292067-97-1

Basic information

• Product Name: Etoricoxib impurity Q
• Synonyms: Etoricoxib impurity Q;5-chloro-6'-methyl-3-(4-(methylthio)phenyl)-2,3'-bipyridine
• CAS NO: 292067-97-1
• Molecular Formula: C₁₈H₁₅ClN₂S
• Molecular Weight: 326.8431
• Mol File: 292067-97-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Etoricoxib impurity Q(CAS DataBase Reference)
• NIST Chemistry Reference: Etoricoxib impurity Q(292067-97-1)
• EPA Substance Registry System: Etoricoxib impurity Q(292067-97-1)

Safety Data

• Hazardous Substances Data: 292067-97-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Etoricoxib impurity Q is used as a reference material for quality control and regulatory compliance in the production and processing of etoricoxib. Its presence in the drug substance needs to be minimized to ensure the safety and efficacy of the final drug product, as well as to comply with regulatory standards for pharmaceutical products. Thorough testing and analysis are carried out during the production process to ensure that levels of Etoricoxib impurity Q are kept within acceptable limits.

Upstream product

• 221615-72-1 1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone 
• 745050-30-0 2,5-dichloro-3-[4-(methylthio)phenyl]pyridine 
• 175883-59-7 5-trimethylstannanyl-2-methylpyridine 
• 50704-42-2 2-chloromalonaldehyde 
• 321913-54-6 1-(6-methyl-3-pyridinyl)-2-cyano-2-[(4-methylthio)phenyl]ethanone 
• 5470-70-2 Methyl 6-methylnicotinate 
• 38746-92-8 2-[4-(methylsulfanyl)phenyl]acetonitrile 
• 745050-28-6 2-benzoyloxy-5-chloro-3-[4-(methylthio)phenyl]pyridine 
• 745050-29-7 5-chloro-2-hydroxy-3-[4-(methylthio)phenyl]pyridine 

Downstream Products

• 202409-33-4 etoricoxib 
• 1447814-82-5 5-chloro-3-(4-methylthiophenyl)-6'-methyl-[2,3']bipyridine hydrochloride 
• 866336-08-5 thiobutyric acid S-[4-(5-chloro-6'-methyl-[2,3']bipyridinyl-3-yl)phenyl] ester 

Relevant articles and documents

Selective Late-Stage Oxygenation of Sulfides with Ground-State Oxygen by Uranyl Photocatalysis

Oxygenation is a fundamental transformation in synthesis. Herein, we describe the selective late-stage oxygenation of sulfur-containing complex molecules with ground-state oxygen under ambient conditions. The high oxidation potential of the active uranyl cation (UO22+) enabled the efficient synthesis of sulfones. The ligand-to-metal charge transfer process (LMCT) from O 2p to U 5f within the O=U=O group, which generates a UV center and an oxygen radical, is assumed to be affected by the solvent and additives, and can be tuned to promote selective sulfoxidation. This tunable strategy enabled the batch synthesis of 32 pharmaceuticals and analogues by late-stage oxygenation in an atom- and step-efficient manner.

PROCESS FOR THE SYNTHESIS OF ETORICOXIB

The present invention relates to a process for the synthesis of the anti-inflammatory agent 5-chloro-3-(4-methanesulfonylphenyl)-6'-methyl-[2,3']bipyridine, referred to as compound of formula (1) or etoricoxib, which is a pharmaceutically active ingredient inhibiting cyclooxygenase-2. In particular, the application concerns a novel process of making the compound of formula (1) by oxidizing a compound of formula (4).

PROCESS FOR CYCLOOXYGENASE-2 SELECTIVE INHIBITOR

The present invention describes a process for preparing a cyclooxygenase-2 selective inhibitor. It provides a synthetic procedure for the said substance namely 5-chloro-3-(4-methylsulphonyl)phenyl-2-(2-methyl-5-pyridinyl)pyridine of formula (I). The invention also relates to preparation of a new intermediate of formula (IV) and a process to prepare it. Furthermore, the invention describes a process for preparing another key intermediate of formula (II). Compounds of formula (IV) and formula (II) are useful intermediates in synthesis of the said cyclooxygenase-2 inhibitor.

A PROCESS FOR CYCLOOXYGENASE-2 SELECTIVE INHIBITOR

The present invention describes a process for preparing a cyclooxygenase-2 selective inhibitor. It provides a synthetic procedure for the said substance namely 5-chloro-3-(4-methylsulphonyl) phenyl-2-(2-methyl-5-pyridinyl) pyridine of formula (I). The invention also relates to preparation of a new intermediate of formula (IV) and a process to prepare it. Furthermore, the invention describes a process for preparing another key intermediate of formula (II). Compounds of formula (IV) and formula (II) are useful intermediates in synthesis of the said cyclooxygenase-2 inhibitor.

Racemic and chiral sulfoxides as potential prodrugs of the COX-2 inhibitors Vioxx and Arcoxia

The preparation of the sulfoxide analogues 2 and 4, and their enantiomeric pure forms is discussed as well as their potential to act as prodrugs to the potent and selective sulfone-containing COX-2 inhibitors rofecoxib and etoricoxib. Sulfoxides 2 and 4 w

A general method for the synthesis of aryl [11C]methylsulfones: Potential PET probes for imaging cyclooxygenase-2 expression

A general one-pot method has been developed for the conversion of an aryl thiol moiety masked as the butyrate ester to the corresponding 11C-labeled methylsulfone group. The potential of this methodology has been demonstrated by the successful radiosynthesis of carbon-11 analogues of several highly selective cyclooxygenase-2 (COX-2) inhibitors such as Rofecoxib, Etoricoxib, and 3-(4-methylsulfonylphenyl)-4-phenyl-5-trifluoromethyl isoxazole in high yield. The chemical and radiochemical purities obtained for the 11C-labeled COX-2 inhibitors are >99% with a specific activity >1000 Ci/mmol.

2,3'-BIPYRIDINES DERIVATIVES AS SELECTIVE COX-2 INHIBITORS

The present invention relates to 2,3'-bipyridines of formula (I). Processes for their preparation, pharmaceutical compositions containing them, and their medical uses.

NEW HETEROCYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN MEDICINE

The present invention describes novel compounds having antiinflammatory activity, process for their preparation and pharmaceutical composition containing them.

Annulation of ketones with vinamidinium hexafluorophosphate salts: an efficient preparation of trisubstituted pyridines.

alpha-Aryl ketones react with vinamidinium hexafluorophosphate salts to give access to the corresponding 3-arylpyridines. The annulation reactions proceed in good to excellent yields with vinamidinium salts containing electron-withdrawing groups at the beta-position (R(2)). The reaction was applied to the preparation of the COX-2 specific inhibitor 5-chloro-3-(4-methylsulfonyl)phenyl-2-(2-methyl-5-pyridinyl)pyridine (1), as well as a series of analogues.