292060-57-2Relevant academic research and scientific papers
An unhydrolyzable analogue of N-(4-hydroxyphenyl)retinamide: Synthesis and preliminary biological studies
Weiss, Kevin L.,Alshafie, Galal,Chapman, Jason S.,Mershon, Serena M.,Abou-Issa, Hussein,Clagett-Dame, Margaret,Curley Jr., Robert W.
, p. 1583 - 1586 (2001)
The synthesis of a nonhydrolyzable, carbon-linked analogue (4-HBR) of the retinoid N-(4-hydroxyphenyl)retinamide (4-HPR) using Umpolung methods is described. Preliminary studies of biological activity show 4-HBR is similar to 4-HPR in its actions although a potentially relevant and desirable difference is its reduced suppression of plasma vitamin A levels. These results show that 4-HPR does not have to be hydrolyzed to retinoic acid to produce its chemotherapeutic effects. Elsevier Science Ltd. All rights reserved.
