88655-07-6Relevant academic research and scientific papers
Design and synthesis of procollagen C-proteinase inhibitors
Turtle, Eric,Chow, Nicholas,Yang, Charles,Sosa, Sergio,Bauer, Udo,Brenner, Mitch,Solow-Cordero, David,Ho, Wen-Bin
, p. 7397 - 7401 (2013/02/22)
Non-peptidic inhibitors of procollagen C-proteinase (PCP) were designed from substrate leads. Compounds were optimized for potency and selectivity, with N-substituted aryl sulfonamide hydroxamates having the best combination of these properties. Compounds
N-substituted arylsulfonylamino hydroxamic acids useful as inhibitors of c-proteinase and for treating or preventing disorders related to unregulated collagen production
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, (2008/06/13)
The present invention relates to a novel class of organic molecules capable of inhibiting C-proteinase, and to their use to regulate, modulate and/or inhibit abnormal collagen formation as a therapeutic approach towards the treatment of fibrotic disorders
Peptidomimetics of efflux pump inhibitors potentiate the activity of levofloxacin in Pseudomonas aeruginosa
Renau, Thomas E.,Leger, Roger,Yen, Rose,She, Miles W.,Flamme, Eric M.,Sangalang, Joan,Gannon, Carla L.,Chamberland, Suzanne,Lomovskaya, Olga,Lee, Ving J.
, p. 763 - 766 (2007/10/03)
Several classes of peptidomimetics of the efflux pump inhibitor D-ornithine-D-homophenylalanine-3-aminoquinoline (MC-02,595) have been prepared and evaluated for their ability to potentiate the activity of the fluoroquinolone levofloxacin in Pseudomonas a
