289914-76-7Relevant academic research and scientific papers
Exotic amino acids: I. Synthesis of α-amino acids with a cyclohexene substituent
Zitsane,Ravinya,Riikure,Tetere,Gudrinietse,Kalei
, p. 1457 - 1460 (2007/10/03)
Ylidene derivatives of Meldrum's acid reacted with isoprene in boiling chloroform to give Diels-Alder adducts. Reactions of the latter with amines were accompanied by cleavage of the 1,3-dioxane ring with formation of the corresponding amides. Hofmann rearrangement of the amides led to α-amino acid hydrochlorides which were acylated (without isolation) with di-tert-butyl dicarbonate to obtain N-tert-butoxy-carbonyl derivatives of α-amino acids of the cyclohexene series.
