;Thieno[2,3-c]pyridin-7(6H);Thieno[2,3-C]Pyridin-7(6H)-One(WX619217)
• CAS NO: 28981-13-7
• Molecular Formula: C₇H₅NOS
• Molecular Weight: 151
• Mol File: 28981-13-7.mol
• Article Data: 9

Chemical Properties

• Melting Point: 195 °C
• Boiling Point: 406.0±45.0 °C(Predicted)
• Appearance: /
• Density: 1.355±0.06 g/cm3(Predicted)
• PKA: 12.36±0.20(Predicted)
• CAS DataBase Reference: thieno[2,3-c]pyridin-7(6H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: thieno[2,3-c]pyridin-7(6H)-one(28981-13-7)
• EPA Substance Registry System: thieno[2,3-c]pyridin-7(6H)-one(28981-13-7)

Safety Data

• Hazardous Substances Data: 28981-13-7(Hazardous Substances Data)

Usage

Uses

Thieno[2,3-c]pyridin-7(6H)-one is used in the study of direct and regioselective monofluorination of N-protected pyridone derivatives

Upstream product

• 60249-01-6 7-oxo-6,7-dihydro-thieno[2,3-c]pyridine-5-carboxylic acid 
• 60249-03-8 7-ethoxy-thieno[2,3-c]pyridine-5-carboxylic acid 
• 1195-52-4 trans-3-(3-thienyl)acrylic acid 
• 541-41-3 chloroformic acid ethyl ester 
• 1195-52-4 3-(3-thienyl)-2-propenoic acid 
• 28948-58-5 7-chlorothieno<2,3-c>pyridine 
• 60248-99-9 7-ethoxy-thieno[2,3-c]pyridine-5-carboxylic acid ethyl ester 
• 60248-97-7 7-oxo-6,7-dihydro-thieno[2,3-c]pyridine-5-carboxylic acid ethyl ester 
• 60249-10-7 2-azido-3-(2-diethoxymethyl-thiophen-3-yl)-acrylic acid ethyl ester 
• 60248-95-5 2-azido-3-(2-formyl-thiophen-3-yl)-acrylic acid ethyl ester 
• 61341-26-2 3-methylthenoyl chloride 
• 23806-24-8 3-methyl-2-thiophenecarboxylic acid 
• 108-05-4 vinyl acetate 
• 1400655-60-8 (thiophen-2-yl)formamido 2,2-dimethylpropanoate 

Downstream Products

• 656820-46-1 C₂₈H₂₅NO₆S 
• 591748-95-7 6-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6H-thieno[2,3-c]pyridin-7-one 
• 28948-58-5 7-chlorothieno<2,3-c>pyridine 
• 1472655-18-7 C₂₈H₂₅NO₆S 
• 1472655-27-8 C₂₈H₂₄INO₅S₂ 
• 1472655-26-7 C₂₈H₂₄INO₆S 
• 1472655-23-4 C₂₈H₂₄FNO₅S₂ 
• 1472655-22-3 C₂₈H₂₄FNO₆S 
• 1472655-19-8 C₂₈H₂₅NO₅S₂ 

Relevant articles and documents

Direct and Regioselective Monofluorination of N-Protected Pyridone Derivatives using N-Fluorobenzenesulfonimide (NFSI)

The direct monofluorination of N-protected pyridone derivatives has been developed using a stable electrophilic fluorinating reagent, N-fluorobenzenesulfonimide (NFSI). Interestingly, the fluorine atom is regioselectively introduced at the position opposite the carbonyl group in the pyridone substrate during the reaction. This method is applicable to a wide range of substrates and allows the regioselective late-stage monofluorination of pyridone scaffolds.

A METHOD FOR THE SITE-SPECIFIC ENZYMATIC LABELLING OF NUCLEIC ACIDS IN VITRO BY INCORPORATION OF UNNATURAL NUCLEOTIDES

Provided herein are analogs of unnatural nucleotides bearing predominantly hydrophobic nucleobase analogs that form unnatural base pairs during DNA polymerase- mediated replication of DNA or RNA polymerase-mediated transcription of RNA. In this manner, the unnatural nucleobases can be introduced in a site-specific way into oligonucleotides (single or double stranded DNA or RNA), where they can provide for site-specific cleavage, or can provide a reactive linker than can undergo functionalization with a cargo -bearing reagent by means of reaction with a primary amino group or by means of click chemistry with an alkyne group of the unnatural nucleobase linker.

Rhodium(III)-catalyzed C-H activation/annulation with vinyl esters as an acetylene equivalent

The behavior of electron-rich alkenes in rhodium-catalyzed C-H activation/annulation reactions is investigated. Vinyl acetate emerges as a convenient acetylene equivalent, facilitating the synthesis of sixteen 3,4-unsubstituted isoquinolones, as well as select heteroaryl-fused pyridones. The complementary regiochemical preferences of enol ethers versus enol esters/enamides is discussed.