2924-80-3

Upstream product

• 122-51-0 orthoformic acid triethyl ester 
• 372-31-6 ethyl 4,4,4-trifluoroacetoacetate 
• 57-13-6 urea 
• 571-55-1 ethyl 2-(ethoxymethylidene)-4,4,4-trifluoro-3-oxobutanoate 

Downstream Products

• 187035-79-6 ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate 
• 149771-09-5 ethyl 2-amino-4-(trifluoromethyl)pyrimidine-5-carboxylate 
• 154934-97-1 ethyl 2-hydroxy-4-trifluoromethylpyrimidine-5-carboxylate 

Relevant academic research and scientific papers

Synthesis of pyrimidine derivatives based on ethyl 2-ethoxymethylidene-3- polyfluoroalkyl-3-oxopropionates: And urea

Ethyl 2-ethoxymethylidene-3-polyfluoroalkyl-3-oxopropionates under mild conditions undergo regioselective condensation with urea at the ethoxymethylidene substituent giving rise to ethyl 3-polyfluoroalkyl-3-oxo-2- (ureidomethylidene)propionates. Under more drastic conditions, the latter cyclize at the fluoroacyl fragment to form ethyl 4-polyfluoroalkyl-4-hydroxy-2- oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates.

Structure-activity relationship studies of ethyl 2-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-4-(trifluoromethyl)pyrimidine- 5-carboxylate: An inhibitor of AP-1 and NF-κB mediated gene expression

Several analogues of ethyl 2-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-4-(trifluoromethyl)pyrimidine- 5-carboxylate (1) were synthesized and tested as inhibitors of AP-1 and NF-κB mediated transcriptional activation in Jurkat T cells. From our SAR work, ethyl 2-[(3-methyl-2,5-dioxo(3-pyrrolinyl))-N-methylamino]-4-(trifluoromethyl)- pyrimidine-5-carboxylate was identified as a novel and potent inhibitor.