42348-40-3

Upstream product

• 118-61-6 2-hydroxy-benzoic acid ethyl ester 
• 72078-81-0 3,5-dinitro-1-(4-nitro-benzyloxy)-1H-pyridin-2-one 
• 1007476-32-5 sodium ethyl acetylacetate enolate 
• 14150-94-8 3,5-dinitro-1-methyl-2-pyridone 
• 141-97-9 ethyl acetoacetate 
• 181294-58-6 N-tert-butyl-β-formyl-β-nitroenamine 
• 618-98-4 ethyl 3-nitrobenzoate 
• 96-97-9 5-nitrosalicylic acid 
• 3094-08-4 5-Nitro-2-ethoxy-benzotrifluorid 
• 69-72-7 salicylic acid 
• 75-03-6 ethyl iodide 

Downstream Products

• 86840-93-9 N-n-Butyl-N'-(2-hydroxy-5-nitrobenzoyl)-diaminoethan-1,2 
• 86840-94-0 N-n-Octyl-N'-(2-hydroxy-5-nitrobenzoyl)-diaminoethan-1,2 
• 2912-78-9 2-hydroxy-5-nitrobenzamide 
• 86840-86-0 1-n-Butyl-2-(2-hydroxy-5-nitrophenyl)-Δ²-imidazolin 
• 84354-91-6 1-n-Octyl-2-(2-hydroxy-5-nitrophenyl)-Δ²-imidazolin 
• 84389-22-0 1-n-Dodecyl-2-(2-hydroxy-5-nitrophenyl)-Δ²-imidazolin 
• 96-97-9 5-nitrosalicylic acid 
• 155388-71-9 benzyl 2-hydroxy-5-nitrobenzoate 
• 874523-84-9 2-benzyloxy-5-nitrobenzoic acid 
• 90484-96-1 '2-<4-Nitro-2-carboxy-phenoxy>-essigsaeure-dihydrazid' 
• 95296-16-5 2-<4-Nitro-2-ethoxycarbonyl-phenoxy>-essigsaeure-hydrazid 
• 99996-88-0 4-Dimethylamino-benzaldehyd-(N-<2-(4-nitro-2-aethoxycarbonyl-phenoxy)-acetyl>-hydrazon) 
• 337520-12-4 4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3-ethoxycarbonylnitrobenzene 
• 855749-73-4 2-benzyloxy-5-nitro-benzoic acid ethyl ester 

Relevant academic research and scientific papers

Photocatalytic Selective Reduction by TiO2 of 5-Nitrosalicylic Acid Ethyl Ester: A Mild Route to Mesalazine

Abstract: Photoexcited TiO2 dispersed in a de-aerated acetonitrile/2-propanol (CH3CN/2-PrOH) reaction mixture catalyzes the quick and selective reduction of 5-nitrosalicylic acid methyl ester to the corresponding aniline, an immediat

Ruthenium(II)-catalyzed synthesis of hydroxylated arenes with ester as an effective directing group

An unprecedented Ru(II) catalyzed ortho-hydroxylation has been developed for the facile synthesis of a variety of multifunctionalized arenes from easily accessible ethyl benzoates with ester as an efficient directing group. Both the TFA/TFAA cosolvent system and oxidants serve as the critical success factors in this transformation. The reaction demonstrates excellent reactivity, good functional group tolerance, and high yields.

A convenient method for synthesizing modified 4-nitrophenols

β-Nitroenamine having a formyl group behaves as the synthetic equivalent of unstable nitromalonaldehyde upon treatment with ketones under basic conditions and leads to 2,6-disubstituted 4-nitrophenols. The present method is safer than the conventional one using sodium nitromalonaldehyde and enables the preparation of hitherto unknown nitrophenols.

BENZAMIDINE DERIVATIVES

Benzamidine derivatives of formula (I) or pharmaceutically acceptable salts thereof exhibit excellent inhibitory activity against factor Xa and are useful for treating or preventing blood coagulation disorders: wherein R 1represents a hydrogen atom, a halogen atom, an alkyl group or a hydroxyl group; R 2represents a hydrogen atom, a halogen atom or an alkyl group, R 3represents a hydrogen atom, an optionally substituted alkyl group, an aralkyl group, an optionally substituted alkanoyl group or an optionally substituted alkylsulfonyl group, R 4and R 5 are the same as or different from each other and each represent a hydrogen atom, a halogen atom, an optionally substituted alkyl group, an alkoxy group, a carboxyl group, an alkoxycarbonyl group or an optionally substituted carbamoyl group, and R 6represents a substituted pyrrolidine group or substituted piperidine group.

Benzoxazepinones and their use as squalene synthase inhibitors

There is disclosed a compound represented by the formula [I]: wherein R1 is optionally substituted 1-carboxyethyl group, optionally substituted alkyl-sulfonyl group, optionally substituted (carboxy-cycloalkyl)-alkyl group, -X1-X2-Ar-X3-X4-COOH (wherein X1 and X4 are a bond or alkylene group, X2 and X3 are a bond, -O-, -S-, Ar is divalent aromatic group etc.), R2 is alkyl group optionally substituted with alkanoyloxy group and/or hydroxy group, R3 is alkyl group, and W is halogen atom, etc., or a salt thereof. The compound has the cholesterol lowering activity and the triglyceride lowering activity and is useful for preventing and/or treating hyperlipidemia.

BIPHENYL DERIVATIVES

A biphenyl derivative represented by the following formula (I) or a pharmacologically acceptable salt thereof: STR1 wherein R 1, R. sup.2, R 3, R 4, and R 5 are defined in the specification, is clinically useful for treating and ameliorating mental disorders such as cerebrovascular disorder, aggressive behavior due to senile dementia, mental excitation, poriomania, delirium, hallucination, hyperkinesia, schizophrenia, emotional disturbance, depression, neurosis, psychophysiologic disorder and anxiety neurosis. The compounds exhibit dopamine 2 receptor antagonism and/or serotonin 2 receptor antagonism.

Nucleophilic Reaction upon Electron-deficient Pyridone Derivatives. IV. Ring Transformation of 1-Substituted 3,5-Dinitro-2-pyridones with Ketones in the Presence of Amines

Ring transformation of 1-substituted 3,5-dinitro-2-pyridones with 1,3-disubstituted acetones in the presence of secondary or primary amines gave p-nitroaniline derivatives and N-substituted 2-nitroacetamide.Two types of enamine intermediates, 2-azabicyclononene derivatives and N-substituted 2-(5-amino-2-nitro-2,4-cyclohexadienyl)-2-nitroacetamides were isolated and characterized.The course of the base-catalyzed reaction is interpreted.