272-23-1

Basic information

• Product Name: Thieno[2,3-b]pyridine (8CI,9CI)
• Synonyms: Thieno[2,3-b]pyridine (8CI,9CI);NSC 152397
• CAS NO: 272-23-1
• Molecular Formula: C₇H₅NS
• Molecular Weight: 135.1863
• Product Categories: THIENOPYRIDINE;Building Blocks;Thieno[x,x-y]pyridine
• Mol File: 272-23-1.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 236.5 °C at 760 mmHg
• Flash Point: 100.2 °C
• Appearance: /
• Density: 1.272 g/cm³
• Vapor Pressure: 0.0725mmHg at 25°C
• Refractive Index: 1.689
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 4.54±0.30(Predicted)
• CAS DataBase Reference: Thieno[2,3-b]pyridine (8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Thieno[2,3-b]pyridine (8CI,9CI)(272-23-1)
• EPA Substance Registry System: Thieno[2,3-b]pyridine (8CI,9CI)(272-23-1)

Safety Data

• Hazardous Substances Data: 272-23-1(Hazardous Substances Data)

Usage

General Description

Thieno[2,3-b]pyridine (8CI,9CI) is a heterocyclic compound made up of a thiophene ring fused to a pyridine ring. It is commonly used in the synthesis of pharmaceuticals, agrochemicals, and organic materials. Thieno[2,3-b]pyridine has potential applications in the development of new drugs, particularly in the treatment of various diseases and disorders. It is also utilized in the production of pesticides and herbicides for agricultural purposes. Additionally, the compound has shown promise in organic electronics and materials science, making it a versatile and valuable chemical in various industries. However, it is important to handle Thieno[2,3-b]pyridine with care due to its potential health and environmental hazards.

InChI:InChI=1/C7H5NS/c1-2-6-3-5-9-7(6)8-4-1/h1-5H

Upstream product

• 53174-99-5 thieno[2,3-b]pyridine-3-carbaldehyde 
• 609-40-5 2-nitrothiophene 
• 102-52-3 malonaldehydebis(dimethylacetal) 
• 122-31-6 malondialdehyde bis(diethyl acetal) 
• 52505-46-1 ethyl 3-aminothieno[2,3-b]pyridine-2-carboxylate 
• 59944-78-4 ethyl thieno[2,3-b]pyridine-2-carboxylate 
• 109216-74-2 1-oxo-2,3-dihydrothieno<2,3-b>pyridine 
• 103020-26-4 3-(3-butylnylthio)-1,2,4-triazine 
• 99429-79-5 2-ethoxycarbonyl-N-(3-t-butyloxycarbonyl-2-thienyl)acetamide 
• 99429-66-0 2-ethoxycarbonyl-N-(3-ethoxycarbonyl-2-thienyl)acetamide 
• 99429-68-2 5-ethoxycarbonyl-4-hydroxythieno<2,3-b>pyridin-6(7H)-one 
• 99429-78-4 4-hydroxythieno<2,3-b>pyridin-6(7H)-one 
• 59739-05-8 tert-butyl 2-aminothiophene-3-carboxylate 
• 56-81-5 glycerol 

Downstream Products

• 53399-38-5 thieno[2,3-b]pyridine-3-carbonitrile 
• 18354-53-5 2-ethylthieno[2,3-b]pyridine 
• 478148-97-9 thieno[2,3-b]pyridine-6-carboxylic acid 
• 72808-92-5 2-bromothieno[2,3-b]pyridine 
• 41449-28-9 2-Amino-thieno<2,3-b>pyridin 
• 37049-39-1 Thieno<2,3-b>pyridin-1,1-dioxid 
• 53399-37-4 3-Jodthieno<2,3-b>pyridin 
• 28988-21-8 3-bromanylthieno[2,3-b]pyridine 
• 53399-36-3 3-Chlorthieno<2,3-b>pyridin 
• 53174-98-4 2-formylthieno<2,3-b>pyridine 

Relevant articles and documents

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Palladium-metalated porous organic polymers as recyclable catalysts for chemoselective decarbonylation of aldehydes

A novel palladium nanoparticle (NP)-metalated porous organic ligand (Pd NPs/POL-xantphos) has been prepared for the chemoselective decarbonylation of aldehydes. This heterogenous catalyst not only has excellent catalytic activity and chemoselectivity, but also holds high activity after 10 runs of reuse. The effective usage of this method is demonstrated through the synthesis of biofuels such as furfuryl alcohol (FFA) via the highly chemoselective decarbonylation of biomass-derived 5-hydroxy-methylfurfural (HMF) with a TON up to 1540. More importantly, 9-fluorenone could be obtained in one step through the decarbonylation of 2-bromobenzaldehyde by using this heterogeneous catalyst.

Discovery of (S)-1-(1-(Imidazo[1,2- a ]pyridin-6-yl)ethyl)-6-(1-methyl-1 H -pyrazol-4-yl)-1 H -[1,2,3]triazolo[4,5- b ]pyrazine (Volitinib) as a Highly Potent and Selective Mesenchymal-Epithelial Transition Factor (c-Met) Inhibitor in Clinical Development for Treatment of Cancer

HGF/c-Met signaling has been implicated in human cancers. Herein we describe the invention of a series of novel triazolopyrazine c-Met inhibitors. The structure-activity relationship of these compounds was investigated, leading to the identification of compound 28, which demonstrated favorable pharmacokinetic properties in mice and good antitumor activities in the human glioma xenograft model in athymic nude mice.