799293-83-7

Basic information

• Product Name: 3-broMo-4H,5H-thieno[3,2-c]pyridin-4-one
• Synonyms: 3-broMo-4H,5H-thieno[3,2-c]pyridin-4-one;3-BroMothieno[3,2-c]pyridin-4(5H)-one;3-broMo-4-hydroxy-[3,2-c]-thienopyridine;3-BROMO-4-HYDROXYTHIENO[3,2-C]PYRIDINE;3-Bromothieno[3,2-c]pyridin-4-ol;3-Bromothieno[3,2-c]pyridin-4(5H)
• CAS NO: 799293-83-7
• Molecular Formula: C₇H₄BrNOS
• Molecular Weight: 230.08176
• Mol File: 799293-83-7.mol

Chemical Properties

• Melting Point: 273-278°C
• Boiling Point: 468.6±45.0 °C(Predicted)
• Appearance: /
• Density: 1.801±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 12.09±0.20(Predicted)
• CAS DataBase Reference: 3-broMo-4H,5H-thieno[3,2-c]pyridin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-broMo-4H,5H-thieno[3,2-c]pyridin-4-one(799293-83-7)
• EPA Substance Registry System: 3-broMo-4H,5H-thieno[3,2-c]pyridin-4-one(799293-83-7)

Safety Data

• Hazard Codes: T,C
• Statements: 25-34-36
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3260 8 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 799293-83-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Bromo-4H,5H-thieno[3,2-c]pyridin-4-one is used as a building block for the synthesis of novel organic compounds with potential therapeutic properties. Its unique structure allows for the development of new drugs with improved efficacy and selectivity, targeting a wide range of diseases and conditions.
Used in Materials Science:
In the field of materials science, 3-bromo-4H,5H-thieno[3,2-c]pyridin-4-one can be utilized as a component in the design and synthesis of advanced materials with specific properties. Its incorporation into polymers, for instance, may lead to materials with enhanced stability, conductivity, or other desirable characteristics.
Used in Chemical Research:
3-Bromo-4H,5H-thieno[3,2-c]pyridin-4-one serves as a valuable subject for chemical research, particularly in exploring its potential biological activity. Further investigation may reveal its interactions with biological systems, opening up new avenues for drug discovery and development.
Used in Drug Synthesis:
As a key intermediate in the synthesis of various pharmaceutical compounds, 3-bromo-4H,5H-thieno[3,2-c]pyridin-4-one plays a crucial role in the development of new drugs. Its unique chemical properties enable the creation of molecules with specific therapeutic targets, potentially leading to more effective treatments for various diseases.

Upstream product

• 1150566-09-8 4-bromo-thiophene-3-carboxylic acid (2,2-dimethoxy-ethyl)-amide 
• 799293-81-5 trans-3-(4-bromothiophen-2-yl)-acryloyl azide 
• 16694-17-0 4-bromo-3-thiophenecarboxylic acid 
• 103686-16-4 trans-3-(4-bromothiophen-2-yl)propenoic acid 
• 18791-75-8 4-Bromothiophen-2-aldehyde 

Downstream Products

• 29064-82-2 3-bromo-4-chloro-[3,2-c]-thienopyridine 
• 799293-85-9 3-bromo-4-amino-[3,2-c]-thienopyridine 
• 799293-91-7 3-bromo-7-iodothieno[3,2-c]pyridin-4-amine 
• 799293-86-0 4-amino-3-(3-chloro-4-fluoro-phenyl)-thieno[3,2-c]pyridine 
• 799293-87-1 4-amino-7-bromo-3-(3-chloro-4-fluorophenyl)-thieno[3,2-c]pyridine 
• 799293-92-8 4-amino-3-bromo-7-(3,4,5-trimethoxyphenyl)thieno[3,2-c]pyridine 

Relevant articles and documents

Thermal synthesis of 3-bromothieno[3,2-c]pyridin-4-(5h)-one: A telescoped procedure with tributylamine

3-Bromothieno[3,2-c]pyridine-4-(5H)-one (1) was prepared from (2E)-3-(4-bromo-2-thienyl)-2- propenoic acid (3) by the Eloy-Deryckere thermal benzo/heteropyridinone synthesis. A telescoped procedure was developed, which reduces some of the risk associated with the classic procedure. Use of tributylamine as an additive in this process was shown to facilitate E/Z-isomerization of the intermediate vinyl isocyanate and lower the temperature necessary for the overall thermal process.

NEW BICYCLIC DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Compounds of formula (I); wherein R1, R2, R3, R4, R5, R6, R7, R8, R14, W, A and n are as defined in the description. Medicaments.

NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A

The present invention relates to novel compounds of the formula I which are inhibitors of phosphodiesterase type 10A and to their use for the manufacture of a medicament and which thus are suitable for treating or controlling of medical disorders selected from neurological disorders and psychiatric disorders, for ameliorating the symptoms associated with such disorders and for reducing the risk of such disorders

Improved synthesis of 3-substituted-4-amino-[3,2-c]-thienopyridines

(Chemical Equation Presented) Two syntheses of 3-substituted-4-amino-[3,2- c]thienopyridines have been developed to replace the standard literature route to these compounds, which uses unattractive conditions involving azide and high temperatures. The fir

Thienopyridine urea inhibitors of KDR kinase

A series of substituted thienopyridine ureas was prepared and evaluated for enzymatic and cellular inhibition of KDR kinase activity. Several of these analogs, such as 2, are potent inhibitors of KDR (10 nM) in both enzymatic and cellular assays. Further

Design and effective synthesis of novel templates, 3,7-diphenyl-4-amino-thieno and furo-[3,2-c]pyridines as protein kinase inhibitors and in vitro evaluation targeting angiogenetic kinases

A novel class of 3,7-diphenyl-4-amino-thieno and furo[3,2-c]pyridine has been designed based on pharmacophore models of ATP competitive kinase inhibitors. Versatile synthetic methods via double Suzuki coupling to explore SAR have been established and potent inhibitors against angiogenetic targets, VEGFR2, Tie-2, and EphB4, have been successfully discovered.

Discovery of thienopyridines as Src-family selective Lck inhibitors

We describe the identification, SAR, and in vivo pharmacology of a new series of Src-family selective Lck inhibitors. These thienopyridines were designed based on a desire to access the unique residues in the extended hinge region of Lck.

Thienopyridine and furopyridine kinase inhibitors

Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Thienopyridine and furopyridine kinase inhibitors

Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.