289727-10-2Relevant academic research and scientific papers
(+)-4-Phosphonophenylglycine (PPG) a new group III selective metabotropic glutamate receptor agonist
Gasparini, Fabrizio,Inderbitzin, Werner,Francotte, Eric,Lecis, Gabrielle,Richert, Paul,Dragic, Zorica,Kuhn, Rainer,Flor, Peter J.
, p. 1241 - 1244 (2007/10/03)
A new synthesis of (R,S)-PPG (4-phosphonophenylglycine) and the separation of the protected enantiomers leading after deprotection to (+)- and (-)-PPG are described. Pharmacological characterization at the group III metabotropic glutamate receptors hmGluR4a and hmGluR7b revealed (+)-PPG as the active enantiomer. (C) 2000 Elsevier Science Ltd. All rights reserved.
(R,S)-4-phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo
Gasparini,Bruno,Battaglia,Lukic,Leonhardt,Inderbitzin,Laurie,Sommer,Varney,Hess,Johnson,Kuhn,Urwyler,Sauer,Portet,Schmutz,Nicoletti,Flor, Peter J.
, p. 1678 - 1687 (2007/10/03)
Group III metabotropic glutamate receptors (mGluRs) are thought to modulate neurotoxicity of excitatory amino acids, via mechanisms of presynaptic inhibition, such as regulation of neurotransmitter release. Here, we describe (R,S)-4-phosphonophenylglycine
