21883-13-6

Basic information

• Product Name: 4-METHOXY-2-METHYLBENZONITRILE
• Synonyms: 4-METHOXY-2-METHYLBENZONITRILE;4-Methoxy-2-Methylbenzonitrile, 97%+;2-methyl-4-methoxy-carbonitrile
• CAS NO: 21883-13-6
• Molecular Formula: C₉H₉NO
• Molecular Weight: 147.17
• Product Categories: Aromatic Nitriles
• Mol File: 21883-13-6.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 104°C 5mm
• Flash Point: 115.3±15.6℃
• Appearance: /
• Density: 1.06±0.1 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.00532mmHg at 25°C
• Refractive Index: 1.522
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-METHOXY-2-METHYLBENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXY-2-METHYLBENZONITRILE(21883-13-6)
• EPA Substance Registry System: 4-METHOXY-2-METHYLBENZONITRILE(21883-13-6)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: 3276
• HazardClass: IRRITANT
• Hazardous Substances Data: 21883-13-6(Hazardous Substances Data)

Usage

General Description

4-Methoxy-2-methylbenzonitrile is an aromatic, organic compound characterized by the presence of a nitrile group (-CN) and a methoxy group (-OCH3) attached to its benzene ring. The introduction of these functional groups provides this chemical with unique physical and chemical properties. It's predominantly used in the field of organic synthesis and can serve as a versatile precursor in the production of various pharmaceuticals, dyes or agrochemicals. Little is known about the potential hazards of this compound to the environment or to human health, which warrants careful handling and further investigation. Its properties such as solubility, boiling or melting points, or reactivity highly depend on structural features imparted by the nitrile and methoxy groups.

InChI:InChI=1/C9H9NO/c1-7-5-9(11-2)4-3-8(7)6-10/h3-5H,1-2H3

Upstream product

• 75-05-8 acetonitrile 
• 100-84-5 1-methoxy-3-methyl-benzene 
• 67832-11-5 4-bromo-2-methylbenzonitrile 
• 124-41-4 sodium methylate 
• 1125-88-8 benzaldehyde dimethyl acetal 
• 140860-51-1 2-bromo-4-methoxy benzonitrile 
• 333-20-0 potassium thioacyanate 
• 773837-37-9 sodium cyanide 
• 74331-69-4 1-ethynyl-4-methoxy-2-methylbenzene 
• 557-21-1 zinc(II) cyanide 
• 27060-75-9 4-bromo-3-methylanisole 
• 4885-02-3 Dichloromethyl methyl ether 
• 4685-47-6 3,4-dimethylanisole 
• 557-21-1 dicyanozinc 

Downstream Products

• 28970-92-5 2-(cyanomethyl)-4-methoxybenzonitrile 
• 1028253-72-6 N-(3,4-difluorophenyl)-3-methyl-D-valyl-(4R)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-4-((9-methoxy-4-methyl-3,4-dihydro-2H-[1,4]oxazino[3,2-c]isoquinolin-6-yl)oxy)-L-prolinamide 
• 1028253-71-5 N-(3,4-difluorophenyl)-3-methyl-L-valyl-(4R)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-4-((9-methoxy-4-methyl-3,4-dihydro-2H-[1,4]oxazino[3,2-c]isoquinolin-6-yl)oxy)-L-prolinamide 
• 18871-84-6 (2-cyano-5-methoxyphenyl)acetyl chloride 
• 342816-22-2 2-(aminomethyl)-4-methoxybenzonitrile 
• 941693-87-4 Methyl 3-(4-methoxy-2-methylphenyl)-2-methyl-3-oxopropanoate 
• 55086-19-6 2-(2-cyano-5-methoxyphenyl)acetic acid 
• 28970-91-4 2-(bromomethyl)-4-methoxybenzonitrile 

Relevant articles and documents

Tandem organocatalyzed knoevenagel condensation/1,3-dipolar cycloaddition towards highly functionalized fused 1,2,3-triazoles

Facile synthesis of fused 1,2,3-triazoles by a proline-catalyzed reaction of an azido aldehyde and a nitroalkane is elaborated. The present tandem protocol proceeds via an organocatalytic Knoevenagel condensation of the azido aldehyde and nitroalkane followed by intramolecular azide-nitroalkene cycloaddition. The functionalized bicyclic triazole is obtained by elimination of HNO2 from the cycloadduct. Application of this strategy enabled us to synthesize a range of functionalised 5-7 membered ring fused triazoles. The reaction calls for mild conditions, affords high yields, and results in good regiospecificity while displaying excellent substrate scope.

Brush-shaped polymer with ordered side chain and preparation method and application thereof

The invention belongs to the technical field of preparation of functional polymer compounds, and particularly relates to a brush-shaped polymer with an ordered side chain and a preparation method and application thereof. The linear main chain provided by

Nickel-catalyzed cyanation of aryl halides and triflates using acetonitrile: Via C-CN bond cleavage assisted by 1,4-bis(trimethylsilyl)-2,3,5,6-tetramethyl-1,4-dihydropyrazine

We developed a non-toxic cyanation reaction of various aryl halides and triflates in acetonitrile using a catalyst system of [Ni(MeCN)6](BF4)2, 1,10-phenanthroline, and 1,4-bis(trimethylsilyl)-2,3,5,6-tetramethyl-1,4-dihydropyrazine (Si-Me4-DHP). Si-Me4-DHP was found to function as a reductant for generating nickel(0) species and a silylation reagent to achieve the catalytic cyanation via C-CN bond cleavage.