29076-84-4

Upstream product

• 2157-50-8 propiophenone oxime 
• 925-90-6 ethylmagnesium bromide 
• 100-47-0 benzonitrile 
• 5311-88-6 propanal N-phenylhydrazone 
• 588-64-7 benzaldehyde phenylhydrazone 
• 74-96-4 ethyl bromide 
• 7664-41-7 ammonia 
• 93-55-0 1-phenyl-propan-1-one 
• 64-17-5 ethanol 
• 2941-20-0 1-phenylpropylamine 
• 107-12-0 propiononitrile 
• 93-54-9 1-Phenyl-1-propanol 
• 932-90-1 syn-benzaldehyde oxime 
• 60-29-7 diethyl ether 

Downstream Products

• 102025-12-7 2-benzoylamino-2-phenyl-butyronitrile 
• 79402-71-4 N-(1-phenylpropylidene)acetamide 
• 28150-00-7 Propiophenon-benzophenonazin 
• 72379-99-8 bis-(1-phenyl-propylidene)-hydrazine 
• 99408-66-9 3,5-diphenyl-4-aza-2,4-heptadiene 
• 117096-02-3 3,5-dimethyl-2,4-diphenyl-6-p-tolylpyridine 
• 117096-03-4 3,5-dimethyl-2,6-diphenyl-4-p-tolylpyridine 
• 117096-06-7 2-(4-Methoxy-phenyl)-3,5-dimethyl-4,6-diphenyl-pyridine 
• 117096-07-8 4-(4-Methoxy-phenyl)-3,5-dimethyl-2,6-diphenyl-pyridine 
• 85046-72-6 N-[1-Methyl-prop-(E)-ylidene]-N'-[1-phenyl-prop-(E)-ylidene]-hydrazine 
• 85046-71-5 N-Isopropylidene-N'-[1-phenyl-prop-(E)-ylidene]-hydrazine 
• 61209-15-2 Ethylphenylketimino-di-n-propylboran 
• 54948-31-1 (Ethylphenylketimino)-di-n-butylboran 
• 135455-28-6 {Os(C₆H₃(CH₃)3)(P(C(CH₃)3)2CH₃)(NC(C₆H₅)CH₂CH₃)}⁽¹⁺⁾*PF₆^(1-)={Os(C₆H₃(CH₃)3)(P(C(CH₃)3)2CH₃)(NC(C₆H₅)CH₂CH₃)}PF₆ 

Relevant academic research and scientific papers

Hydrogen bond directed aerobic oxidation of amines via photoredox catalysis

An application of H-bonding interactions for directing the α-C-H oxidation of amines to amides and amino-ketones catalyzed by an organic photocatalyst is reported. The high efficiency of this method is demonstrated by the aerobic oxidation of pyrrolidines, diarylamines and benzylamines bearing urea groups with high yields and a wide substrate scope.

Organocatalytic Enantioselective Synthesis of Tetrahydrofluoren-9-ones via Vinylogous Michael Addition/Henry Reaction Cascade of 1,3-Indandione-Derived Pronucleophiles

An unprecedented organocatalytic enantioselective vinylogous Michael addition/Henry cyclization cascade is presented for the synthesis of highly substituted tetrahydrofluoren-9-ones 3 employing novel 1,3-indandione-derived pronucleophiles 1a-g and nitroalkenes 2. Following a very simple protocol, a wide range of products were obtained in good to excellent yields and with excellent enantioinduction (43-98% yield, up to 98% ee). The reaction proceeded with excellent diastereocontrol despite the simultaneous generation of four stereogenic centers. Surprisingly, when 2-(1-phenylethylidene)-1H-indandione (1h) was used as a pronucleophile, no cyclization was observed, and only Michael addition adducts 4a-x were furnished in very good yields and excellent enantioselectivities. (Chemical Equation Presented).

CATALYTIC PREPARATION OF ENAMIDES FROM ALKYL AZIDES AND ACYL DONORS

The present invention relates to a method to synthesize an enamide compound by generating imine which does not have a substituent group bonded to the nitrogen from an organic azide compound and conducting a reaction of the same with acyl doner. By using t

Exploiting the Nucleophilicity of N-H Imines: Synthesis of Enamides from Alkyl Azides and Acid Anhydrides

The nucleophilicity of N-unsubstituted imines, which were generated from alkyl azides by a ruthenium-catalyzed reaction, was investigated in the reaction with acid anhydrides. The initial products were N-acylimines, which isomerized to the corresponding e

Tailoring D-amino acid oxidase from the pig kidney to r-stereoselective amine oxidase and its use in the deracemization of α-methylbenzylamine

The deracemization of racemic amines to yield enantioenriched amines using S-stereoselective amine oxidases (AOx) has recently been attracting attention. However, R-stereoselective AOx that are suitable for deracemization have not yet been identified. An R-stereoselective AOx was now evolved from porcine kidney D-amino acid oxidase (pkDAO) and subsequently use for the deracemization of racemic amines. The engineered pkDAO, which was obtained by directed evolution, displayed a markedly changed substrate specificity towards R?amines. The mutant enzyme exhibited a high preference towards the substrate α- methylbenzylamine and was used to synthesize the S?amine through deracemization. The findings of this study indicate that further investigations on the structure-activity relationship of AOx are warranted and also provide a new method for biotransformations in organic synthesis. A change in selectivity: An engineered porcine kidney D-amino acid oxidase (pkDAO) with markedly changed substrate selectivity towards R?amines was obtained by directed evolution. The mutant enzyme exhibited a high preference towards the substrate α-methylbenzylamine and was used to synthesize the S-configured amine through deracemization.

A convenient synthesis of tertiary carbinamines via N-aluminum ketimines

Reaction of N-unsubstituted ketimines with organoaluminum reagents prepared from allylic and propargylic halides, allows to prepare, in good yields, tertiary carbinamines with three different groups (phenyl, alkyl and α-unsaturated group) on die tertiary carbon center.

Ruthenium Complex Catalyzed Selective Deoxygenation of Ketoximes to Ketimines

Ru3(CO)12 showed high catalytic activity for the deoxygenation of various ketoximes to the corresponding ketimines under carbon monoxide pressure (20 kg/cm2).For the deoxygenation of propiophenone oxime, ethyl phenyl ketimine was obtained in 100 percent yield.On the other hand, heptanal oxime which was aldoxime was dehydrated under the same conditions to the corresponding nitrile in 32 percent yield.