22741-52-2

Basic information

• Product Name: 3-(tert-butylamino)propane-1,2-diol
• Synonyms: 3-(tert-butylamino)propane-1,2-diol;3-[(1,1-Dimethylethyl)amino]-1,2-propanediol
• CAS NO: 22741-52-2
• Molecular Formula: C₇H₁₇NO₂
• Molecular Weight: 147.21538
• EINECS: 245-190-8
• Mol File: 22741-52-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 262.4 °C at 760 mmHg
• Flash Point: 109.1 °C
• Appearance: /
• Density: 0.992 g/cm³
• Vapor Pressure: 0.00155mmHg at 25°C
• Refractive Index: 1.465
• CAS DataBase Reference: 3-(tert-butylamino)propane-1,2-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(tert-butylamino)propane-1,2-diol(22741-52-2)
• EPA Substance Registry System: 3-(tert-butylamino)propane-1,2-diol(22741-52-2)

Safety Data

• Hazardous Substances Data: 22741-52-2(Hazardous Substances Data)

Usage

General Description

3-(tert-butylamino)propane-1,2-diol is a chemical compound with the molecular formula C8H19NO2. It is a tertiary amine with a hydroxyl group on the second carbon of the propane chain. 3-(tert-butylamino)propane-1,2-diol is commonly used as a chiral auxiliary in organic synthesis to control the stereochemistry of reactions. It can also be used as a resolving agent for enantiomeric mixtures. Additionally, 3-(tert-butylamino)propane-1,2-diol has been studied for its potential as a drug delivery agent due to its ability to form stable complexes with a variety of drugs. Overall, this compound has applications in the pharmaceutical industry and organic synthesis.

InChI:InChI=1/C7H17NO2/c1-7(2,3)8-4-6(10)5-9/h6,8-10H,4-5H2,1-3H3

Upstream product

• 6387-89-9 glycidyl acetate 
• 75-64-9 tert-butylamine 
• 556-52-5 oxiranyl-methanol 
• 74924-01-9 (DL)-2,2-dimethyl-4-((tert-butylamino)methyl)-1,3-dioxolane 
• 4042-36-8 D-pyrrolidone-5-carboxylic acid 
• 98-79-3 L-Pyroglutamic acid 

Downstream Products

• 83231-29-2 4-Hydroxy-benzoic acid 3-tert-butylamino-2-hydroxy-propyl ester 
• 90531-58-1 2-Methyl-4-nitro-benzoic acid 3-tert-butylamino-2-hydroxy-propyl ester 
• 83231-22-5 3-Amino-benzoic acid 3-tert-butylamino-2-hydroxy-propyl ester 
• 90531-55-8 4-Propoxy-benzoic acid 3-tert-butylamino-2-hydroxy-propyl ester 
• 83231-12-3 4-Allyloxy-benzoic acid 3-tert-butylamino-2-hydroxy-propyl ester 
• 83231-11-2 3-Benzyloxy-benzoic acid 3-tert-butylamino-2-hydroxy-propyl ester 
• 90531-59-2 4-Amino-2-methyl-benzoic acid 3-tert-butylamino-2-hydroxy-propyl ester 
• 83231-06-5 2-Methyl-benzoic acid 3-tert-butylamino-2-hydroxy-propyl ester 
• 90531-68-3 4-Phenyl-butyric acid 3-tert-butylamino-2-hydroxy-propyl ester 
• 90531-66-1 Phenyl-acetic acid 3-tert-butylamino-2-hydroxy-propyl ester 
• 29023-48-1 timolol 
• 30315-49-2 3-tert-butyl-2-phenyl-5-hydroxymethyloxazolidine 
• 85665-60-7 (R,S)-5-(hydroxymethyl)-3-tert-butyloxazolidin-2-one 
• 83231-25-8 2-Hydroxy-benzoic acid 3-tert-butylamino-2-hydroxy-propyl ester 

Relevant articles and documents

Asymmetric hydrolysis of (R, S)-5-acetoxymethyl-3-tert-butyl- oxazolidin-2-one with enzymes and microorganisms

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propanolamines. 1. Novel β-Blockers with Ultrashort Duration of Action

Novel propanolamines were synthesized and investigated as potential ultrashort-acting β-adrenergic receptor blockers.Many of these analogues exhibited good potency and short duration.The N-ureidoalkyl analogue 85 (ACC-9089) has a potency equal to propranolol and a duration of action of about 21 min in the dog.It has been selected as a candidate for further clinical study.Structure-activity relationships and structure-duration relationships for these new β-blockers are also discussed.

Synthesis and β-Adrenergic Blocking Activity of New Aliphatic Oxime Ethers

New β-adrenergic blocking agents, most of which do not contain an aromatic nucleus, were synthesized.They were derived either from alkylamino-aliphatic oxime ethers, or alkylamino-aliphatic ethers.Most active among these are O-acetoxime (8; trachea pA2=7.65) and 1-isobutoxy-3-(tert-butylamino)-2-propanol (15, trachea pA2=7.49), both of which displayed bronchoselectivity (β2/β1 ratio ca. 15).The role and importance of the aromatic nucleus in this class of compounds are discussed