29096-99-9

Basic information

• Product Name: methyl 2-cyano-3-ethoxyacrylate
• Synonyms: methyl 2-cyano-3-ethoxyacrylate;2-Cyano-3-ethoxyacrylic acid methyl ester;2-Cyano-3-ethoxypropenoic acid methyl ester;Nsc522188;(E)-Methyl 2-cyano-3-ethoxyacrylate;Methyl 2-(ethoxymethylene)-2-cyanoacetate;Methyl cyano(ethoxymethylene)acetate;Methyl cyano(ethoxymethylidene)acetate
• CAS NO: 29096-99-9
• Molecular Formula: C7H9NO3
• Molecular Weight: 155.15126
• EINECS: 249-432-3
• Mol File: 29096-99-9.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 99℃ (0.3 Torr)
• Flash Point: 116.9 °C
• Appearance: /
• Density: 1.102 g/cm³
• Vapor Pressure: 0.00591mmHg at 25°C
• Refractive Index: 1.449
• CAS DataBase Reference: methyl 2-cyano-3-ethoxyacrylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-cyano-3-ethoxyacrylate(29096-99-9)
• EPA Substance Registry System: methyl 2-cyano-3-ethoxyacrylate(29096-99-9)

Safety Data

• Hazardous Substances Data: 29096-99-9(Hazardous Substances Data)

Usage

General Description

Methyl 2-cyano-3-ethoxyacrylate is a chemical compound with the molecular formula C7H9NO3. It is an ethyl ester derivative of cyanoacrylic acid and is commonly used as a monomer in the synthesis of polymers and copolymers. This chemical is known for its excellent adhesion and water resistance, making it a popular choice in adhesives, coatings, and sealants. Methyl 2-cyano-3-ethoxyacrylate is also used in the manufacturing of optical films, electronics, and medical devices due to its high optical clarity and biocompatibility. However, it is important to handle this chemical with caution, as it is flammable and may cause irritation if inhaled or in contact with skin.

InChI:InChI=1/C7H9NO3/c1-3-11-5-6(4-8)7(9)10-2/h5H,3H2,1-2H3/b6-5-

Upstream product

• 74731-49-0 1-(β-hydroxyethyl)-1,2,3-triazole-4-carboxylic acid 
• 141-43-5 ethanolamine 
• 1517-05-1 2-azidoethanol 
• 74-86-2 acetylene 
• 288-36-8 1,2,3-triazole 
• 141072-57-3 1-bromoethanol 
• 122-51-0 orthoformic acid triethyl ester 
• 105-34-0 methyl 2-cyanoacetate 

Downstream Products

• 1076195-44-2 5-(4-methoxyphenyl)-6-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid methyl ester 
• 333761-74-3 5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid methyl ester 
• 89733-80-2 methyl 5-amino-1-(2,3,5-tri-O-benzyl-α-D-arabinofuranosyl)pyrazole-4-carboxylate 
• 89268-89-3 (Z)-2-Cyano-3-decylamino-acrylic acid methyl ester 
• 89268-88-2 (Z)-2-Cyano-3-octylamino-acrylic acid methyl ester 
• 29097-00-5 5-amino-1H-pyrazole-4-carboxylic acid methyl ester 
• 29097-00-5 3-amino-1H-pyrazole-4-carboxylic acid methyl ester 
• 765943-26-8 9-(4-methoxyphenyl)-6-(1-amino-2-cyano-2-methoxycarbonylvinyl)purine 
• 26978-72-3 2-Cyan-3-(N-methylanilino)propensaeure-methylester 

Relevant articles and documents

[4 + 1] Annulation of in situ generated azoalkenes with amines: A powerful approach to access 1-substituted 1,2,3-triazoles

1-Substituted 1,2,3-triazoles represents ‘privileged’ structural scaffolds of many clinical pharmaceuticals. However, the traditional methods for their preparation mainly rely on thermal [3 + 2] cycloaddition of potentially dangerous acetylene and azides. Here we report a base-mediated [4 + 1] annulation of azoalkenes generated in situ from readily available difluoroacetaldehyde N-tosylhydrazones (DFHZ-Ts) with amines under relatively mild conditions. This azide- and acetylene-free strategy provides facile access to diverse 1-substituted 1,2,3-triazole derivatives in high yield in a regiospecific manner. This transformation has great functional group tolerance and can suit a broad substrate scope. Furthermore, the application of this novel methodology in the gram-scale synthesis of an antibiotic drug PH-027 and in the late-stage derivatization of several bioactive small molecules and clinical drugs demonstrated its generality, practicability and applicability.

Production of azo pigment

PROBLEM TO BE SOLVED: To provide a method for manufacturing an azo pigment, which can manufacture the azo pigment having a specific chemical structure in a high efficiency; and to provide an azo pigment manufactured by the same. SOLUTION: The azo pigment represented by formula (2) is manufactured using an acid salt of an amine represented by formula (1). In the formula (2), R1and R2are each independently a hydrogen atom or a substituent. COPYRIGHT: (C)2012,JPOandINPIT

ALPHA-UNSUBSTITUTED ARYLMETHYL PIPERAZINE PYRAZOLO[1,5-A] PYRIMIDINE AMIDE DERIVATIVES

Methods of preventing, treating or delaying the onset of HIV in a subject by administering to the subject novel pharmaceutically active arylmethyl pyrazolo[1,5-α ]pyrimidine amide derivatives, or pharmaceutical compositions containing the same are described. Additionally, compounds of novel pharmaceutically active arylmethyl piperazine pyrazolo[l,5-α]pyrimidine amide derivatives and their use for the manufacture of specific medicaments are described.