290305-64-5

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 290305-62-3 (Z)-4-Benzyloxy-3-trimethylsilanyloxy-but-2-enoic acid ethyl ester 
• 67354-34-1 ethyl 4-benzyloxyacetoacetate 
• 100-51-6 benzyl alcohol 
• 638-07-3 ethyl (2-chloroaceto)acetate 

Downstream Products

• 339220-38-1 4-benzyloxy-5-[Z-(ethoxycarbonylmethylidene)]-3-hydroxy-2-furanone 
• 433299-75-3 ethyl 4-(benzyloxy)-3-oxo-4-(4-oxochroman-2-yl)butanoate 
• 1052277-85-6 methyl 2,4-dihydroxy-5-benzyloxy-6-(methoxycarbonylmethyl)benzoate 
• 339220-42-7 3-benzoyloxy-4-benzyloxy-5-[Z-(ethoxycarbonylmethylidene)]-2-furanone 

Relevant academic research and scientific papers

Efficient synthesis of γ-alkylidenetetronic esters by sequential lewis acid catalyzed [3 + 2] cyclizations and palladium-catalyzed cross-coupling reactions

A new approach for the synthesis of γ-alkylidenetetronic acids and esters is reported which involves Me3SiOTf-catalyzed, regio- and stereoselective cyclization of 4-alkoxy-1,3-bis(trimethylsilyloxy)-1,3-butadienes with oxalyl chloride. The α-hydroxy group of the butenolides is efficiently functionalized by palladium-catalyzed cross-coupling reactions via the corresponding enol triflates.

New and regioselective synthesis of 4-ylidene-tetronic acids by Lewis- acid catalyzed cyclization of 4-alkoxy-bis-(trimethylsiloxy)-1,3-dienes with oxalyl chloride

A new approach for the synthesis of 4-ylidene-tetronic acids is reported which involves Me3SiOTf-catalyzed, regio- and stereoselective cyclization of 4-alkoxy-bis-(trimethylsiloxy)-1,3-dienes with oxalyl chloride and subsequent chemoselective deprotection of the 3-hydroxy-group.