292045-48-8Relevant academic research and scientific papers
Regioselective synthesis of folic acid conjugates from diether-type archaeal lipid analogues
Lainé, Céline,Mocquet, Clémence,Lemiègre, Lo?c,Benvegnu, Thierry
, p. 1455 - 1460 (2009)
A regioselective access to both α- and γ-folic acid conjugates derived from archaeal lipid analogues is described. The synthetic approach is based on conveniently protected glutamates that led first to α- and γ-glutamate derivatives. The final reconstruct
A step-wise synthetic approach is necessary to access γ-conjugates of folate: Folate-conjugated prodigiosenes
Figliola, Carlotta,Marchal, Estelle,Groves, Brandon R.,Thompson, Alison
, p. 14078 - 14092 (2019/05/21)
Despite the vast literature that describes reacting folic acid with a pharmacophore, this route is ineffective in providing the correct regioisomer of the resulting conjugate. We herein present a step-wise route to the preparation of nine folate conjugate
PROCESS FOR PRODUCING FOLIC ACID DERIVATIVE
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Page/Page column 6, (2008/06/13)
This invention provides a process for efficient production of folic acid derivatives suitable for forming conjugates of anticancer drug with folic acid. It discloses a process comprising a step of reacting 2-amino-protected pteroylimidazole with 3-lower a
