2905-67-1

Usage

Uses

Used in Organic Synthesis:
3,5-Dichlorobenzoic Acid Methyl Ester is used as a synthetic intermediate for the production of various organic compounds. Its unique structure allows it to be a versatile building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3,5-Dichlorobenzoic Acid Methyl Ester is used as a key component in the synthesis of certain drugs. Its chemical properties make it a valuable precursor for the development of new medications with potential therapeutic applications.
Used in Agrochemical Industry:
3,5-Dichlorobenzoic Acid Methyl Ester is also utilized in the agrochemical industry, where it serves as a starting material for the synthesis of various pesticides and herbicides. Its reactivity and stability contribute to the creation of effective crop protection products.
Safety Considerations:

InChI:InChI=1/C8H6Cl2O2/c1-12-8(11)5-2-6(9)4-7(10)3-5/h2-4H,1H3

Upstream product

• 67-56-1 methanol 
• 2905-62-6 3,5-dichlorobenzoyl chloride 
• 91085-56-2 3,5-dichlorobenzoic acid ethyl ester 
• 17287-03-5 trimethylsulphonium hydroxide 
• 10203-08-4 3,5-dichlorobenzaldehyde 
• 51-36-5 3,5-dichlorobenzoic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 25186-47-4 3,5-dichlorotoluene 
• 186581-53-3 diazomethane 

Downstream Products

• 60211-57-6 3,5-dichlorobenzyl alcohol 
• 943436-52-0 1-(3,5-dichlorophenyl)-2,2,2-trifluoro-1-trimethylsilyloxy-1-methoxyethane 
• 924887-13-8 C₂₀H₁₄Cl₂O₃ 
• 845781-25-1 1-(3,5-dichlorophenyl)-2-phenylethan-1-one 
• 1267952-21-5 2,4-dichloro-6-hydroxymethylnitrobenzene 
• 1267952-23-7 2,4-dichloro-6-methoxymethylnitrobenzene 
• 569328-81-0 (5-chloro-3-methoxymethyl-2-nitrophenyl)(4,6-dimethoxypyrimidin-2-yl)ketone 
• 569328-84-3 (5-chloro-3-methoxymethyl-2-nitrophenyl)(4,6-dimethoxypyrimidin-2-yl)acetonitrile 
• 1211800-73-5 C₁₃H₁₆BClO₄ 
• 1192765-28-8 methyl 3,5-bis(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)benzoate 
• 2905-65-9 methyl 3-chlorobenzoate 
• 327056-71-3 3-chloro-5-cyanobenzoic acid 
• 33244-92-7 3,5-dichloro-N-methylbenzamide 

Relevant academic research and scientific papers

The effect of indium(III) triflate in oxone-mediated oxidative methyl esterification of aldehydes

An oxidative methyl esterification of aldehydes was effectively achieved. The trivalent indium reagent, indium(III) triflate, was revealed to accelerate the reactions in many cases. Aromatic aldehydes with various substituents were subjected to this method, and each produced the corresponding methyl esters in good to excellent yields within a relatively short reaction time.

METHOD FOR PRODUCTION OF 3-HYDROXYPROPAN-1-ONE COMPOUND, METHOD FOR PRODUCTION OF 2-PROPEN-1-ONE COMPOUND, AND METHOD FOR PRODUCTION OF ISOXAZOLINE COMPOUND

There is provided a novel intermediate for producing pesticides. A method for producing 1,3-bis(substituted phenyl)-3-substituted-3-hydroxypropan-1-one compound of Formula (3) comprises reacting an aromatic ketone compound of Formula (4) and a substituted acetophenone compound of Formula (5) as starting raw materials in an organic solvent or water in the presence or absence of an additive in the presence of a base in a suspended state. A method for producing 1,3-bis(substituted phenyl)-3-substituted-2-propen-2-one compound of Formula (2) comprises dehydrating the compound of Formula (3). A method for producing compound (2) in one step comprises reacting compound (4) and compound (5) to obtain compound (3). Further, a method for producing an isoxazoline compound of Formula (1) comprises reacting compound (2) and a hydroxylamine in an aliphatic or an aromatic hydrocarbon solvent which is optionally substituted by a halogen atom by adding an additive selected from a phase-transfer catalyst, a C1-C6 alcohol and an aprotic polar solvent in the presence of a base and water.

Electroreduction of organic compounds, 36 [1]. Electroreduction of chlorinated methyl benzoates

The preparative electroreduction of the three methyl monochlorobenzoates, the six methyl dichlorobenzoates, and methyl 2,3,4-trichlorobenzoate in different solvent-supporting electrolytes (SSE) was studied. The rate of the dechlorination, which is the main reaction, is dependent on the substitution pattern. Pronounced regioselectivity is therefore observed in case of the oligochloro derivatives. Hydrogenation of the benzene ring and reduction of the methoxycarbonyl group with formation of a hydroxymethyl group are observed as side-reactions. Quantum chemical calculations on the reaction mechanism were performed. The theoretical results are in accordance with the experimental observations.

1,3-BIS(SUBSTITUTED PHENYL)-3-HYDROXYPROPAN-1-ONE OR 2-PROPEN-1-ONE COMPOUND, AND SALT THEREOF

There is provided a novel process intermediate represented by the general formula (1) or (2): (where, X represents halogen atom, cyano group or the like, Y represents halogen atom, cyano group or the like, R1 represents C1-C6/s

DIARYLTRIAZOLES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1

2,5-Diaryl-1,2,4-triazole derivatives of structural formula I are selective inhibitors of the 11β-hydroxysteroiddehydrogenase Type 1 enzyme (11β-HSD-1). The compounds are useful for the treatment of diabetes, hyperglycemia, obesity,insulin resistance, atherosclerosis, dyslipidemia, hyperlipidemia, hypertension, and Metabolic Syndrome. Also disclosed are novel compounds of structural formula II which are inhibitors of 11β-HSD-1

Method for preparing aromatic compounds

A method for synthesizing aromatic compounds by selectively dehalogenating aromatic starting materials is provided. Compounds may be prepared which are substituted with fluoro, chloro or bromo. The method may be used to remove halogen atoms from sites at which halogenation is not desired, and to form substantially pure halogenated compounds from mixtures of starting materials. The method uses a copper containing dehalogenation agent and an acid with the dehalogenation being controlled by a substituent such as a carboxylic acid, amide, ester, aldehyde, ketone or cyano on the aromatic ring.

Method for preparing aromatic compounds

A method for synthesizing aromatic compounds by selectively dehalogenating aromatic starting materials is provided. Compounds may be prepared which are substituted with fluoro, chloro or bromo. The method may be used to remove halogen atoms from sites at which halogenation is not desired, and to form substantially pure halogenated compounds from mixtures of starting materials. The method uses a copper containing dehalogenation agent and an acid with the dehalogenation being controlled by a substituent such as a carboxylic acid, amide, ester, aldehyde, ketone or cyano on the aromatic ring.

Natural formation of chlorobenzoic acids (CBA) and distinction between PCB-degraded CBA

Mono- and dichlorobenzoic acid (CBA) could be found in samples of remote bog pond water and sediment. The 2,4-CBA always had the highest concentrations. In bog water samples the concentrations ranged between 0.11 and 0.48 μg/l. Besides 2,4-CBA most only 2,5-CBA could be found as dichlorobenzoic acid. In all samples we could detect also trichloroacetic acid (TCAA). The TCAA concentrations correlate with the CBA concentrations. As TCAA is known as a naturally produced organohalogen, this correlation can be seen as an indication to a natural formation of CBA. A confirmation of this presumption is our detection CBA in a reaction of benzoic acid with the chlorinating enzyme chloroperoxidase (CPO).

Dehydrohalogenation of (polyhaloalkyl)benzenes

A process for the dehydrohalogenation of a (polyhaloalkyl)benzene containing a benzylic halogen such as 1,3-dichloro-5-(2,4,4,4-tetrachlorobutyl)benzene by contacting the (polyhaloalkyl)benzene with a suitably active Lewis acid catalyst such as SbCl5 or TiCl4 under conditions sufficient to catalyze said dehydrohalogenation to form a (polyhaloalkenyl)benzene such as 3,5-dichloro-α-(2,2,2-trichloroethyl)styrene.