29202-08-2

Upstream product

• 1121-60-4 pyridine-2-carbaldehyde 
• 106-40-1 4-bromo-aniline 
• 7471-13-8 N-(pyrid-2-ylmethylene)-p-tolylamine 

Downstream Products

• 1240303-40-5 dichloro((4-bromophenyl)pyridin-2-ylmethyleneamine)platinum(II) 
• 1403825-51-3 [Re(CO)3Br((4-bromophenyl)pyridin-2-ylmethyleneamine)] 
• 7471-13-8 N-(pyrid-2-ylmethylene)-p-tolylamine 
• 1160974-74-2 [Hg₂((4-bromophenyl)pyridin-2-ylmethyleneamine)2](NO₃)2 

Relevant academic research and scientific papers

Five-coordinate dinuclar cobalt (II), copper (II), zinc (II) and cadmium (II) complexes with 4-bromo-N-(2-pyridinylmethylene)benzenamine: Synthesis, characterisation and methyl methacrylate polymerization

A series of late transition metal complexes, [(bpma)Co(μ–Cl)Cl]2, [(bpma)Cu(μ–Cl)Cl]2, [(bpma)Zn(μ–Cl)Cl]2 and [(bpma)Cd(μ–Br)Br]2 (where bpma is 4-bromo-N-((pyridin-2-yl)methylene)benzenamine) have been synthes

Synthesis, characterization, and antimicrobial studies of half-sandwich η6-toluene ruthenium complexes with N,N′-bidentate ligands

Nine new complexes [(η6-C6H5-CH3)RuLCl]+(PF6)ˉ (where L = N,N′-bidentate ligand; (C5H4NCH = N-Ar) where Ar = 4-methylphenyl (C20H20ClF6N2PRu, 1); 3,4-dimethylphenyl (C21H22ClF6N2PRu, 2); 2,4,6-trimethylphenyl (C21H24ClF6N2PRu, 3); 4-bromophenyl (C19H17ClBrF6N2PRu, 4); 2,5-dimethylphenyl (C21H22ClF6N2PRu, 5); 2-flourophenyl (C19H17ClF7N2PRu, 6), (4-methoxyphenyl)methylene (C21H22ClF6N2OPRu, 7); phenylmethylene (C20H20ClF6N2PRu, 8); and 3,5-dimethylphenyl (C21H22ClF6N2PRu, 9) were synthesized by reacting the corresponding N,N′-bidentate ligands with the ruthenium arene dimer in a 2:1 ratio. The compounds were fully characterized via 1H NMR and 13C NMR, IR, and UV-vis spectroscopy and elemental analyses. The molecular structures of representative complexes (1, 7, and 8) were established by single-crystal X-ray diffraction studies. In the molecular structures of the complexes, the ligands coordinate to the Ru(II) centers via the pyridine nitrogen atom and the imine N atom in a bidentate manner. The other coordination sites of the Ru(II) center are occupied by the tolyl system in an η6 manner resulting in geometry often referred to as “pseudo-octahedral piano-stool.” All compounds were evaluated for their in?vitro antibacterial activity by the disk diffusion method against a panel of Gram-negative and Gram-positive bacteria. The complexes showed promising bactericidal activity against methicillin-resistant Staphylococcus aureus ATCC 43300.

Quantitative Reactivity Scales for Dynamic Covalent and Systems Chemistry

Dynamic covalent chemistry (DCC) has become a powerful tool for the creation of molecular assemblies and complex systems in chemistry and materials science. Herein we developed for the first time quantitative reactivity scales capable of correlation and prediction of the equilibrium of dynamic covalent reactions (DCRs). The reference reactions are based upon universal DCRs between imines, one of the most utilized structural motifs in DCC, and a series of O-, N-, and S- mononucleophiles. Aromatic imines derived from pyridine-2-carboxyaldehyde exhibit capability for controlling the equilibrium through distinct substituent effects. Electron-donating groups (EDGs) stabilize the imine through quinoidal resonance, while electron-withdrawing groups (EWGs) stabilize the adduct by enhancing intramolecular hydrogen bonding, resulting in curvature in Hammett analysis. Notably, unique nonlinearity induced by both EDGs and EWGs emerged in Hammett plot when cyclic secondary amines were used. This is the first time such a behavior is observed in a thermodynamically controlled system, to the best of our knowledge. Unified quantitative reactivity scales were proposed for DCC and defined by the correlation log K = SN (RN + RE). Nucleophilicity parameters (RN and SN) and electrophilicity parameters (RE) were then developed from DCRs discovered. Furthermore, the predictive power of those parameters was verified by successful correlation of other DCRs, validating our reactivity scales as a general and useful tool for the evaluation and modeling of DCRs. The reactivity parameters proposed here should be complementary to well-established kinetics based parameters and find applications in many aspects, such as DCR discovery, bioconjugation, and catalysis.

Biological properties of heterocyclic pyridinylimines and pyridinylhydrazones

This work describes the synthesis and biological properties of a series of 2- and 4- pyridinylimines and pyridinylhydrazones. All compounds were evaluated in vitro against two species of Leishmania. The antioxidant activity and the toxic effect against mu

Biological properties of heterocyclic pyridinylimines and pyridinylhydrazones

This work describes the synthesis and biological properties of a series of 2- and 4-pyridinylimines and pyridinylhydrazones. All compounds were evaluated in vitro against two species of Leishmania. The antioxidant activity and the toxic effect against mur

Synthesis, crystal structure and conjugation properties of iminopyridine copper(I) phosphine complexes

Some copper(I) complexes with imonopyridine ligands [Cu(L1)(PPh3)2]X (X = Cl (1a), ClO4 (2a), BF4 (3a), PF6 (4a)) and [Cu(L2)(PPh3)2]X (X = Cl (1b), ClO4 (2b), BF4 (3b), PF6 (4b)) [Where L1 = N-(2-pyridylmethylene)-4-(bromo)aniline, L2 = N-(2-pyridylmethylene)-4-(ethynyl)aniline; PPh3 = triphenylphosphine] have been synthesized and characterized on the basis of their elemental analyses, IR, 1H NMR and 31P NMR spectral studies. The representative complexes [Cu(L1)(PPh3)2]ClO4 (2a) and [Cu(L2)(PPh3)2]PF6 (4b) were characterized by single crystal X-ray analysis which reveals a distorted tetrahedral geometry around each copper(I) center. Quasireversible redox behavior is accounted for all complexes corresponding to Cu(II)/Cu(I) couple. Photophysical properties of all complexes indicate that the insertion of ethynyl (CC-H) functionality on iminopyridine induces pronounced red shift in absorption and emission wavelength of copper(I) complexes.

Synthesis of di-nitrogen Schiff base complexes of methyltrioxorhenium(VII) and their application in epoxidation with aqueous hydrogen peroxide as oxidant

Several di-nitrogen Schiff bases were synthesized through the condensation of 2-pyridinecarboxaldehyde with primary amines. The Schiff bases as ligands coordinated with methyltrioxorhenium (MTO) smoothly to afford the correspondent complexes which were characterized by IR, 1H NMR, 13C NMR, MS and elemental analysis. One of the complexes was analyzed by X-ray crystallography as well. The results revealed that the complexes display distorted octahedral geometry in the solid state with a trans-position of Schiff base. Catalytic results indicated that the complexes as catalysts increased the selectivity of epoxides remarkably compared with MTO in the epoxidation of alkenes with 30% hydrogen peroxide as oxidant and the increasing rate depended on the structure of the Schiff base ligands of the complexes. The results indicated that the stronger the donating ability of the ligand, the higher selectivity of epoxides the complex gave in the epoxidation of alkenes with 30% hydrogen peroxide as oxidant. Copyright

Synthesis and electrochemical studies of nickel -diketonate complexes incorporating asymmetric diimine ligands

The reaction of ppaX {(4-X-phenyl)-pyridin-2-ylmethylene-amine; X = H, Me, Et, OMe, F, Cl, Br, and I} with [Ni(β-diketonate) 2(H2O)2] {β-diketonate = 1,3-diphenylpropanedionate (dbm), 2,2,6,6-tetramethyl-3,5-hep

2-pyridine Derivatives: New Antiinflammatory Agents

2-pyridine derivatives (1a-e) inhibited the dermal reverse passive Arthus reaction (RPAR) in the rat.In the same model, indomethacin was inactive, and hydrocortisone was active.Compounds 1a-d also significantly reduced exudate volume and white blood cell accumulation in the pleural RPAR.This pattern of activity was similar to that of hydrocortisone and different from that of indomethacin.