2910-79-4Relevant academic research and scientific papers
Novel 4,5-dihydro-1H-pyrazole derivatives as potential succinate dehydrogenase inhibitors: design, synthesis, crystal structure, biological activity and molecular modeling
Cheng, Wei,Jiang, Wenjing,Liu, Hui,Lu, Tong,Tang, Xiaorong,Wang, Jingwen,Xiao, Tingting,Zhang, Guilan,Zhang, Tingting
, (2021/10/05)
Twenty-eight new 4, 5-dihydro-1H-pyrazole derivatives were designed, synthesized and characterized by IR, 1H NMR, 13C NMR and HRMS. The crystal structure of compound 2j was characterized by single crystal X-ray diffraction. Their ant
Design, synthesis, and antifungal activity evaluation of novel 2-cyano-5-oxopentanoic acid derivatives as potential succinate dehydrogenase inhibitors
Mai, Yong-zhan,Peng, Mi-jun,Tang, Xiao-rong,Wang, Xue-song
, p. 94 - 107 (2021/11/22)
Two series of novel 2-cyano-5-oxopentanoic acid derivatives (1a?l, 2a?l) were designed, synthesized, and characterized by IR, 1H NMR, 13C NMR, and HRMS. Their in vitro antifungal activity against five plant pathogenic fungi were then
Pyrazoline analogs as potential anticancer agents and their apoptosis, molecular docking, MD simulation, DNA binding and antioxidant studies
Rana, Manish,Arif, Rizwan,Khan, Faez Iqbal,Maurya, Vikas,Singh, Raja,Faizan, Md Imam,Yasmeen, Shama,Dar, Sajad Hussain,Alam, Raquib,Sahu, Ankita,Ahmad, Tanveer,Rahisuddin
, (2021/02/12)
N-formyl pyrazoline derivatives (3a–3l) were designed and synthesized via Michael addition reaction through cyclization of chalcones with hydrazine hydrate in presence of formic acid. The structural elucidation of N-formyl pyrazoline derivatives was carri
Design, synthesis and insecticidal activity of novel semicarbazones and thiosemicarbazones derived from chalcone
Cheng, Wei,Xiao, Tingting,Qian, Weifeng,Lu, Tong,Zhang, Tingting,Tang, Xiaorong
, p. 3801 - 3809 (2020/03/23)
Thirty semicarbazone and thiosemicarbazone derivatives (2a–w and 4a–g) from chalcones containing furan and thiophene ring were designed and synthesized. They were characterized by IR, 1H NMR, 13C NMR and HRMS. The crystal structure o
Design, synthesis, biological evaluation of 3,5-diaryl-4,5-dihydro-1H-pyrazole carbaldehydes as non-purine xanthine oxidase inhibitors: Tracing the anticancer mechanism via xanthine oxidase inhibition
Joshi, Gaurav,Sharma, Manisha,Kalra, Sourav,Gavande, Navnath S.,Singh, Sandeep,Kumar, Raj
, (2021/01/19)
Xanthine oxidase (XO) has been primarily targeted for the development of anti-hyperuriciemic /anti-gout agents as it catalyzes the conversion of xanthine and hypoxanthine into uric acid. XO overexpression in various cancer is very well correlated due to r
Pyrazoline derivatives as tubulin polymerization inhibitors with one hit for Vascular Endothelial Growth Factor Receptor 2 inhibition
Yang, Bing,Zhou, Jiahua,Wang, Fa,Hu, Xiao-Wei,Shi, Yujun
, (2021/07/13)
In this work, to check the effect of the transposition of the rings in typical patterns, a series of pyrazoline derivatives 3a-3t bearing the characteristic 3,4,5-trimethoxy phenyl and thiophene moieties were synthesized and evaluated as tubulin polymeriz
6-methoxypyridine derivative and application thereof in pesticide
-
Paragraph 0072-0074, (2021/06/22)
The invention relates to a 6-methoxypyridine derivative and application thereof in pesticides, which belong to the technical field of pesticides. The structural formula of the 6-methoxyl pyridine derivative is shown as a formula (I), and in the formula (I
Transition metal-free domino aryl-aryl coupling/phospha-Michael addition of diarylphosphinite to α,β-unsaturated ketones triggered by alkaline hydrolysis of (4-(2-alkenoyl)phenyl)triarylphosphonium salts
Huang, Wenhua,Xue, Jing-Yu
, (2021/11/08)
Alkaline hydrolysis of a variety of (4-(2-alkenoyl)phenyl)triarylphosphonium bromides is reported. This hydrolysis triggers coupling of 4-(2-alkenoyl)phenyl with one aryl via phosphorus(V). Both diarylphosphinite and an α,β-unsaturated ketone are in situ generated and then undergo phospha-Michael addition to provide β-diarylphosphoryl ketones bearing a biaryl moiety in 27–70% yields in the absence of a transition metal.
Donor-acceptor architectures of tetraphenylethene linked aza-BODIPYs: Synthesis, crystal structure, energy transfer and computational studies
Balsukuri, Naresh,Das, Aritra,Gupta, Iti,Lone, Mohsin Y.,Manav, Neha,Mori, Shigeki,Sen, Pratik
, (2020/02/04)
This work is focused on the design and synthesis of donor-acceptor pairs comprising of aza-BODIPY and tetraphenylethene (TPE) fluorogens with large pseudo Stokes shifts (386–424 nm). Femtosecond transient absorption spectroscopy, single crystal X-ray technique and TD-DFT studies were used to get more insight about their spectral behavior. As compared to the tetra-phenylaza-BODIPY, the four aza-BODIPYs exhibited 50–90 nm red shifted absoprtion and emission spectra. When the donor-acceptor architectures were excited at 300 nm, the aza-BODIPY unit emitted strong fluorescence in red region. This suggested an intramolecular energy transfer between donor (TPE) and the aza-BODIPY acceptor; with 81–90% energy transfer efficiencies. Femtosecond transient absorption studies also supported energy transfer process in the molecules, with 3.7 ps time constant associated with it. Aggregation studies in THF/n-heptane solution showed hypsochromic shifts in the aggregated form; X-ray packing structures indicated H-type aggregates (slip angle > 54.7°) in the solid state. Scanning electron microscopy (SEM) measurement revealed 200–700 nm size sphere shaped structures in the aggregated forms.
4, 5-dihydropyrazole compound and application thereof in pesticides
-
Paragraph 0065-0067, (2020/05/14)
The invention relates to a 4, 5-dihydropyrazole compound and an application thereof in pesticides, which belong to the technical field of pesticides. The technical problem to be solved by the invention is to provide a new compound which can be used as an
