29064-82-2

Basic information

• Product Name: 3-BROMO-4-CHLOROTHIENO[3,2-C]PYRIDINE
• Synonyms: 3-BROMO-4-CHLOROTHIENO[3,2-C]PYRIDINE;3-BroMo-4-chlorothieno[3,...
• CAS NO: 29064-82-2
• Molecular Formula: C₇H₃BrClNS
• Molecular Weight: 248.53
• Product Categories: Heterocycle-Pyridine series
• Mol File: 29064-82-2.mol

Chemical Properties

• Melting Point: 161-163℃
• Boiling Point: 355.2±37.0 °C(Predicted)
• Appearance: /
• Density: 1.849
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: -1.47±0.40(Predicted)
• CAS DataBase Reference: 3-BROMO-4-CHLOROTHIENO[3,2-C]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-4-CHLOROTHIENO[3,2-C]PYRIDINE(29064-82-2)
• EPA Substance Registry System: 3-BROMO-4-CHLOROTHIENO[3,2-C]PYRIDINE(29064-82-2)

Safety Data

• Hazard Codes: T
• Statements: 25-36
• Safety Statements: 26-45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 29064-82-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Bromo-4-chlorothieno[3,2-c]pyridine is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to be incorporated into the molecular structures of potential drugs. Its unique properties allow for the creation of compounds with specific therapeutic effects, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Bromo-4-chlorothieno[3,2-c]pyridine serves as a precursor in the development of new pesticides and other agrochemicals. Its reactivity and structural features enable the design of molecules with targeted biological activities, enhancing crop protection and management strategies.
Used in Organic Synthesis:
3-Bromo-4-chlorothieno[3,2-c]pyridine is utilized as a versatile building block in organic synthesis, allowing chemists to construct complex organic compounds with diverse applications. Its presence in these syntheses can lead to the discovery of new materials with unique properties and uses.
Used in Research Laboratories:
As a reagent for chemical reactions, 3-Bromo-4-chlorothieno[3,2-c]pyridine is employed in research settings to explore its reactivity and to develop new synthetic methodologies. It also serves as a starting material for the preparation of more complex compounds, facilitating the study of structure-activity relationships and the discovery of novel chemical entities.

Upstream product

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• 799293-81-5 trans-3-(4-bromothiophen-2-yl)-acryloyl azide 
• 799293-83-7 3-bromo-4-hydroxy-[3,2-c]-thienopyridine 

Downstream Products

• 799293-85-9 3-bromo-4-amino-[3,2-c]-thienopyridine 

Relevant articles and documents

NEW BICYCLIC DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Compounds of formula (I); wherein R1, R2, R3, R4, R5, R6, R7, R8, R14, W, A and n are as defined in the description. Medicaments.

Improved synthesis of 3-substituted-4-amino-[3,2-c]-thienopyridines

(Chemical Equation Presented) Two syntheses of 3-substituted-4-amino-[3,2- c]thienopyridines have been developed to replace the standard literature route to these compounds, which uses unattractive conditions involving azide and high temperatures. The fir

Design and effective synthesis of novel templates, 3,7-diphenyl-4-amino-thieno and furo-[3,2-c]pyridines as protein kinase inhibitors and in vitro evaluation targeting angiogenetic kinases

A novel class of 3,7-diphenyl-4-amino-thieno and furo[3,2-c]pyridine has been designed based on pharmacophore models of ATP competitive kinase inhibitors. Versatile synthetic methods via double Suzuki coupling to explore SAR have been established and potent inhibitors against angiogenetic targets, VEGFR2, Tie-2, and EphB4, have been successfully discovered.

Discovery of thienopyridines as Src-family selective Lck inhibitors

We describe the identification, SAR, and in vivo pharmacology of a new series of Src-family selective Lck inhibitors. These thienopyridines were designed based on a desire to access the unique residues in the extended hinge region of Lck.

Thienopyridine urea inhibitors of KDR kinase

A series of substituted thienopyridine ureas was prepared and evaluated for enzymatic and cellular inhibition of KDR kinase activity. Several of these analogs, such as 2, are potent inhibitors of KDR (10 nM) in both enzymatic and cellular assays. Further

Thienopyridine and furopyridine kinase inhibitors

Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Thienopyridine kinase inhibitors

Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Thienopyridine and furopyridine kinase inhibitors

Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

NOVEL CHEMICAL COMPOUNDS

This invention relates to newly identified compounds for treating and preventing tumors ans cancers, and methods for treating proliferative diseases associated with the imbalance or inappropriate activity of tyrosine kinases implicated in proliferative diseases.