29198-43-4

Usage

Uses

Used in Pharmaceutical Industry:
2-Benzothiazolecarboxamide is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Benzothiazolecarboxamide serves as an intermediate, playing a role in the creation of compounds that can be used in the development of pesticides and other agricultural chemicals to protect crops and enhance yields.
Used in Dye Industry:
2-Benzothiazolecarboxamide is utilized as an intermediate in the synthesis of dyes, contributing to the production of a variety of colorants used in different industries, such as textiles, plastics, and printing inks.
Used as a Corrosion Inhibitor:
2-Benzothiazolecarboxamide(6CI,8CI,9CI) functions as a corrosion inhibitor, helping to protect materials from degradation and extending their service life in various industrial applications.
Used as an Antiviral and Antifungal Agent:
2-Benzothiazolecarboxamide exhibits antiviral and antifungal properties, making it useful in the development of treatments and preventative measures against viral and fungal infections.

Upstream product

• 90345-46-3 2-(phenylamino)-2-thiooxoacetamide 
• 95-16-9 1,3-Benzothiazole 
• 77287-34-4 formamide 
• 32137-76-1 benzothiazole-2-carboxylic acid ethyl ester 
• 31767-14-3 ethyl 2-(hydroxyimino)acetate 
• 137-07-5 2-amino-benzenethiol 
• 37693-82-6 10H-benzo[b]pyrazino[2,3-e][1,4]thiazine 
• 816-27-3 ethyl 2-ethoxy-2-iminoacetate 
• 17270-94-9 N-Phenyldithiooxamide 
• 10543-64-3 phenyl-oxalamide 
• 125244-74-8 oxanilic acid thioamide 
• 4955-82-2 1-cyanothioformanilide 
• 120-75-2 2-Methylbenzothiazole 
• 56278-50-3 2-cyanomethylbenzothiazole 

Downstream Products

• 64377-94-2 benzo[d]thiazole-2-carbothioamide 
• 121779-90-6 Benzothiazole-2-carboxylic acid [3-phenyl-thiazolidin-(2Z)-ylidene]-amide 
• 188672-83-5 6-nitro-1,3-benzothiazole-2-carbonitrile 
• 7724-12-1 2-cyano-6-aminobenzothiazole 
• 63677-22-5 2-(4-phenyl-thiazol-2-yl)-benzothiazole 
• 64377-97-5 2-[4-(4-bromo-phenyl)-thiazol-2-yl]-benzothiazole 

Relevant academic research and scientific papers

Slow magnetization dynamics in a six-coordinate Fe(ii)-radical complex

A new paramagnetic ligand, betaDTDA, and its coordination complex with Fe(hfac)2 are reported (betaDTDA = 4-(benzothiazol-2′-yl)-1,2,3,5-dithiadiazolyl; hfac = 1,1,1,5,5,5-hexafluoroacetylacetonato-). The neutral radical betaDTDA is the first dithiadiazolyl ligand designed to include an electropositive sulphur moiety outside the thiazyl heterocycle, increasing the capacity for supramolecular, structure-directing electrostatic contacts and enabling new pathways for magnetic exchange. The Fe(hfac)2(betaDTDA) complex is composed of a hs-Fe(ii) center with the three bidentate ligands arranged about the ion in a distorted octahedral 6-coordinate environment. The magnetic properties of crystalline Fe(hfac)2(betaDTDA) are consistent with strong antiferromagnetic (AF) coupling between the metal and ligand moments, giving rise to a well-defined Stotal = 3/2 ground state that is the only thermally populated state below 40 K. Below 4 K, this complex exhibits slow relaxation of the magnetization detected by ac susceptibility measurements consistent with a single-molecule magnet (SMM) behaviour.

Direct Oxidative Amination of the Methyl C-H Bond in N-Heterocycles over Metal-Free Mesoporous Carbon

Direct oxidative amination of the sp3C-H bond is an attractive synthesis route to obtain amides. Conventional catalytic systems for this transformation are based on transition metals and complicated synthesis processes. Herein, direct and efficient oxidative amination of the methyl C-H bond in a wide range of N-heterocycles to access the corresponding amides over metal-free porous carbon is successfully developed. To understand the fundamental structure-activity relationships of carbon catalysts, the surface functional groups and the graphitization degree of porous carbon have been purposefully tailored through doping with nitrogen or phosphorus. The results of characterization, kinetic studies, liquid-phase adsorption experiments, and theoretical calculations indicate that the high activity of the carbon catalyst is attributed to the synergistic effect of surface acidic functional groups (hydroxyl/carboxylic acid/phosphate) and more graphene edge structures exposed on the surface of carbon materials with a high graphitization degree, in which the role of acidic functional groups is to adsorb the substrate molecule and the role of the graphene edge structure is to activate O2

On the design of new europium heteroaromatic carboxylates for OLED application

The approach to the directed synthesis of lanthanide aromatic carboxylates – precursors to the electroluminescent materials, - was proposed, namely the conjugation length increase and heteroatom introduction in the appropriate position in combination with

Ruthenium-catalyzed oxidative decyanative cross-coupling of acetonitriles with amines in air: A general access to primary to tertiary amides under mild conditions

Catalyzed by Ru and in the presence of air and nucleophiles such as amines or ammonia, activation of the C-CN bond could be easily achieved under mild conditions to produce primary to tertiary amides in good to excellent yields. The use of accessible and functional-group-tolerant starting materials, a cheap, low-loading and recyclable catalyst, ligand-free conditions and excellent product yields are the advantages of the method. Moreover, compared with the Ritter reaction and hydration methods, this novel reaction has more comprehensive application scope.

A method for synthesis of amides

The invention discloses a synthesizing method for an amide compound shown in formula (III). The synthesizing method comprises the following steps: adopting replacing acetonitrile shown in formula (I) and amines compound shown in formula (II) as raw materials in air atmosphere; adopting Ru/C as a catalyst; conducting reaction in solvent to generate the amide compound shown in formula (III); the solvent is one selected from ethyl alcohol, furanidine, methyl sulfoxide and o-dichlorobenzene. The synthesizing method being novel synthesizing route is simple to operate, convenient in post-treatment, high in product yield, and good in product purity; particularly, the catalyst and the solvent can be used repeatedly; air is taken as oxidant; not only production cost is reduced, but also the method is environmental-friendly, and very suitable for large-scale industrialization production.

Copper catalysed direct amidation of methyl groups with N-H bonds

An efficient copper catalyzed direct aerobic oxidative amidation of methyl groups of azaarylmethanes with N-H bonds producing amides is successfully developed, which can produce primary, secondary and tertiary amides, including those with functional groups. This reaction represents a straightforward method for the preparation of amides from the readily available hydrocarbon starting materials.

Hydroxylamine as an oxygen nucleophile: Substitution of sulfonamide by a hydroxyl group in benzothiazole-2-sulfonamides

Benzothiazole-2-sulfonamides react with an excess of hydroxylamine in aqueous solutions to form 2-hydroxybenzothiazole, sulfur dioxide, and the corresponding amine. Mechanistic studies that employ a combination of structure-reactivity relationships, oxygen labeling experiments, and (in)direct detection of intermediates and products reveal that the reaction proceeds via oxygen attack, and that oxygen incorporated in the 2-hydroxybenzothiazole product derives from hydroxylamine. The reaction, which is performed under mild conditions, can be used as a deprotection method for cleavage of benzothiazole-2-sulfonyl-protected amino acids.

METHODS AND SYSTEMS FOR SYNTHESIS OF A D-AMINOLUCIFERIN PRECURSOR AND RELATED COMPOUNDS

Methods and systems to generate 6-amino-6-deoxy-D-luciferin precursor, 2-cyano-6-aminobenzothiazole and related compounds and derivatives

METHODS AND SYSTEMS FOR SYNTHESIS OF A D-AMINOLUCIFERIN PRECURSOR AND RELATED COMPOUNDS

Methods and systems to generate 6-amino-6-deoxy-D-luciferin precursor, 2-cyano-6-aminobenzothiazole and related compounds and derivatives

The Reaction Between 2-Aminobenzenethiol and Diethyl Oxalate. A Structural Reassegnement

It is proposed that the reported condensation between 2-aminobenzenethiol and diethyloxalate give rise to 2-ethoxycarbonylbenzothiazole 3 rather than 3-ethoxy-2H-1,4-benzothiazin-2-one 2.