272-23-1

Usage

Uses

Used in Pharmaceutical Industry:
Thieno[2,3-b]pyridine (8CI,9CI) is used as a key intermediate in the synthesis of new drugs for the treatment of various diseases and disorders. Its unique structure allows for the development of compounds with novel therapeutic properties, offering potential benefits in areas such as cardiovascular, neurological, and oncological treatments.
Used in Agrochemical Industry:
In the agrochemical sector, Thieno[2,3-b]pyridine (8CI,9CI) is utilized in the production of pesticides and herbicides. Its incorporation into these products can enhance their effectiveness in controlling pests and weeds, thereby improving crop yields and food security.
Used in Organic Electronics and Materials Science:
Thieno[2,3-b]pyridine (8CI,9CI) has demonstrated promise in the field of organic electronics, where it can be used to develop new materials with improved electronic properties. Its application in materials science also extends to the creation of advanced organic materials with potential uses in various industries, such as energy storage, sensors, and optoelectronics.
However, it is crucial to handle Thieno[2,3-b]pyridine with care due to its potential health and environmental hazards. Proper safety measures and disposal methods should be implemented to minimize any adverse effects associated with its use.

InChI:InChI=1/C7H5NS/c1-2-6-3-5-9-7(6)8-4-1/h1-5H

Upstream product

• 56-81-5 glycerol 
• 52505-46-1 ethyl 3-aminothieno[2,3-b]pyridine-2-carboxylate 
• 53174-99-5 thieno[2,3-b]pyridine-3-carbaldehyde 
• 609-40-5 2-nitrothiophene 
• 102-52-3 malonaldehydebis(dimethylacetal) 
• 122-31-6 malondialdehyde bis(diethyl acetal) 
• 59944-78-4 ethyl thieno[2,3-b]pyridine-2-carboxylate 
• 109216-74-2 1-oxo-2,3-dihydrothieno<2,3-b>pyridine 
• 103020-26-4 3-(3-butylnylthio)-1,2,4-triazine 
• 99429-79-5 2-ethoxycarbonyl-N-(3-t-butyloxycarbonyl-2-thienyl)acetamide 
• 99429-66-0 2-ethoxycarbonyl-N-(3-ethoxycarbonyl-2-thienyl)acetamide 
• 99429-68-2 5-ethoxycarbonyl-4-hydroxythieno<2,3-b>pyridin-6(7H)-one 
• 99429-78-4 4-hydroxythieno<2,3-b>pyridin-6(7H)-one 
• 59739-05-8 tert-butyl 2-aminothiophene-3-carboxylate 

Downstream Products

• 18354-53-5 2-ethylthieno[2,3-b]pyridine 
• 72808-92-5 2-bromothieno[2,3-b]pyridine 
• 478148-97-9 thieno[2,3-b]pyridine-6-carboxylic acid 
• 41449-28-9 2-Amino-thieno<2,3-b>pyridin 
• 53399-38-5 thieno[2,3-b]pyridine-3-carbonitrile 
• 37049-39-1 Thieno<2,3-b>pyridin-1,1-dioxid 
• 53399-37-4 3-Jodthieno<2,3-b>pyridin 
• 28988-21-8 3-bromanylthieno[2,3-b]pyridine 
• 53399-36-3 3-Chlorthieno<2,3-b>pyridin 
• 53174-98-4 2-formylthieno<2,3-b>pyridine 

Relevant academic research and scientific papers

Five-membered heterocyclic oxo carboxylic acid compound and medical application thereof

The invention relates to a five-membered heterocyclic oxo carboxylic acid compound and a medical application thereof. Specifically, the invention relates to a compound, a pharmaceutical salt, a prodrug, a hydrate, a solvate or a crystal form as shown in a formula (I), and also relates to a preparation method of the compound, a pharmaceutical composition containing the compound and an application of the pharmaceutical composition as a secretion regulator of interferon type I, especially as an STING agonist in preparation of medicines for preventing and/or treating I-type interferon related diseases.

Palladium-metalated porous organic polymers as recyclable catalysts for chemoselective decarbonylation of aldehydes

A novel palladium nanoparticle (NP)-metalated porous organic ligand (Pd NPs/POL-xantphos) has been prepared for the chemoselective decarbonylation of aldehydes. This heterogenous catalyst not only has excellent catalytic activity and chemoselectivity, but also holds high activity after 10 runs of reuse. The effective usage of this method is demonstrated through the synthesis of biofuels such as furfuryl alcohol (FFA) via the highly chemoselective decarbonylation of biomass-derived 5-hydroxy-methylfurfural (HMF) with a TON up to 1540. More importantly, 9-fluorenone could be obtained in one step through the decarbonylation of 2-bromobenzaldehyde by using this heterogeneous catalyst.

Metal free coupling of heteroaryl N-tosylhydrazones and thiols: Efficient synthesis of sulfides

A metal free coupling of heteroaromatic N-tosylhydrazones with thiols is presented. A convenient synthetic route to synthesize heteroaryl N-tosylhydrazones is also showed. Valuable thioethers with pyrroles, pyridines, thieno[2,3-b]pyridines, imidazo[1,2-a]pyridines, and 6H-thieno[2,3-b]pyrroles derivatives were synthesized in good yields. This coupling reaction can be carried out in a one-pot fashion and scaled up to the gram scale by using heteroaryl aldehydes, without the need to isolate the N-tosylhydrazone.

Discovery of (S)-1-(1-(Imidazo[1,2- a ]pyridin-6-yl)ethyl)-6-(1-methyl-1 H -pyrazol-4-yl)-1 H -[1,2,3]triazolo[4,5- b ]pyrazine (Volitinib) as a Highly Potent and Selective Mesenchymal-Epithelial Transition Factor (c-Met) Inhibitor in Clinical Development for Treatment of Cancer

HGF/c-Met signaling has been implicated in human cancers. Herein we describe the invention of a series of novel triazolopyrazine c-Met inhibitors. The structure-activity relationship of these compounds was investigated, leading to the identification of compound 28, which demonstrated favorable pharmacokinetic properties in mice and good antitumor activities in the human glioma xenograft model in athymic nude mice.

CERTAIN TRIAZOLOPYRIDINES AND TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR

Provided are certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use therefor.

CERTAIN TRIAZOLOPYRIDINES AND TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR

Provided are certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use therefor.

Quinuclidines-substituted-multi-cyclic-heteroaryls for the treatment of disease

The invention provides compounds of Formula I: 1where in W is 2These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The compounds of Formula I are useful to treat diseases or conditions in which α7 is known to be involved.

Cascade radical reactions in synthesis: A new and general approach to condensed thiophenes

A novel cascade radical sequence is described for the direct conversion of ketenedithioacetals into condensed thiophenes. A noteworthy feature of this approach is its generality with respect to substituents.

Thienopyridine derivatives and their pharmaceutical use

Thienopyridine derivatives of the formula (I): STR1 wherein the ring A is an optionally substituted benzene ring; the ring B is an optionally substituted thiophene ring: X is a group of the formula: STR2 (wherein R1 is hydrogen, alkyl or alkoxy

Intramolecular Diels-Alder Reactions of 1,2,4-Triazines. A Facile Synthesis of Thienopyridines and 3,4-Dihydro-2H-thiopyranopyridines

Thienepyridines and 3,4-dihydro-2H-thiopyranopyridines have been prepared in high overall yields via intramolecular Diels-Alder reactions of properly substituted 1,2,4-triazine derivatives.A one-pot synthesis of 2,3-dihydrothienopyrid