289903-64-6

Upstream product

• 771-61-9 2,3,4,5,6-pentafluorophenol 
• 306-08-1 Homovanillic acid 
• 25952-53-8 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride 

Downstream Products

• 478400-46-3 N-[3-(cyclohexen-1-yl)phenyl]-4-hydroxy-3-methoxyphenylacetamide 
• 478403-00-8 4-hydroxy-N-(3-iodophenyl)-3-methoxyphenylacetamide 
• 289903-46-4 N-[2-(3,4-dimethylbenzyl)-3-(pivaloyloxy)propyl]-2-[4-(2-azidoethoxy)-3-methoxyphenyl]acetamide 
• 289903-48-6 N-[2-(4-tert-butylbenzyl)-3-(pivaloyloxy)propyl]-2-[4-(2-azidoethoxy)-3-methoxyphenyl]acetamide 
• 289903-44-2 N-[2-(4-tert-butylbenzyl)-3-(pivaloyloxy)propyl]-2-[4-(2-bromoethoxy)-3-methoxyphenyl]acetamide 
• 289903-42-0 N-[2-(3,4-dimethylbenzyl)-3-(pivaloyloxy)propyl]-2-[4-(2-bromoethoxy)-3-methoxyphenyl]acetamide 
• 289903-41-9 N-[3-pivaloyloxy-2-(4-t-butylbenzyl)propyl]-2-(4-hydroxy-3-methoxyphenyl)acetamide 
• 289903-39-5 LJO-198 

Relevant academic research and scientific papers

N-ARYLPHENYLACETAMIDE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME

N-Arylphenylacetamide derivatives represented by the following formula [I]: (wherein R1 is C1-6 alkoxy, etc.; R2 is hydrogen, -(CH2)m-N(R6)(R7) (m is an integer of from 1 to 4; R

Phenolic modification as an approach to improve the pharmacology of the 3-acyloxy-2-benzylpropyl homovanillic amides and thioureas, a promising class of vanilloid receptor agonists and analgesics

In order to improve the analgesic activity and pharmacokinetics of thioureas 2 and 3, which we previously developed as potent vanilloid receptor (VR) agonists, we prepared and characterized phenolic modifications of them and of their amide surro-gates (7, 8). The aminoethyl analogue of the amide template 13 was a potent analgesic with an EC50 =0.96 μg/kg in the AA-induced writhing test and with better in vivo stability than the parent phenol. Copyright