111836-35-2

Upstream product

• 81167-39-7 methyl N-(diphenylmethylene)glycinate 
• 768-03-6 Phenyl vinyl ketone 
• 71460-02-1 methyl 2-[((1,1-dimethylethoxy)carbonyl)amino]-4-pentynoate 
• 291534-50-4 (+/-)-methyl 2-(tert-butoxycarbonylamino)-5-phenylpent-4-ynoate 
• 66646-88-6 methyl 2-(benzylideneamino)acetate 
• 2847-91-8 4-acetamido-4,4-diethoxycarbonyl-1-phenylbutan-1-one 
• 29636-75-7 3-bromo-1-phenylpropan-1-one 
• 1501-04-8 Methyl 4-benzoylbutanoate 
• 934520-52-2 5-hydroxyimino-5-phenylpentanoic acid methyl ester 
• 67-56-1 methanol 
• 2847-90-7 5-Phenyl-3,4-dihydro-2H-pyrrole-2-carboxylic acid; hydrochloride 
• 111836-48-7 4-(2-Phenyl-[1,3]dioxolan-2-yl)-2-{[1-phenyl-meth-(E)-ylidene]-amino}-butyric acid methyl ester 

Downstream Products

• 111836-43-2 2-[(2-Methoxycarbonyl-5-phenyl-3,4-dihydro-2H-pyrrol-2-yl)-phenyl-methyl]-malonic acid dimethyl ester 
• 111836-43-2 2-[(R)-((R)-2-Methoxycarbonyl-5-phenyl-3,4-dihydro-2H-pyrrol-2-yl)-phenyl-methyl]-malonic acid dimethyl ester 

Relevant academic research and scientific papers

Enantioselective Copper-Catalyzed Electrophilic Sulfenylation of Cyclic Imino Esters

Herein we report an enantioselective sulfenylation of cyclic imino esters with the efficient and versatile sulfenylation reagent S-alkyl 4-methylbenzenesulfonothioates. By utilizing the Cu/tBu-Phosferrox catalytic system, we can assemble diverse S-alkyl groups into the cyclic imino esters under mild conditions in good yields and with excellent enantioselectivities. Remarkably, this method demonstrates a high tolerance of diverse functional groups and proves to be applicable in the late-stage functionalization of pharmaceuticals.

Stereoselective Allylic Alkylation of 1-Pyrroline-5-carboxylic Esters via a Pd/Cu Dual Catalysis

The asymmetric allylation of 1-pyrroline-5-carboxylic esters has been accomplished through a synergistic Pd/Cu catalyst system under mild reaction conditions. The mechanistic studies suggested that (1) nucleophilic attack is the enantiodiscriminating step; (2) the cooperative action of two chiral reactive species, N-metalated azomethine ylides and ?€-allylpalladium, is most likely responsible for its high reactivity and excellent enantioselectivity (up to >99% ee); and (3) the steric hindrance and electronic factors of the allylic electrophiles and imino ester substrates are crucial for the formation of the linear products. A series of 3,4-2H-pyrrole derivatives bearing a quaternary stereogenic center were easily synthesized in high yields and with high to excellent regioselectivity and enantioselectivity.

Gold-Catalyzed Cycloisomerization of Alkyne-Containing Amino Acids: Controlled Tuning of C–N vs. C–O Reactivity

Versatile alkyne-containing amino acids were used as ambident precursors in the divergent synthesis of alkylidenelactones and 1-pyrrolines. Two gold-catalyzed protocols were applied for selective intramolecular O- and N-cycloisomerization reactions.

Novel intramolecular reactivity of oximes: Synthesis of cyclic and spiro-fused imines

(Chemical Equation Presented) Under conventional heat (135-145°C) or microwave irradiation and 1 equiv of acetic anhydride, ortho-substituted aryl-oximes undergo a novel sp3 C-H activated cyclization to produce the corresponding isoindoles, and

Double diastereoselectivite de la cycloaddition dipolaire-1,3 d'ylures d'azomethine cycliques substitues

Seven derivatives of methyl 5-phenyl-3,4-dihydro-2H-pyrrole-2-carboxylates 1 were synthesized.These compounds are precursors of pentagonal cyclic azomethine ylides, the two sides of which are diastereotopic.The 1,3-dipolar species react with N-methyl and

SYNTHESIS OF α-ACTIVATED Δ1 PYRROLINE AND Δ1 PIPERIDEINE: 1,3 DIPOLAR AND ANIONIC REACTIVITIES.

The α-activated Δ1 pyrroline 4 and Δ1 piperideine 5 are synthesized.By thermal reaction with alkenes they give 1,3 dipolar cycloadducts and their anions lead to alkylation products.