290304-07-3

Upstream product

• 290303-52-5 4-[(3-chloro-4-fluoro-phenyl)amino]-7-cyclopropylmethoxy-6-nitro-quinazoline 
• 60-29-7 diethyl ether 
• 7439-89-6 iron 

Downstream Products

• 365532-31-6 4-[(3-Chloro-4-fluoro-phenyl)amino]-6-{[2-(diethoxyphosphoryl)-1-oxo-ethyl]amino}-7-cyclopropylmethoxy-quinazoline 

Relevant academic research and scientific papers

4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases

The present invention relates to bicyclic heterocycles of general formula wherein Ra to Rd, A to G and X are defined as in claim 1, the tautomers, the steroisomers and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, particularly an inhibiting effect on signal transduction mediated by tyrosine kinases, their use for treating diseases, particularly tumoral diseases, diseases of the lungs and respiratory tract, and the preparation thereof.

Bicyclic heterocycles, pharmaceutical compositions containing them, their use, and processes for preparing them

A compound of formula (I) wherein: Ra is a benzyl or 1-phenylethyl group or a phenyl group substituted by the groups R1 and R2, wherein: R1 is a hydrogen, fluorine, chlorine, or bromine atom, or a methyl, triflu

Aminoquinazolines which inhibit signal transduction mediated by tyrosine kinases

Compounds of the formula having an inhibitory effect on signal transduction mediated by tyrosine kinases, and the use thereof for treating diseases, particularly tumoral diseases, diseases of the lungs and respiratory tract.