29023-48-1 Usage
Uses
Used in Pharmaceutical Industry:
1-(tert-butylamino)-3-[[4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy]propan-2-ol is used as an active pharmaceutical ingredient for the development of various medications. Its unique chemical structure allows it to interact with specific biological targets, making it a promising candidate for the treatment of different medical conditions.
Used in Cardiovascular Applications:
In the pharmaceutical industry, 1-(tert-butylamino)-3-[[4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy]propan-2-ol is used as an antihypertensive agent to help lower blood pressure and reduce the risk of cardiovascular diseases. Its ability to regulate blood pressure makes it a valuable component in the development of antihypertensive medications.
Used in Cardiac Applications:
1-(tert-butylamino)-3-[[4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy]propan-2-ol is also used as an antiarrhythmic agent, particularly in the class II category, to help regulate abnormal heart rhythms and maintain a normal heartbeat. Its potential use in treating arrhythmias contributes to its importance in the development of cardiac medications.
Used in Angina Treatment:
1-(tert-butylamino)-3-[[4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy]propan-2-ol is used as an antianginal agent to help alleviate the symptoms of angina, a condition characterized by chest pain due to insufficient blood flow to the heart. Its role in improving blood flow and reducing chest pain makes it a valuable component in the treatment of angina.
Used in Ophthalmology:
In the field of ophthalmology, 1-(tert-butylamino)-3-[[4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy]propan-2-ol is used as an antiglaucoma agent to help reduce intraocular pressure and prevent optic nerve damage in patients with glaucoma. Its ability to manage intraocular pressure makes it a crucial component in the development of glaucoma treatments.
Used in Hemangioma and Vascular Anomaly Treatment:
1-(tert-butylamino)-3-[[4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy]propan-2-ol can be used to treat hemangioma and vascular anomalies due to its potential effects on blood vessels and its ability to regulate blood flow. Its application in this area highlights its versatility in addressing various medical conditions.
Chemical Properties:
1-(tert-butylamino)-3-[[4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy]propan-2-ol is a white solid, which indicates its stability and suitability for use in various pharmaceutical formulations. Its solid-state properties contribute to its ease of handling and processing in the development of medications.
Check Digit Verification of cas no
The CAS Registry Mumber 29023-48-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,9,0,2 and 3 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 29023-48:
(7*2)+(6*9)+(5*0)+(4*2)+(3*3)+(2*4)+(1*8)=101
101 % 10 = 1
So 29023-48-1 is a valid CAS Registry Number.
InChI:InChI=1/C13H24N4O3S.C4H4O4/c1-13(2,3)14-8-10(18)9-20-12-11(15-21-16-12)17-4-6-19-7-5-17;5-3(6)1-2-4(7)8/h10,14,18H,4-9H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/i8D2,9D2,10D;
29023-48-1Relevant academic research and scientific papers
PROCESSES FOR THE PREPARATION OF 3,4-SUBSTITUTED-1,2,5-THIADIAZOLES AND INTERMEDIATES THEREOF
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Page/Page column 9, (2009/07/03)
The present invention relates to intermediate compounds useful for the preparation of 1,2,5-thiadiazole compounds, including unsymmetrically substituted compounds such as 4-(3-secondary amino-2-hydroxy-propoxy)-1,2,5-thiadiazole compounds and azacyclic or azabicyclic 1,2,5-thiadiazole compounds and to processes for making the same.
(Acyloxy)alkyl Carbamates as Novel Bioreversible Prodrugs for Amines: Increased Permeation through Biological Membranes
Alexander, Jose,Cargill, Robyn,Michelson, Stuart R.,Schwam, Harvey
, p. 318 - 322 (2007/10/02)
(Acyloxy)alkyl carbamates of the type R1R2N-CO-O-CHR3-OCO-R4 are described as novel bioreversible prodrugs for primary and secondary amines.These were prepared either by a one-step reaction involving nucleophilic attack on p-nitrophenyl α-(acyloxy)alkyl carbonates with displacement of p-nitrophenol or by reaction of α-haloalkyl carbamates with silver or mercury salts of carboxylic acids.Enzymatic hydrolysis of the ester bond in these ester carbamates leads to a cascade reaction resulting in rapid regeneration of the parent amine.Permeability measurements of such nonionic derivatives of atenolol, betaxolol, pindolol, propranolol, and timolol through fuzzy rat skin and rabbit cornea mounted on diffusion cells show that derivatization of the hydrophilic β-blockers results in several-fold increase in permeation through these biological membranes.However, prodrug modification of the lipophilic β-blockers leads to little advantage in permeability characteristics.
Novel methods and compounds employed therein
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, (2008/06/13)
Preparation of an optically active alkamine in the sinister configuration, or a derivative of said alkamine, which is reacted with an 3-X-4-chloro(or RO-- where R is hydrogen or an alkali metal)-1,2,5-thiadiazole to prepare S-3-X-4-(3-substituted amino-2-hydroxypropoxy)-1,2,5-thiadiazole beta adrenergic blocking agents. Novel 3-morpholino-4-chloro(or RO--)-1,2,5-thiadiazoles and their preparation also are described.
