29083-05-4

Usage

Uses

Used in Organic Synthesis:
N-tert-Butyl-4-fluorobenzenesulfonamide is used as a reagent for the preparation of various pharmaceutical compounds, leveraging its unique structural features to facilitate the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, N-tert-Butyl-4-fluorobenzenesulfonamide is used as an intermediate in the synthesis of drugs, contributing to the development of new therapeutic agents.
Used in Heterocyclic Compounds Synthesis:
N-tert-Butyl-4-fluorobenzenesulfonamide is used as a mild base in the synthesis of heterocyclic compounds, enabling the formation of diverse ring systems that are important in medicinal chemistry.
Used in Agrochemicals Synthesis:
In the agrochemical industry, N-tert-Butyl-4-fluorobenzenesulfonamide is used as an intermediate in the synthesis of various agrochemicals, playing a role in the development of crop protection products.
Used in Dyes Synthesis:
N-tert-Butyl-4-fluorobenzenesulfonamide is also used in the synthesis of dyes, where its chemical properties contribute to the creation of a variety of colorants for different applications.

Upstream product

• 349-88-2 4-Fluorobenzenesulfonyl chloride 
• 96042-30-7 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran 
• 402-46-0 4-fluorophenylsulphonamide 
• 84379-72-6 1,3-dioxoisoindolin-2-yl 3,3-dimethylbutanoate 
• 75-64-9 tert-butylamine 

Downstream Products

• 1418634-79-3 C₁₇H₁₆FNO₄S 
• 304649-69-2 4-hydrazino-2-hydroxymethyl-1-benzenesulfonamide 
• 304649-57-8 4-fluoro-2-hydroxymethyl-1-benzenesulfonamide 
• 304649-53-4 N-tert-butyl-4-fluoro-2-hydroxymethylbenzenesulfonamide 

Relevant academic research and scientific papers

Organophotoredox-Catalyzed Decarboxylative N-Alkylation of Sulfonamides

We developed an organophotoredox-catalyzed reaction for N-alkylation of sulfonamides with aliphatic carboxylic acid-derived redox active esters as alkylating reagents. Under mild and transition metal-free conditions, a series of functionalized N-alkylated sulfonamides were prepared. This protocol also enabled the functionalization of pharmaceutical drugs bearing a sulfonamide or carboxylic acid moiety. This radical-mediated process allowed the assembly of three components including sulfonamides, redox active esters, and alkenes to yield complex sulfonamides in a one-pot manner.

Cobalt-Catalyzed Asymmetric Allylation of Cyclic Ketimines

A CoII/Box-catalyzed [Box=bis(oxazoline)] enantioselective addition of potassium allyltrifluoroborate to cyclic ketimines was developed, providing the corresponding chiral α-tertiary amines in high yields and with good enantioselectivity values. Alkoxycarbonyl- and alkyl-substituted saccharin-derived ketimines are suitable substrates for this allylation reaction. The product can be converted to complex molecules over several simple steps, including a precursor of MK-0371, which is a kinesin spindle protein inhibitor. In addition, this catalytic system showed a strong positive nonlinear effect.

Copper (II)/RuPHOX-Catalyzed Enantioselective Mannich-Type Reaction of Glycine Schiff Bases with Cyclic Ketimines

A Cu(II)/RuPHOX-catalyzed enantioselective Mannich-type reaction of glycine Schiff bases with cyclic ketimines was developed, affording chiral α,?-diamino acid derivatives in good yields with moderate to good ee and dr values. This provides an efficient methodology for furnishing chiral Cβ-tetrasubstituted α,β-diamino acid precursors. The catalytic system is compatible with a series of substrates. In addition, an interesting nonlinear effect of the catalyst's enantiomeric composition on reaction enantioselectivity was observed. (Figure presented.).

Copper-catalyzed asymmetric alkynylation of cyclic: N -sulfonyl ketimines

A Cu-catalyzed asymmetric alkynylation of cyclic N-sulfonyl ketimines was developed, providing the corresponding chiral α-tertiary amines with up to 98% ee. The method tolerates some variations in cyclic N-sulfonyl ketimine and alkyne scope. These products could be used in several transformations, in particular, the products of 6-membered cyclic N-sulfonyl ketimines could be easily converted to linear chiral α-tertiary amines. This asymmetric alkynylation provides an efficient, gram-scale, low-cost transition-metal catalyzed synthesis of chiral α-tetrasubstituted propargylamines.

Simple branched sulfur-olefins as chiral ligands for Rh-catalyzed asymmetric arylation of cyclic ketimines: Highly enantioselective construction of tetrasubstituted carbon stereocenters

New, simple, sulfinamide-based branched olefin ligands have been developed and successfully used in Rh-catalyzed asymmetric arylations of cyclic ketimines, providing efficient and highly enantioselective access to valuable benzosultams and benzosulfamidat

Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade

The present invention provides compounds of Formula (I): wherein A, B, C, G, and W1 have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are useful to treat thrombotic disorders. Also disclosed are pharmaceutical compositions comprising one or more compounds of Formula I, processes for preparing compounds of Formula I, and intermediates useful for preparing compounds of Formula I.