289637-71-4Relevant academic research and scientific papers
Design and synthesis of procollagen C-proteinase inhibitors
Turtle, Eric,Chow, Nicholas,Yang, Charles,Sosa, Sergio,Bauer, Udo,Brenner, Mitch,Solow-Cordero, David,Ho, Wen-Bin
, p. 7397 - 7401 (2013/02/22)
Non-peptidic inhibitors of procollagen C-proteinase (PCP) were designed from substrate leads. Compounds were optimized for potency and selectivity, with N-substituted aryl sulfonamide hydroxamates having the best combination of these properties. Compounds
N-substituted arylsulfonylamino hydroxamic acids useful as inhibitors of c-proteinase and for treating or preventing disorders related to unregulated collagen production
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, (2008/06/13)
The present invention relates to a novel class of organic molecules capable of inhibiting C-proteinase, and to their use to regulate, modulate and/or inhibit abnormal collagen formation as a therapeutic approach towards the treatment of fibrotic disorders
