2907-85-9

Usage

Uses

Used in Pharmaceutical Industry:
(2-Oxotetrahydrofuran-3-yl)phosphonic acid diethyl ester is used as a reagent for the synthesis of pharmaceuticals, due to its versatile reactivity and ability to participate in various chemical reactions.
Used in Agrochemical Industry:
(2-Oxotetrahydrofuran-3-yl)phosphonic acid diethyl ester is used as a reagent for the synthesis of agrochemicals, due to its versatile reactivity and ability to participate in various chemical reactions.
Used in Materials Science:
(2-Oxotetrahydrofuran-3-yl)phosphonic acid diethyl ester is used as a reagent for the synthesis of materials, due to its versatile reactivity and ability to participate in various chemical reactions.
Used in Coordination Chemistry:
(2-Oxotetrahydrofuran-3-yl)phosphonic acid diethyl ester is used as a ligand in coordination chemistry, due to the presence of the phosphonic acid group.

InChI:InChI=1/C8H15O5P/c1-3-12-14(10,13-4-2)7-5-6-11-8(7)9/h7H,3-6H2,1-2H3

Upstream product

• 96-48-0 4-butanolide 
• 589-57-1 diethyl phosphorylchloridite 
• 814-49-3 diethyl chlorophosphate 
• 5061-21-2 α-bromo-γ-butyrolactone 
• 122-52-1 triethyl phosphite 

Downstream Products

• 547-65-9 α-methylene-γ-butyrolactone 
• 144736-14-1 2-(3-methyl-5-(2,6,6-trimethyl-1-cyclohexenyl)-2,4-pentadienylidene)-γ-butyrolactone 
• 108071-20-1 α-diethoxyphosphinyl-α-phenylseleno-γ-butyrolactone 
• 138175-72-1 (E)-methyl 2-<1'-<2''-(2''',2'''-dimethoxyethyl)-1'',3''-dithian-2''-yl>-2'-<(E)-2''''-oxotetrahydrofuran-3-ylidene>ethoxymethyl>-3-dimethyl(phenyl)silylprop-2-enoate 
• 138175-87-8 (E)-methyl 2-<1'-<2''-(2''',2'''-dimethoxyethyl)-1'',3''-dithian-2''-yl>-2'-<(Z)-2''''-oxotetrahydrofuran-3-ylidene>ethoxymethyl>-3-dimethyl(phenyl)silylprop-2-enoate 
• 43142-58-1 3-ethylidenedihydro-2(3H)-furanone 
• 43142-59-2 (Z)-α-ethylidene-γ-butyrolactone 
• 52216-89-4 (Z)-α-propylidene-γ-butyrolactone 
• 52216-90-7 (E)-α-propylidene-γ-butyrolactone 
• 444760-00-3 3-[(4Z,6E)-(2R,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-2,4,6-trimethyl-7-(4-nitro-phenyl)-hepta-4,6-dien-(Z)-ylidene]-dihydro-furan-2-one 

Relevant academic research and scientific papers

Stereocontrol in Horner-Wadsworth-Emmons Condensations of α-Phosphono Lactones with Aldehydes: A Synthesis of Integerrinecic Acid and Senecic Acid Lactones

The Horner-Wadsworth-Emmons condensations of α-phosphono lactones were investigated under a variety of conditions.Upon treatment with KHMDS and 18-crown-6 in THF, condensations of the five-membered ring phosphono lactones 7a and 8 with propionaldehyde afforded the E olefins cleanly.In contrast, these phosphonates gave predominantly the Z olefins upon treatment with propionaldehyde, K2CO3 and 18-crown-6 in THF.A similar, though somewhat less-pronounced trend was observed with the six-membered ring phosphono lactone 9a.However, in its condensation with acetaldehyde the more functionalized phosphono lactone 4 gave the best E selectivity (ca. 9:1) when DBU/CH3CN was used, providing the methyl ester of integerrinecic acid lactone (5) in 77percent isolated yield.When K2CO3/18-crown-6/toluene was employed in a parallel reaction, only slight selectivity for the Z isomer was observed, but the methyl ester of senecic acid lactone (6) still was obtained in 43-46percent yield from the product mixture.

SUBSTITUTED IMIDAZOLECARBOXAMIDE AS BRUTON'S TYROSINE KINASE INHIBITORS

The disclosure relates to a series of substituted imidazolecarboxamide compounds of formula I as BTK (Bruton's Tyrosine Kinase) inhibitors, and the methods of using the same for the treatment of autoimmune disease, inflammatory disease, cancer and potenti

Novel synthesis of physovenine and physostigmine analogs

This Letter describes a versatile synthetic approach to prepare physovenine and physostigmine analogs. A series of analogs were synthesized and evaluated for cholinesterase inhibition activities, including human acetylcholinesterase (AChE) and butyrylchol

Base-catalyzed ethanolysis of α-diethoxyphosphoryl-γ-lactones: A facile synthesis of cyclopropanecarboxylates

A range of alkyl- and alkenylcyclopropanecarboxylic acid ethyl esters has been stereoselectively prepared by treatment of substituted α- diethoxyphosphoryl-γ-lactones with sodium ethoxide in tetrahydrofuran. Georg Thieme Verlag Stuttgart.

7-AMINO ALKYLIDENYL-HETEROCYCLIC QUINOLONES AND NAPHTHYRIDONES

The present invention relates to compounds having a structure according to Formula I wherein n, m, z, R, R2, R3, R4, R5, R6, A, E, X, Y a and b are as defined above; or an optical isomer, diastereomer or enantiomer thereof; a pharmaceutically acceptable s

Asthma associated factors as targets for treating atopic allergies including asthma and related disorders

This invention relates to methods for treating asthma or allergy in a mammal by administering a 3-aminosteroid compound to a mammal in need thereof. The 3-aminosteroid compound being capable of down regulating the IL-9 pathway and alleviating asthmatic responses to allergen. Exemplary aminosteroid compounds used in the methods of the invention include compounds having the chemical formula (I), wherein X, R1, R2, R3, and R4 groups arc as defined herein. ‘T’ he invention also relates to certain novel compound of formula (I). Moreover, the invention also provides methods for identifying an immunomodulatory 3-aminosteroid compound.

Intramolecular termination of radical-polar crossover reactions

Cyclic ethers result from intramolecular trapping of cations formed through the radical-polar crossover process.

An enantiocontrolled synthesis of pyrrolizidines, (-)-platynecine and (-)-hadinecine

Trisubstituted allylic alcohols 13 and 14 have been converted into a single isomeric trans-oxazoline 16 via an intramolecular iodoamidation of the corresponding trichloroacetimidates, which have been elaborated into (-)-platynecine 1 and(-)-hadinecine 2 via a common intermediate pyrrolizidine.

Termination of radical-polar crossover reactions by intramolecular nucleophiles

Radical-polar crossover reactions featuring intramolecular nucleophilic termination are reported.

A CONVENIENT PREPARATION OF α-PHOSPHONO ESTERS AND LACTONES VIA C-P BOND FORMATION

The reaction of ester and lactone enolates with diethyl phosphorochloridite, followed by air oxidation of the immediate reaction products, has proven to be a general alternative to the traditional Arbuzov synthesis of α-phosphono esters and lactones.