289656-89-9Relevant articles and documents
A Rapid Injection NMR Study of the Reaction of Organolithium Reagents with Esters, Amides, and Ketones
Plessel, Kristin N.,Jones, Amanda C.,Wherritt, Daniel J.,Maksymowicz, Rebecca M.,Poweleit, Eric T.,Reich, Hans J.
, p. 2310 - 2313 (2015/05/27)
Unexpectedly high rates of reaction between alkyllithium reagents and amides, compared to esters and ketones, were observed by Rapid Inject NMR and competition experiments. Spectroscopic investigations with 4-fluorophenyllithium (ArLi, mixture of monomer and dimer in THF) and a benzoate ester identified two reactive intermediates, a homodimer of the tetrahedral intermediate, stable below -100°C, and a mixed dimer with ArLi. Direct formation of dimers suggested that the ArLi dimer may be the reactive aggregate rather than the usually more reactive monomer. In contrast, RINMR experiments with ketones demonstrated that the ArLi monomer was the reactive species. (Chemical Equation Presented).
TREATMENT METHODS USING TRIARYL METHANE COMPOUNDS
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Page/Page column 31, (2008/06/13)
The use of novel inhibitors of potassium flux is disclosed for the treatment of inflammatory processes, such as multiple sclerosis, insulin-dependent (type I) diabetes mellitus, rheumatoid arthritis, peripheral neuritis and pulmonary hypertension. The com
