2909-19-5

Upstream product

• 3731-51-9 2-(Aminomethyl)pyridine 
• 89-95-2 2-methyl-benzyl alcohol 
• 100-52-7 benzaldehyde 
• 88328-13-6 1-phenyl-N-(2-(pyridin-2-yl)methyl)methanimine 
• 90-02-8 salicylaldehyde 

Downstream Products

• 1401696-19-2 1-[N-(2-pyridylmethyl),N-(2-hydroxybenzyl)amino]-3-[N′-(2-hydroxybenzyl),N′-(4-methylbenzyl)amino]propan-2-ol 
• 205313-75-3 2-(((2-hydroxybenzyl)(pyridin-2-ylmethyl)amino)methyl)-4-nitrophenol 
• 63671-68-1 N-(2-pyridylmethyl)-2-hydroxybenzylamine 
• 80767-78-8 {(2-Hydroxy-phenyl)-[(pyridin-2-ylmethyl)-amino]-methyl}-phosphonic acid 

Relevant academic research and scientific papers

Directed Hydroxylation of sp2 and sp3 C-H Bonds Using Stoichiometric Amounts of Cu and H2O2

The use of copper for C-H bond functionalization, compared to other metals, is relatively unexplored. Herein, we report a synthetic protocol for the regioselective hydroxylation of sp2 and sp3 C-H bonds using a directing group, stoichiometric amounts of Cu and H2O2. A wide array of aromatic ketones and aldehydes are oxidized in the carbonyl γ-position with remarkable yields. We also expanded this methodology to hydroxylate the β-position of alkylic ketones. Spectroscopic characterization, kinetics, and density functional theory calculations point toward the involvement of a mononuclear LCuII(OOH) species, which oxidizes the aromatic sp2 C-H bonds via a concerted heterolytic O-O bond cleavage with concomitant electrophilic attack on the arene system.

From fluorogens to fluorophores by elucidation and suppression of ultrafast excited state processes of a Schiff base

Strategies have been explored for developing strongly fluorescent species out of a weakly fluorescent Schiff base, 2-(((pyridin-2-ylmethyl)imino)methyl)phenol (salampy). The locally excited enolic state of salampy undergoes an intramolecular proton transf

Preparation method and application of Asymmetric N-O ligand and Ti, Zr and Hf complex

The invention discloses a preparation method and application of asymmetric N-O ligand and Ti, Zr and Hf complex. The preparation method of the complex comprises the following steps: preparing asymmetric N-O ligand from substituted salicylaldehyde with 2-(

Two Schiff base ligands for distinguishing ZnII/CdII sensing - Effect of substituent on fluorescent sensing

Two Schiff base ligands (HL1, HL2) were conveniently synthesised by one-step condensation between pyridine 2-ylmethanamine and 3-ethoxy-2-hydroxybenzenaldhyde (for HL1) or salicylaldehyde (for HL2) as fluorescent sensors for distinguishing sensing of Zn2+ or Cd2+. Both of the two fluorescent sensors present very weak emission at 463 nm (for HL1) or 453 nm (for HL2). For HL1, upon addition of Zn2+, the fluorescence intensity of HL1 enhanced and gradually red shifted to 493 nm with a green emission while addition of Cd2+ only induced enhancement of fluorescent intensity at 463 nm. For HL2, only addition of Zn2+ induced enhancement of fluorescence intensity, presenting a high Zn2+/Cd2+ selectivity. A Zn2+-induced red shift in fluorescent spectra of HL1 could be attributed to twisted intramolecular charge transfer (TICT) from the interaction between the Zn2+ ion and in situ formed ligand L1′ with the twisted structure in compound 1, which is absent in compound 2. The Zn2+/Cd2+ selectivity of fluorescent response for HL2 correlates with the Cd-HL2 and Zn-HL2 coordination bond distances. Obviously, introduction of ethoxyl groups onto the benzene ring as an electron-donating group facilitates the Zn-induced in situ dimerization of HL1 into new ligand L1′ with a twisted molecular structure, further resulting in a red shift of the fluorescence spectra.

The enhanced catalytic performance of cobalt catalysts towards butadiene polymerization by introducing a labile donor in a salen ligand

A family of cobalt complexes supported by a tridentate Schiff base ligand with a labile donor (O, S, N) as a pendant arm (Co1-Co12, formulated as CoL 2) were synthesized by the treatment of the corresponding ligands with cobalt acetate tetrahyd

Monomeric complexes of Re(CO)3+ ion with tridentate N∩N∩O-ligands - Schiff base derivatives of salicylic aldehyde

Simple synthetic procedures, reactions of Re(CO)5Cl with potentially tridentate N∩N∩OH ligands (Schiff bases prepared from aliphatic or aromatic amines and salicylic aldehyde) lead to formation of monomeric complexes of fac-Re(CO)3s

Two multidentate ligands utilizing triazolyl, pyridinyl and phenolate groups as donors for constructing dinuclear copper(II) and iron(III) complexes: Syntheses, structures, and electrochemistry

Two multidentate ligands 2,2′-(1,1′-(pyridine-2,6-diylbis(methylene))bis(1H-1,2,3-triazole-4,1-diyl))bis(methylene)bis((pyridin-2-ylmethyl)azanediyl)bis(methylene)diphenol (H2LI) and N,N′-((1,1′-(pyridine-2,6-diylbis(methylene))bis(1H-1,2,3-triazole-4,1-diyl))bis(methylene))bis(1-(pyridin-2-yl)-N-(pyridin-2-ylmethyl)methanamine) (LII) containing triazolyl, phenolate and pyridinyl groups were prepared by click reaction between diazide and terminal alkynes in the presence of catalyst CuI. Both ligands were reacted with Cu2+and Fe3+salts to give three dinuclear complexes [LICu2](BPh4)2·2DMF (1), [LII(DMF)2Cu2](ClO4)4·H2O (2) and [LII(FeCl2)2](PF6)2(3). All complexes were characterized by IR, UV-Vis spectra and element analysis. X-ray analysis revealed that the Cu2+centers in complexes 1 and 2 adopted the distorted trigonal bipyramidal geometry, and the Fe3+center in complex 3 chose an octahedral geometry. In addition, the electrochemistry of complexes 1-3 was investigated.

Encapsulation of the BeII cation: Spectroscopic and computational study

The structures of a series of tetracoordinate beryllium(II) complexes with ligands derived from tertiary-substituted amines have been computationally modeled and their 9Be magnetic shielding values determined using the gauge-including atomic orbital (GIAO) method at the 6-311++g(2d,p) level. A good correlation was observed between calculated 9Be NMR chemical shifts when compared to experimental values in polar protic solvents, less so for the values recorded in polar aprotic solvents. A number of alternative complex structures were modeled, resulting in an improvement in experimental versus computational 9Be NMR chemical shifts, suggesting that in some cases full encapsulation on the beryllium atom was not occurring. Several of the synthesized complexes gave rise to unexpected fluorescence, and inspection of the calculated molecular orbital diagrams associated with the electronic transitions suggested that the rigidity imparted by the locking of certain conformations upon BeII coordination allowed delocalization across adjacent aligned aromatic rings bridged by BeII.

Trans-keto* form detection in non photochromic N-salicylidene aminomethylpyridines

Five N-(5-chloro)salicylidene aminomethylpyridine derivatives were successfully synthesized and their structural and solid state optical properties analyzed. Yellow crystalline powders of CH2L3 and CH 2L3-4Cl pr

COMPOUNDS FOR PHOTODYNAMIC THERAPY

A metal-ligand complex comprising a transition metal complexed with at least one Schiff base ligand comprising an additional nitrogen atom from a heterocycle and at least one heteroaromatic nucleic acid intercalating moiety. A pharmaceutical composition c