289914-82-5

Upstream product

• 78-79-5 isoprene 
• 15795-62-7 2,2-dimethyl-5-(4-nitrobenzylidene)-1,3-dioxane-4,6-dione 
• 289914-76-7 3,3,9-trimethyl-11-(4-nitro-phenyl)-2,4-dioxa-spiro[5.5]undec-8-ene-1,5-dione 

Relevant academic research and scientific papers

Reaction of spirocyclic isopropylidene malonates with urea and N,N′-disubstituted ureas

Unsubstituted and N-substituted amides of 2-aryl-4-methyl-4-cyclohexene-1-carboxylic acids are formed during the fusion of 2′-aryl-2,2,4′-trimethyl-1,3-dioxan-5-spirocyclohex-4 ′-ene-4,6-diones with urea and N,N′-disubstituted ureas.

Exotic amino acids: I. Synthesis of α-amino acids with a cyclohexene substituent

Ylidene derivatives of Meldrum's acid reacted with isoprene in boiling chloroform to give Diels-Alder adducts. Reactions of the latter with amines were accompanied by cleavage of the 1,3-dioxane ring with formation of the corresponding amides. Hofmann rearrangement of the amides led to α-amino acid hydrochlorides which were acylated (without isolation) with di-tert-butyl dicarbonate to obtain N-tert-butoxy-carbonyl derivatives of α-amino acids of the cyclohexene series.