28951-77-1Relevant academic research and scientific papers
Conformationally restricted analogues of trimethoprim: 2,6-diamino-8- substituted purines as potential dihydrofolate reductase inhibitors from Pneumocystis carinii and Toxoplasma gondii
Gangjee, Aleem,Vasudevan, Anil,Queener, Sherry F.
, p. 3032 - 3039 (2007/10/03)
Twenty-two 2,6-diamino-8-substituted purines (2-23) were synthesized, in which rotation around the two flexible bonds of trimethoprim (TMP), linking the pyrimidine ring to the side chain phenyl ring, was restricted by incorporation into a purine ring, in
