29193-63-3

Usage

InChI:InChI=1/C10H11ClO2S/c11-8-3-5-9(6-4-8)14-7-1-2-10(12)13/h3-6H,1-2,7H2,(H,12,13)

Upstream product

• 96-48-0 4-butanolide 
• 106-54-7 p-Chlorothiophenol 
• 1142-19-4 4,4'-dichlorodiphenyl disulfide 
• 29107-85-5 ethyl 4-((4-chlorophenyl)thio)butanoate 
• 2623-87-2 bromobutyric acid 
• 18803-44-6 sodium p-chlorothiophenolate 

Downstream Products

• 61797-42-0 4-(4-Chloro-phenylsulfanyl)-N-(2-{[4-(4-chloro-phenylsulfanyl)-butyryl]-methyl-amino}-ethyl)-N-methyl-butyramide 
• 61016-63-5 Sodium 4-(p-Chlorophenylthio)butyrate 
• 30484-10-7 7-Chloro-2,3,4,5-tetrahydro-1-benzothiepin-5-one 
• 114302-74-8 Carboxydimethylmethyl--sulfoxid 
• 29193-68-8 4-<4-Chlor-benzolsulfonyl>-buttersaeure 

Relevant academic research and scientific papers

Production of Alkyl Aryl Sulfides from Aromatic Disulfides and Alkyl Carboxylates via a Disilathiane–Disulfide Interchange Reaction

The results of this study show that disilathiane is an effective mediator in the synthesis of alkyl aryl sulfides with disulfides and alkyl carboxylates. Mechanistic studies suggest that disilathiane promotes cleavage of the sulfur–sulfur bond of disulfides to generate thiosilane as a key intermediate. Diselenides were also applicable to this transformation to produce the corresponding selenides.

Design, synthesis, and biological evaluation of 3-amino-2-oxazolidinone derivatives as potent quorum-sensing inhibitors of Pseudomonas aeruginosa PAO1

Due to the increasing resistance of Pseudomonas aeruginosa to most clinically relevant antimicrobials, it is challenging to treat bacterial infection with traditional antibiotics. Quorum sensing can regulate the production of biofilms and virulence factors which are closely related to bacterial resistance. Previously we synthesized a series of oxazolidinone compounds targeting the quorum-sensing transcriptional regulatory protein CviR and ZS-12 showed good activity against Chromobacterium violaceum CV026 quorum-sensing. In this study, eighteen 3-amino-2-oxazolidinone compounds were designed and synthesized using ZS-12 as the lead compound. We initially evaluated the inhibitory activities of novel oxazolidinone compounds against QS using C. violaceum CV026 as a reporter strain. Thirteen compounds showed good activities (IC50 range 3.69–63.58 μM) and YXL-13 inhibition was the most significant (IC50 = 3.686 ± 0.5790 μM) against biofilm formation and virulence factors determination of P. aeruginosa PAO1. In vitro, YXL-13 significantly inhibited the formation of PAO1 biofilm (range 42.98%–17.67%), the production of virulence factors (pyocyanin, elastase, rhamnolipid, and protease), and bacterial motility. Moreover, the combination of YXL-13 with an antibiotic (meropenem trihydrate) could significantly improve the antibiotic susceptibility of biofilm P. aeruginosa PAO1 cells. In vivo, YXL-13 significantly prolonged the lifespan of wildtype Caenorhabditis elegans N2 infected by P. aeruginosa PAO1. In conclusion, YXL-13 is a candidate agent for antibiotic-resistant P. aeruginosa PAO1and provides a method for finding new antibacterial drugs.

Thiochroman-4-one thiosemicarbazide compound as well as preparation method and application thereof

The invention relates to a thiochroman-4-one thiosemicarbazide compound, as well as a preparation method and an application thereof. The structural formula of the thiochroman-4-one thiosemicarbazide compound is shown as Formula (I), wherein n is 1 or 2, R

ARYLSULFANYL COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS

Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are also provided.