28988-21-8 Usage
General Description
3-Bromothieno[2,3-b]pyridine is a chemical compound with the molecular formula C8H5BrNS. It is a heterocyclic compound that contains a thieno[2,3-b]pyridine core with a bromine substituent at the 3-position. 3-Bromothieno[2,3-b]pyridine is commonly used in organic synthesis and medicinal chemistry to create novel molecules with potential pharmaceutical properties. It has been studied for its potential as a therapeutic agent for various diseases, including cancer and neurological disorders. 3-Bromothieno[2,3-b]pyridine is known for its unique chemical reactivity and the ability to participate in a variety of organic reactions, making it a valuable building block in the synthesis of biologically active compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 28988-21-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,9,8 and 8 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 28988-21:
(7*2)+(6*8)+(5*9)+(4*8)+(3*8)+(2*2)+(1*1)=168
168 % 10 = 8
So 28988-21-8 is a valid CAS Registry Number.
InChI:InChI=1/C7H4BrNS/c8-6-4-10-7-5(6)2-1-3-9-7/h1-4H
28988-21-8Relevant articles and documents
Discovery of (S)-1-(1-(Imidazo[1,2- a ]pyridin-6-yl)ethyl)-6-(1-methyl-1 H -pyrazol-4-yl)-1 H -[1,2,3]triazolo[4,5- b ]pyrazine (Volitinib) as a Highly Potent and Selective Mesenchymal-Epithelial Transition Factor (c-Met) Inhibitor in Clinical Development for Treatment of Cancer
Jia, Hong,Dai, Guangxiu,Weng, Jianyang,Zhang, Zhulin,Wang, Qing,Zhou, Feng,Jiao, Longxian,Cui, Yumin,Ren, Yongxin,Fan, Shiming,Zhou, Jinghong,Qing, Weiguo,Gu, Yi,Wang, Jian,Sai, Yang,Su, Weiguo
supporting information, p. 7577 - 7589 (2014/12/11)
HGF/c-Met signaling has been implicated in human cancers. Herein we describe the invention of a series of novel triazolopyrazine c-Met inhibitors. The structure-activity relationship of these compounds was investigated, leading to the identification of compound 28, which demonstrated favorable pharmacokinetic properties in mice and good antitumor activities in the human glioma xenograft model in athymic nude mice.
CERTAIN TRIAZOLOPYRIDINES AND TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR
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Page/Page column 33, (2011/07/30)
Provided are certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use therefor.
