72436-45-4

Usage

Uses

Used in Pharmaceutical Industry:
DIETHYL(4-FORMYLPHENYL)PHOSPHONATE is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique organophosphorus structure allows it to be a key component in the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, DIETHYL(4-FORMYLPHENYL)PHOSPHONATE is employed as a precursor in the production of pesticides and other crop protection agents. Its versatility in organic synthesis contributes to the creation of effective and targeted agrochemicals.
Used in Organic Synthesis:
DIETHYL(4-FORMYLPHENYL)PHOSPHONATE is used as a reagent in organic synthesis processes. Its ability to form stable intermediates and participate in various chemical reactions makes it a valuable asset in the synthesis of complex organic molecules.
Used in Research and Development:
DIETHYL(4-FORMYLPHENYL)PHOSPHONATE is also utilized in research and development settings, where it can be employed to study the properties and reactions of organophosphorus compounds. Its use in academic and industrial research helps to advance the understanding of chemical reactions and the development of new applications.

Upstream product

• 100-52-7 benzaldehyde 
• 762-04-9 phosphonic acid diethyl ester 
• 619-66-9 4-Carboxybenzaldehyde 
• 15164-44-0 p-(iodophenyl)carboxaldehyde 
• 122-52-1 triethyl phosphite 
• 104-88-1 4-chlorobenzaldehyde 
• 1244044-84-5 diethyl {4-[(cyclohexylamino)carbonyl]-phenyl}-phosphonate 
• 99405-03-5 1-iodo-4-(1,1-dimethoxymethyl)benzene 
• 10602-01-4 p-bromobenzaldehyde 1,3-dioxolane 
• 1122-91-4 4-bromo-benzaldehyde 
• 99405-05-7 4-(diethoxyphosphoryl)benzaldehyde dimethyl acetal 

Downstream Products

• 85425-46-3 {4-[(Benzhydryl-amino)-(diethoxy-phosphoryl)-methyl]-phenyl}-phosphonic acid diethyl ester 
• 1140970-19-9 4,6,10,12,16,18,22,24-octahydroxy-5,11,17,23-tetramethyl-2,8,14,20-tetrakis[4-(diethoxyphosphoryl)phenyl]pentacyclo[19.3.1.1^3,7.1^9,13.1^15,19]octacosa-1⁽²⁵⁾,3,5,7⁽²⁸⁾,9,11,13⁽²⁷⁾,15,17,19⁽²⁶⁾,21,23-dodecaene 
• 1140970-18-8 4,6,10,12,16,18,22,24-octahydroxy-2,8,14,20-tetrakis[4-(diethoxyphosphoryl)phenyl]pentacyclo[19.3.1.1^3,7.1^9,13.1^15,19]octacosa-1⁽²⁵⁾,3,5,7⁽²⁸⁾,9,11,13⁽²⁷⁾,15,17,19⁽²⁶⁾,21,23-dodecaene 
• 1401235-43-5 (Z)-diethyl (4-((2-oxo-4-thioxothiazolidin-5-ylidene)methyl)phenyl)phosphonate 
• 1029280-39-4 5-(4-phosphonate diethyl ester phenyl)dipyrromethane 
• 99404-99-6 [4-(2,2-Dimethyl-3-methylene-cyclopropyl)-phenyl]-phosphonic acid diethyl ester 
• 99405-11-5 [3-(2,2-Dimethyl-3-methylene-cyclopropyl)-phenyl]-phosphonic acid diethyl ester 
• 99405-10-4 (3-Diazomethyl-phenyl)-phosphonic acid diethyl ester 
• 99405-09-1 [4-(diethoxyphosphoryl)phenyl]diazomethane 
• 56701-47-4 1-(1-Methylethylidene)-2-phenylcyclopropane 
• 289727-03-3 benzyloxycarbonylamino-(4-phosphono-phenyl)-acetic acid 

Relevant academic research and scientific papers

Photosensitizers for H2 Evolution Based on Charged or Neutral Zn and Sn Porphyrins

We report a comparison between a series of zinc and tin porphyrins as photosensitizers for photochemical hydrogen evolution using cobaloxime complexes as molecular catalysts. Among all the chromophores tested, only the positively charged zinc porphyrin, [

C-P bond construction catalyzed by NiII immobilized on aminated Fe3O4@TiO2 yolk-shell NPs functionalized by (3-glycidyloxypropyl)trimethoxysilane (Fe3O4@TiO2 YS-GLYMO-UNNiII

NiII immobilized on aminated Fe3O4@TiO2 yolk-shell NPs functionalized by (3-glycidyloxypropyl)trimethoxysilane (Fe3O4@TiO2 YS-GLYMO-UNNiII) was prepared as a stable, h

Decarbonylative Phosphorylation of Carboxylic Acids via Redox-Neutral Palladium Catalysis

We describe the direct synthesis of organophosphorus compounds from ubiquitous aryl and vinyl carboxylic acids via decarbonylative palladium catalysis. The catalytic system shows excellent scope and tolerates a wide range of functional groups (>50 examples). The utility of this powerful methodology is highlighted in the late-stage derivatization directly exploiting the presence of the prevalent carboxylic acid functional group. DFT studies provided insight into the origin of high bond activation selectivity and P(O)-H isomerization pathway.

With the H-phosphonates fragrant aldehyde dehydrogenation coupling method of preparing formoxyl phosphine ester

The invention discloses a method for preparing formylaryl phosphonate by dehydrogenation coupling of aromatic aldehyde and H-phosphonate. The method comprises the following steps: dissolving Ag2O and K2S2O8 in a mixed solution of CH3CN/H2O, adding to a mixed solution of dialkyl phosphonate and aromatic aldehyde, and reacting under stirring for 1.5 hours at 95-105 DEG C to obtain a reactant, wherein the molar ratio of dialkyl phosphonate to aromatic aldehyde is (1.8-2.2): 1, the molar ratio of Ag2O to aromatic aldehyde is 4.5%-5.5% and the molar ratio of K2S2O8 to aromatic aldehyde is (1.8-2.2): 1; filtering the reactant to obtain a filtrate and filter residue; washing the filter residue with ethyl acetate to obtain a washing liquid; mixing the filtrate and the washing liquid, concentrating to obtain a concentrate and separating the concentrate by column chromatography to obtain formylaryl phosphonate.

A dehydrogenative cross-coupling reaction between aromatic aldehydes or ketones and dialkyl H-phosphonates for formyl or acylphenylphosphonates

A novel DCC reaction between aromatic aldehydes or ketones and H-phosphonates has been developed for the synthesis of p-formyl or p-acylphenylphosphonates. The synthetic method has excellent para regioselectivities, good yields, and broad substrate scopes and is more benign to the environment. The DCC reaction also tolerates many functional groups, and results in a series of new p-formyl and p-acylphenylphosphonates, which should be important building blocks for the synthesis of versatile arylphosphonate derivatives.

Synthesis, spectroscopic and electrochemical studies of phosphoryl and carbomethoxyphenyl substituted corroles, and their anion detection properties

The synthesis, electrochemical studies and anion detection properties of triphosphoryl (2) and triester corroles (3) are reported and compared with triphenylcorrole (1). These corroles exhibited typical acid-base binding behaviour in CH3CN and

An improved procedure for the synthesis of aryl phosphonates by palladium-catalysed cross-coupling of aryl halides and diethyl phosphite in polyethylene glycol

A general and greener protocol for the synthesis of aryl phosphonates by the cross-coupling of aryl halides and diethyl phosphite using tetrakis(triphenylphosphine)palladiume/triethylamine/polyethylene glycol 600 [Pd(PPh3)4/ Et3N/PEG 600] as an efficient catalytic system has been developed. This procedure also avoids hazardous solvents and is therefore an eco-friendly alternative to the existing methods.

Controlled and chemoselective reduction of secondary amides

This communication describes a metal-free methodology involving an efficient and controlled reduction of secondary amides to imines, aldehydes, and amines in good to excellent yields under ambient pressure and temperature. The process includes a chemoselective activation of a secondary amide with triflic anhydride in the presence of 2-fluoropyridine. The electrophilic activated amide can then be reduced to the corresponding iminium using triethylsilane, a cheap, rather inert, and commercially available reagent. Imines can be isolated after a basic workup or readily transformed to the aldehydes following an acidic workup. The amine moiety can be accessed via a sequential reductive amination by the addition of silane and Hantzsch ester hydride in a one-pot reaction. Moreover, this reduction tolerates various functional groups that are usually reactive under reductive conditions and is very selective to secondary amides.

Synthesis of calix[4]resorcinarenes with phosphorylaryl substituents at the lower rim of the molecule

Reaction of resorcinarenes with 4-phosphorylbenzaldehydes afforded calix[4]resorcinarenes, bearing phosphorylaryl substituents at the lower rim of the molecule.

Efficient charge injection from the S2 photoexcited state of special-pair mimic porphyrin assemblies anchored on a titanium-modified ITO anode

A novel surface fabrication methodology has been accomplished, aimed at efficient anodic photocurrent generation by a photoexcited porphyrin on an ITO (indium-tin oxide) electrode. The ITO electrode was submitted to a surface sol-gel process with titanium