290293-82-2Relevant academic research and scientific papers
New pseudopterosin and seco-pseudopterosin diterpene glycosides from two Colombian isolates of Pseudopterogorgia elisabethae and their diverse biological activities
Rodriguez, Ileana I.,Shi, Yan-Ping,Garcia, Oscar J.,Rodriguez, Abimael D.,Mayer, Alejandro M. S.,Sanchez, Juan A.,Ortega-Barria, Eduardo,Gonzalez, Jose
, p. 1672 - 1680 (2004)
As part of an ongoing program to explore the chemical constituents of Caribbean marine invertebrates, a family of 13 new diterpene glycosides, pseudopterosins P-Z (1-11) and seco-pseudopterosins H (12) and I (13), have been isolated from the organic extra
Pseudopterosins P-V, new compounds from the gorgonian octocoral Pseudopterogorgia elisabethae from Providencia island, Colombian Caribbean
Duque, Carmenza,Puyana, Mónica,Narváez, Ginna,Osorno, Oscar,Hara, Noriyuki,Fujimoto, Yoshinori
, p. 10627 - 10635 (2004)
Seven new diterpene glycosides, pseudopterosins P (1), Q (2), R (3), S (4), T (5), U (6) and V (7) along with two known compounds PsG and PsK have been isolated from the methanol/dichloromethane extract of the gorgonian octocoral Pseudopterogorgia elisabethae collected off Providencia Island, Colombian Caribbean. The structures of the new metabolites, including their relative and absolute configuration, were established by MS and NMR spectroscopic studies as well as their conversion to known compounds. Seven new diterpene glycosides, pseudopterosins P (1), Q (2), R (3), S (4), T (5), U (6) and V (7) have been isolated from the gorgonian octocoral Pseudopterogorgia elisabethae collected off Providencia Island, Colombian Caribbean.
A direct and efficient stereocontrolled synthetic route to the pseudopterosins, potent marine antiinflammatory agents
Corey,Lazerwith, Scott E.
, p. 12777 - 12782 (2007/10/03)
Described herein is a new synthetic route to pseudopterosin aglycone (3), a key intermediate for the synthesis of a group of antiinflammatory natural products including pseudopterosin A (1) and E (2). The pathway of synthesis starts with the abundant and inexpensive (S)-(-)-limonene and its long-known cyclic hydroboration product (4) and leads to the chiral hydroxy ketone 6. Conversion of 6 to 10 followed by a novel aromatic annulation produced 15 which underwent a highly diastereoselective cyclization to afford the protected pseudopterosin aglycone 16. The naturally occurring pseudopterosins such as 1 and 2 are readily available from this key intermediate.
