2925-57-7

Usage

Physical State

Colorless liquid

Uses

a. Solvent in the chemical industry
b. Intermediate in the synthesis of pharmaceuticals and agrochemicals

Chemical Properties

a. Strong halogen and fluorine bond
b. Highly resistant to chemical reactions

Boiling Point

Relatively low, making it a volatile organic compound

Safety Precautions

Handle and store with extreme caution due to its chemical properties

InChI:InChI=1/C9H5ClF6/c10-7(9(14,15)16)5-2-1-3-6(4-5)8(11,12)13/h1-4,7H

Upstream product

• 384-65-6 1-chloro-2,2,2-trifluoroethylbenzene 
• 128408-37-7 C₉H₅F₆⁽¹⁺⁾ 
• 402-26-6 3-(trifluoromethyl)phenylmagnesium bromide 
• 721-37-9 2,2,2-trifluoro-3'-(trifluoromethyl)acetophenone 
• 50562-22-6 1,1,1-Trifluor-2-(m-trifluormethylphenyl)ethan 
• 721-36-8 α-trifluoromethyl-m-trifluoromethylbenzyl alcohol 

Downstream Products

• 50562-22-6 1,1,1-Trifluor-2-(m-trifluormethylphenyl)ethan 

Relevant academic research and scientific papers

Stille cross-coupling of secondary and tertiary α-(trifluoromethyl)-benzyl chlorides with allylstannanes

A Stille cross-coupling reaction was developed that delivers for the first time trifluoromethyl-substituted homoallyl compounds from α-(trifluoromethyl)benzyl chlorides and allylstannanes. This reaction proceeds even with low catalyst loadings (1 mol%) vi

An efficient dehyrohalogenation method for the synthesis of α,β,β-trifluorostyrenes, α-chloro-β,β- difluorostyrenes and E-1-arylperfluoroalkenes

Dehydrofluorination of 1-aryl-1,2,2,2-tetrafluoroethanes (ArCHFCF 3) and 1-aryl-1-chloro-2,2,2-trifluoroethane (ArCHClCF3) using lithiumhexamethyldisilazide (LHMDS) in tetrahydrofuran (THF) at room temperature produced 1,2,2-trifluorostyrene and 1-chloro-2,2-difluorostyrene, respectively, in very good isolated yields. Dehydrofluorination of 1,2,2,3,3,3-hexafluoro-1-phenyl-propane (PhCHFCF2CF3) and 1,2,2,3,3,4,4,4-octafluoro-1-phenyl-butane (PhCHFCF2CF 2CF3) using LHMDS produced the corresponding substituted olefins (1-phenyl-1,2,3,3,3-pentafluoroprop-1-ene and 1-phenyl-1,2,3,3,4,4,4- pentafluorobut-1-ene) in good yield and high E-selectivity. Dehydrofluorination of 1-chloro-1-phenyl-2,2,3,3,3-pentafluoropropane (PhCHClCF2CF 3) and 1-chloro-1-phenyl-2,2,3,3,4,4,4-heptafluorobutane (PhCHClCF2CF2CF3) produced a mixture of the corresponding E and Z olefins (PhCClCFCF3 and PhCClCFCF 2CF3) in good yield.

Gas phase substituent effects. Stabilities of 1-aryl-2,2,2-trifluoroethyl cations

Gas-phase stabilities of 1-aryl-2,2,2-trifluoroethyl cations were determined based on chloride-transfer equilibria. The substituent effect was analyzed based on the LArSR Eq., giving a remarkably high r of 1.53 and a ρ of -14.6.

MECHANISMS OF FREE-RADICAL REACTIONS. XIII. MECHANISM AND SELECTIVITY OF THE FREE-RADICAL HALOGENATION OF ALKYL AROMATIC HYDROCARBONS WITH FLUOROALKYL SUBSTITUENTS

The free-radical chlorination and bromination of 1-fluoro-2-arylethanes and 1,1,1-trifluoro-2-arylethanes was studied by the method of competing reactions.In all cases a good correalation between log krel and the Brown ?+ constants was observed.The variation of the selectivity in the transition from one reaction series to the other indicates that two independent factors which determine the reactivity (the change in the dissociation energy of the C-H bond and the polar effect of the substituents) have a simultaneous effect.