2912-78-9

Basic information

• Product Name: 2-hydroxy-5-nitrobenzamide
• Synonyms: 2-hydroxy-5-nitrobenzamide
• CAS NO: 2912-78-9
• Molecular Formula: C₇H₆N₂O₄
• Molecular Weight: 182.134
• Mol File: 2912-78-9.mol

Chemical Properties

• Boiling Point: 357.6°C at 760 mmHg
• Flash Point: 170.1°C
• Appearance: /
• Density: 1.538g/cm³
• Vapor Pressure: 1.31E-05mmHg at 25°C
• Refractive Index: 1.658
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 2-hydroxy-5-nitrobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-5-nitrobenzamide(2912-78-9)
• EPA Substance Registry System: 2-hydroxy-5-nitrobenzamide(2912-78-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 2912-78-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Hydroxy-5-nitrobenzamide is used as an intermediate in the synthesis of salicylamides and its nitro derivatives. These compounds have potential applications in the development of new drugs, particularly those targeting pain relief and inflammation. The presence of the hydroxyl and nitro groups in the molecule allows for further chemical modifications, enabling the creation of a diverse range of pharmaceutically active compounds.
Used in Chemical Synthesis:
In the field of organic chemistry, 2-hydroxy-5-nitrobenzamide serves as a versatile building block for the synthesis of various complex organic molecules. Its unique structural features, including the hydroxyl and nitro groups, make it a valuable precursor for the development of novel chemical entities with potential applications in various industries, such as materials science, agrochemicals, and pharmaceuticals.

InChI:InChI=1/C7H6N2O4/c8-7(11)5-3-4(9(12)13)1-2-6(5)10/h1-3,10H,(H2,8,11)

Upstream product

• 42348-40-3 ethyl 5-nitrosalicylate 
• 7664-41-7 ammonia 
• 97-51-8 5-Nitrosalicylaldehyde 
• 1450-76-6 1-(2-hydroxy-5-nitrophenyl)ethanone 
• 113186-97-3 2-aminomethyl-4-nitro-phenol; hydrochloride 
• 96-97-9 5-nitrosalicylic acid 
• 2674-50-2 N-(2,2,2-trichloro-1-hydroxy-ethyl)-salicylamide 
• 7697-37-2 nitric acid 

Downstream Products

• 38370-02-4 N-(4-Methoxy-benzoyl)-5-nitro-salicylsaeureamid 
• 117821-47-3 2-(Cyclohex-2-enyloxy)-5-nitro-benzamide 

Relevant articles and documents

Acid Catalyzed Direct-Amidation-Dehydrocyclization of 2-Hydroxy-acetophenones to Benzoxazoles by a One-Pot Sustainable Synthesis

A series of 2-methyl-benzoxazoles have been synthesized starting from 2-hydroxy-acetophenones via a one-pot three steps reaction. Hydroxylamonium salt has been used as amidation agent. The reaction occurs with different anions, but the best results is achieved with hydroxylamonium hydrchloride. Despite the number of consecutive stages, the reaction is highly selective. Mild reaction conditions and various solvents can be used, but trifluoroacetic acid is the preferred. Almost, complete recovery of the trifluoroacetic acid can be achieved by vacuum distillation. The role of trifluoroacetic acid, as well as, of the hydroxylamonium salt suggests a cooperative effect leading to high selective formation of 2-methyl-benzoxazoles. Graphical Abstract: One-pot TFA catalyzed synthesis of benzoxazoles starting from 2-hydroxyacetophenones. (Chemical Equation Presented).

High-temperature synthesis of amides from alcohols or aldehydes by using flow chemistry

An efficient conversion of aliphatic and aromatic alcohols or aldehydes into the corresponding primary amides was successfully achieved by using flow chemistry. Excellent yields were obtained in very short reaction times, and thus this method offers an efficient alternative to traditional methods for amide formation.

Antibodies which catalyze hydrolysis of ester bonds

An analog-ligand having a conformation that substantially corresponds to the conformation of a hydrolytic transition state of an amide or ester reactant ligand is used to produce receptor molecules of predetermined specificity. The receptor molecules include an antibody combining site that binds to a reactant ligand and thereby stabilizes the tetrahedral carbon atom of the amide or ester hydrolysis transition state of that reactant ligand to catalytically hydrolyze the reactant ligand at a predetermined site.