290305-62-3

Upstream product

• 75-77-4 chloro-trimethyl-silane 

Downstream Products

• 290305-64-5 1-ethoxy-4-benzyloxy-1,3-bis(trimethylsilyloxy)buta-1,3-diene 
• 339220-42-7 3-benzoyloxy-4-benzyloxy-5-[Z-(ethoxycarbonylmethylidene)]-2-furanone 
• 339220-38-1 4-benzyloxy-5-[Z-(ethoxycarbonylmethylidene)]-3-hydroxy-2-furanone 

Relevant academic research and scientific papers

Efficient synthesis of γ-alkylidenetetronic esters by sequential lewis acid catalyzed [3 + 2] cyclizations and palladium-catalyzed cross-coupling reactions

A new approach for the synthesis of γ-alkylidenetetronic acids and esters is reported which involves Me3SiOTf-catalyzed, regio- and stereoselective cyclization of 4-alkoxy-1,3-bis(trimethylsilyloxy)-1,3-butadienes with oxalyl chloride. The α-hydroxy group of the butenolides is efficiently functionalized by palladium-catalyzed cross-coupling reactions via the corresponding enol triflates.