28970-92-5

Upstream product

• 7235-36-1 5-methoxy-indan-1,2-dione 2-oxime 
• 21883-13-6 4-methoxy-2-methylbenzonitrile 
• 94610-82-9 2-fluoro-4-methoxyphenyl nitrile 
• 105-34-0 methyl 2-cyanoacetate 
• 19614-12-1 2-bromo-5-methoxybenzyl bromide 
• 28970-91-4 2-(bromomethyl)-4-methoxybenzonitrile 
• 5111-70-6 5-methoxy-1-indanone 
• 436801-26-2 2-(cyanomethyl)-4-methoxybenzamide 

Downstream Products

• 1029008-64-7 6-methoxy-3-phenylisoquinolin-1-amine 
• 1028253-72-6 N-(3,4-difluorophenyl)-3-methyl-D-valyl-(4R)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-4-((9-methoxy-4-methyl-3,4-dihydro-2H-[1,4]oxazino[3,2-c]isoquinolin-6-yl)oxy)-L-prolinamide 
• 1028253-71-5 N-(3,4-difluorophenyl)-3-methyl-L-valyl-(4R)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-4-((9-methoxy-4-methyl-3,4-dihydro-2H-[1,4]oxazino[3,2-c]isoquinolin-6-yl)oxy)-L-prolinamide 
• 138883-16-6 2-(Cyano-ethylsulfanyl-methyl)-4-methoxy-benzonitrile 
• 138175-56-1 4-Amino-7-methoxy-2-phenyl-naphthalene-1,3-dicarbonitrile 
• 138175-53-8 4-Amino-7-methoxy-2-methyl-naphthalene-1,3-dicarbonitrile 

Relevant academic research and scientific papers

Regioselective Access to 3-Aryl-1-aminoisoquinolines via Nickel(I)-Catalyzed C-C and C-N Cascade Coupling Reactions from the Substituted 2-(Cyanomethyl)benzonitriles

A novel and regioselective Ni(I) catalyzed C-C and C-N cascade coupling reactions has been developed. The cascade furnishes atom-economic access to 40 3-aryl-1-aminoisoquinolines. The regioselectivity of C(sp3)-cyano group over C(sp2

Ultrasounds in melted poly(ethylene glycol) promote copper-catalyzed cyanation of aryl halides with K4[Fe(CN)6]

Melted poly(ethylene glycols) (PEGs) were used for the first time as solvent for the sonochemically promoted cyanation of aryl halides employing inexpensive and safe K4[Fe(CN)6] and a relatively low amount of Cu-based catalyst. The Mw (weight-average polymer molecular weight) of PEG proved to notably influence the substrate conversion, which is indicative of a strong dependence of the sonication efficacy on solvent properties. Gel permeation chromatography (GPC), X-ray photoelectron spectroscopy (XPS) and transmission electron microscopy (TEM) contributed to the characterization of the polymer and the elucidation of the catalytic system. Off the PEG: Melted poly(ethylene glycol)s (PEG)s were used for the first time as solvent for the sonochemical cyanation of aryl halides using K 4[Fe(CN)6] and a relatively low amount of Cu catalyst (5 %). The weight-average molecular weight of PEG was proven to exert a notable influence on conversion, and CuI proved to be the most efficient catalyst, affording good results within short reaction times with the use of aryl iodides and activated aryl bromides as substrates.

Hepatitis C Virus Inhibitors

Hepatitis C virus inhibitors having the general formula are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

Reduced Benzimidazo[2,1-a]isoquinolines. Synthesis and Cytotoxicity Studies

6-Butyl-5,6-dihydrobenzimidazo[2,1-a]isoquinoline, 3,9- and 3,10-dimethoxy, and 3,9- and 3,10-dihydroxy analogues, and their 12-methyl quaternary salts were prepared by a multistep route. Cytotoxicities against 55 human cancer cell lines were measured in the National Cancer Institute screen. The quaternary salts of the dimethoxy compounds (15b/c) were clearly the most active overall, with a mean graph midpoint (MGM) value of 2 μm.