2905-68-2

Usage

Uses

Used in Chemical Synthesis:
METHYL 3,4-DICHLOROBENZOATE is used as an intermediate compound for the synthesis of other chemical compounds. Its unique structure with a methyl ester and two chlorine atoms at the 3rd and 4th positions allows it to be a valuable building block in the creation of various organic compounds. The specific applications and industries where it is used may vary, but its role in chemical synthesis is significant.

InChI:InChI=1/C8H6Cl2O2/c1-12-8(11)5-2-3-6(9)7(10)4-5/h2-4H,1H3

Upstream product

• 67-56-1 methanol 
• 51-44-5 3,4-dichlorbenzoic acid 
• 598-99-2 Methyl trichloroacetate 
• 17287-03-5 trimethylsulphonium hydroxide 
• 28394-58-3 3,4-dichloro-benzoic acid ethyl ester 
• 74-88-4 methyl iodide 
• 107-06-2 1,2-dichloro-ethane 
• 89978-33-6 methyl 2,3,4-trichlorobenzoate 
• 1805-32-9 3,4-dichlorobenzyl alcohol 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 6287-38-3 3,4-dichlorobenzaldehyde 
• 75-91-2 tert.-butylhydroperoxide 
• 3024-72-4 3,4-dichlorobenzoyl chloride 

Downstream Products

• 28036-91-1 3,4-dichlorobenzohydrazide 
• 4640-68-0 3,4-dichlorobenzoyl acetonitrile 
• 109272-24-4 1,2-Dichloro-4-(tris-methylsulfanyl-methyl)-benzene 
• 2459-10-1 benzene-1,2,4-tricarboxylic acid trimethyl ester 
• 122884-23-5 1-(3,4-Dichloro-phenyl)-2-[1-phenyl-imidazolidin-(2E)-ylidene]-ethanone 
• 2905-65-9 methyl 3-chlorobenzoate 
• 51-44-5 3,4-dichlorbenzoic acid 
• 1333392-71-4 3,4-dichloro-[N'-(benzofuroxan-5-yl)methylene]benzohydrazide 
• 1620567-90-9 4-(4-methylpiperazin-1-yl)-6-(3,4-dichlorophenyl)-1,3,5-triazin-2-amine 

Relevant academic research and scientific papers

Rational principles for modulating fluorescence properties of fluorescein

Rational design strategies based on practical fluorescence modulation mechanisms would enable us to rapidly develop novel fluorescence probes for target molecules. Here, we present a practical and general principle for modulating the fluorescence properti

COMPOUNDS, COMPOSITIONS AND METHODS OF USE

Herein, compounds, compositions and methods for modulating inclusion formation and stress granules in cells related to the onset of neurodegenerative diseases, musculoskeletal diseases, cancer, ophthalmological diseases, and viral infections are described.

Site-Selective Cross-Coupling of Remote Chlorides Enabled by Electrostatically Directed Palladium Catalysis

Control of site-selectivity in chemical reactions that occur remote from existing functionality remains a major challenge in synthetic chemistry. We describe a strategy that enables three of the most commonly used cross-coupling processes to occur with high site-selectivity on dichloroarenes that bear acidic functional groups. We have achieved this by repurposing an established sulfonylated phosphine ligand to exploit its inherent bifunctionality. Mechanistic studies suggest that the sulfonate group engages in attractive electrostatic interactions with the cation associated with the deprotonated substrate, guiding cross-coupling to the chloride at the arene meta position. This counterintuitive combination of anionic ligand and anionic substrate demonstrates an alternative design principle when considering the application of noncovalent interactions to direct catalysis.

Ni-Catalyzed chemoselective alcoholysis of: N -acyloxazolidinones

Although N-acyloxazolidinone-based (catalytic) asymmetric synthetic methodologies occupy an important position in modern organic synthesis, the catalytic cleavage of a chiral auxiliary remains underdeveloped. We report the Ni(cod)2/bipyr.-catalyzed alcoholysis of N-acyloxazolidinones to deliver esters. The reaction is broad in scope for both N-acyloxazolidinone substrates and alcohol nucleophiles, and displays good functional group tolerance and excellent chemoselectivity. A gram-scale methanolysis allowed the enantioselective synthesis of the C22-C26 segment of a close analogue of the potent immunosuppressant agent FK506.

Azabicyalo derivative as well as preparation and application thereof

The invention relates to an azabicyalo derivative as well as preparation and application thereof, and particularly discloses a compound with a structure shown in to the formula (A) or salt thereof acceptable in agricultural pharmacology. The compound in the formula (A) is described in the description in detail, and has an excellent killing effect on nematode.

Ultrasound assisted direct oxidative esterification of aldehydes and alcohols using graphite oxide and Oxone

A sonochemical procedure for direct oxidative esterification of aldehydes and alcohols using graphite oxide and Oxone in an alcoholic solvent is described. Mild reaction conditions, short reaction times, cost-effectiveness, and facile isolation of the products make the present system as a practical method.

Calcium and magnesium chlorides-catalyzed oxidative esterification of aromatic aldehydes

An interesting procedure for the oxidative esterification of aromatic aldehydes has been developed. By using catalytic amount of CaCl2 or MgCl2, various methyl benzoates were isolated in good yields with hydrogen peroxide as the terminal oxidant.

Copper-catalyzed methyl esterification of aromatic aldehydes and benzoic alcohols by TBHP as both oxidant and methyl source

A copper-catalyzed synthesis of methyl esters from aromatic aldehydes in the presence of tert-butyl hydrogen peroxide (TBHP) was developed via a radical reaction mechanism. TBHP acts not only as an efficient oxidant, but also as a green methyl source in such transformation. Moreover, this method could also be efficiently extended to the methyl esterification of benzylic alcohols.

Synthesis, antibacterial activities, and 3d-qsar of sulfone derivatives containing 1, 3, 4-oxadiazole moiety

A series of sulfone derivatives containing 1, 3, 4-oxadiazole moiety were prepared and evaluated for their antibacterial activities by the turbidimeter test. Most compounds inhibited growth of Ralstonia solanacearum (R. solanacearum) from tomato and tobacco bacterial wilt with high potency, among which compounds 5a and 5b exhibited the most potent inhibition against R. solanacearum from tomato and tobacco bacterial wilts with EC50 values of 19.77 and 8.29 μg/mL, respectively. Our results also demonstrated that 5a, 5b, and a number of other compounds were more potent than commercial bactericides Kocide 3000 and Thiodiazole Copper, which inhibited R. solanacearum from tomato bacterial wilt with EC50 values of 93.59 and 99.80 μg/mL and tobacco bacterial wilt with EC50 values of 45.91 and 216.70 μg/mL, respectively. The structure-activity relationship (SAR) of compounds was studied using three-dimensional quantitative structure-activity relationship (3D-QSAR) models created by comparative molecular field analysis (CoMFA) and comparative molecular similarity index analysis (CoMSIA) based on compound bioactivities against tomato and tobacco bacterial wilts. The 3D-QSAR models effectively predicted the correlation between inhibitory activity and steric-electrostatic properties of compounds.

Novel benzofuroxan derivatives against multidrug-resistant Staphylococcus aureus strains: Design using Topliss' decision tree, synthesis and biological assay

The aim of this study was the design of a set of benzofuroxan derivatives as antimicrobial agents exploring the physicochemical properties of the related substituents. Topliss' decision tree approach was applied to select the substituent groups. Hierarchical cluster analysis was also performed to emphasize natural clusters and patterns. The compounds were obtained using two synthetic approaches for reducing the synthetic steps as well as improving the yield. The minimal inhibitory concentration method was employed to evaluate the activity against multidrug-resistant Staphylococcus aureus strains. The most active compound was 4-nitro-3-(trifluoromethyl)[N′-(benzofuroxan-5-yl) methylene]benzhydrazide (MIC range 12.7-11.4 μg/mL), pointing out that the antimicrobial activity was indeed influenced by the hydrophobic and electron-withdrawing property of the substituent groups 3-CF3 and 4-NO2, respectively.